• SATHEESH NAIK K Department of Anatomy, Bharath University, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
  • GURUSHANTHAIAH M Department of Anatomy, Basaveshwara Medical College, Chitradurga, Karnataka, India.
  • NAGESH RAJU G Department of Pharmacology, Basaveshwara Medical College, Chitradurga, Karnataka, India.
  • LOKANADHAM S Department of Anatomy, Santhiram Medical College and Hospital, Nandyal, Andhra Pradesh, India.
  • SESHADRI REDDY V Department of Biochemistry, Maheshwara Medical College and Hospital Medak, Telangana, India.


Objective: The objective is to study the antihyperlipidemic activity of Eclipta alba in hyperlipidemic albino rats and the use of herbal plants and their parts such as seeds, berries, leaves, roots, barks, or flowers for the development of drugs for therapeutic purposes which have an effective role in recent years.

Methods: A total of 30 adult albino rats of Wistar strain weighing 165–215 g were utilized. Animals were treated with high fat diet for 8 weeks followed by post-treatment of E. alba for 1 week, 2 weeks, and 3 weeks, respectively. After 12 h of fasting on the last day of experiment, serum blood samples were collected in EDTA vials and processed for biochemical analysis.

Results: A significant decrease in levels of total cholesterol and triglycerides was noted on animals treated with E. alba compared to high fat diet animals. Treatment of hypercholesterolemic rats with E. alba showed a marked decrease of serum low-density lipoprotein (LDL) and very LDL-cholesterol concentrations compared to the hypercholesterolemic rats. High fat diet feeding worsened the levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase enzymes, whereas the same markers were significantly improved by supplementation with E. alba compared to normal group.

Conclusion: E. alba acts as antihyperlipidemic agent in hyperlipidemic conditions and helps for better health.

Keywords: Serum, High fat diet, Eclipta alba.

Author Biography

SATHEESH NAIK K, Department of Anatomy, Bharath University, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.



1. Maruthappan V, Shree KS. Effects of Phyllanthus reticulatus on lipid profile and oxidative stress in hypercholesterolemic albino rats. Indian J Pharmacol 2010;42:388-91.
2. Bhathena J, Kulamarva A, Martoni C, Urbanska AM, Malhotra M, Paul A, et al. Diet-induced metabolic hamster model of nonalcoholic fatty liver disease. Diabetes Metab Syndr Obes 2011;4:195-203.
3. Ansarullah A, Jadeja RN, Thounaojam MC, Patel V, Devkar RV, Ramachandran AV. Antihyperlipidemic potential of a polyherbal preparation on triton WR1339 (tyloxapol) induced hyperlipidemia: A comparison with lovastatin. Int J Green Pharm 2009;3:119-24.
4. Ghule BV, Ghante MH, Saoji AN, Yeole PG. Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (Mol.) fruit extracts. Indian J Exp Biol 2006;44:905-9.
5. Wagner H, Geyer B, Kiso Y, Hikino H, Rao GS. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea. Planta Med 1986;5:370-4.
6. Singh A, Duggal S, Suttee A, Singh J, Katekhaye S. Eclpita alba Linn.-ancient remedy with therapeutic potential. Int J Phytopharmacol 2010;1:57-63.
7. Singh P. Naturally occurring thiophene derivatives from Eclipta species. Bioact Mol 1988;7:179-86.
8. Bhattacharya SK, Jha TK, Sundar S, Thakur CP, Engel J, Sindermann H, et al. Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India. Clin Infect Dis 2004;38:217-21.
9. Mani DN, Bawankule UN, Saroj BK. Hyperlipidemic model: Studying lipid profile in small experimental animal. Int J Pharm Pharm Sci 2012;2:337-40.
10. Jahan R, Al-Nahain A, Majumder S, Rahmatullah M. Review-ethnopharmacological significance of Eclipta alba (L.) Hassk. (Asteraceae). Int Sch Res Notices 2014;2014:1-22.
11. Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol 1993;40:155-61.
12. Samudram P, Hari R, Vasuki R, Geetha A, Sathiyamoorthi P. Hepatoprotective activity of bi-herbal ethanolic extract on CCl4 induced hepatic damage in rats. Asian J Biochem Res 2008;2:61-5.
13. Dhandapani R. Hypolipidemic activity of Eclipta prostrata (L.) L. Leaf extract in atherogenic diet induced hyperlipidemic rats. Indian J Exp Biol 2007;45:617-9.
14. Lal VK, Kumar A, Kumar P, Yadav KS. Screening of leaves and roots of Eclipta alba for hepatoprotective activity. Arch Appl Sci Res 2010;2:86-94.
15. Kim DI, Lee SH, Choi JH, Lillehoj HS, Yu MH, Lee GS, et al. The butanol fraction of Eclipta prostrata (Linn) effectively reduces serum lipid levels and improves antioxidant activities in CD rats. Nutr Res 2008;28:550-4.
16. Ananthi J, Prakasam A, Pugalendi KV. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med 2003;76:97-102.
17. Hemalatha S, Ayyappan T, Shanmugan S, Nagavalli D, Kirubha TS. Evaluation of antidiabetic and diuretic activity of polyherbal formulation. Indian J Tradit Knowledge 2006;5:468-70.
5 Views | 23 Downloads
How to Cite
NAIK K, S., G. M, N. RAJU G, L. S, and S. REDDY V. “ANTIHYPERLIPIDEMIC ACTIVITY OF ECLIPTA ALBA IN HIGH FAT DIET-INDUCED HYPERLIPIDEMIC ALBINO RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 230-2, doi:10.22159/ajpcr.2019.v12i2.29491.
Original Article(s)