DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE

  • JAMEER A TAMBOLI Department of Pharmaceutics, Rajarambapu College of Pharmacy, Sangli, Maharashtra, India.
  • SHRINIVAS K MOHITE Department of Pharmaceutics, Rajarambapu College of Pharmacy, Sangli, Maharashtra, India.

Abstract

Objective: The objective of the present study was to develop solid self-microemulsifying drug delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate.


Methods: Three batches of liquid SMEDDS were prepared using oleic acid, Tween 80, and polyethylene glycol 200 as oil, surfactant, and cosurfactant, respectively. Microemulsion region was recognized by constructing a pseudoternary phase diagram containing a different proportion of oil, surfactant, and cosurfactant. Prepared liquid SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size, zeta potential, and viscosity. Liquid SMEDDS was then converted to S-SMEDDS by adsorption technique using Neusilin US2 as a solid carrier. Prepared S-SMEDDS was evaluated for different micromeritic properties, drug content, reconstitution properties, in vitro dissolution study, Fourier transform infrared, and scanning electron microscopy.


Results: The results showed that all batches of liquid SMEDDS were found to be thermodynamically stable. Reconstitution properties of S-SMEDDS showed spontaneous microemulsification with globule size 0.271 μm and −16.18 mV zeta potential. From the results of in vitro dissolution study, it was found that the release of DCN was significantly increased as compared with plain DCN.


Conclusion: The study concluded that dissolution rate of poorly water-soluble drug like DCN can be increased by developing S-SMEDDS formulation.

Keywords: Diacerein, In vitro dissolution study, Neusilin US2, Pseudoternary phase diagram, Self-microemulsifying drug delivery system.

Author Biography

JAMEER A TAMBOLI, Department of Pharmaceutics, Rajarambapu College of Pharmacy, Sangli, Maharashtra, India.

Assistant Professor, Department of Pharmaceutics

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How to Cite
TAMBOLI, J. A., and S. K MOHITE. “DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 315-9, https://innovareacademics.in/journals/index.php/ajpcr/article/view/29500.
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Original Article(s)