• AFSAR SHAIK Faculty of Pharmaceutical Sciences, JNTUA, Ananthapuramu, Andhra Pradesh, India.
  • PRASANNA RAJU YALAVARTHI Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tirupati, Andhra Pradesh, India.
  • CHANDRASEKHAR KOTHAPALLI BONNOTH Department of Chemistry, Oil Technological and Pharmaceutical Research Institute, JNTUA, Ananthapuramu, Andhra Pradesh, India.



0Male antifertility, Decaschistia crotonifolia leaf extract, Testosterone levels, Testes and epididymis


Objective: The objective was to investigate the male antifertility effect of Decaschistia crotonifolia leaf extract on male Wistar rats.

Methods: The animals were divided into three groups of five animals each. The first group (I) served as control and received normal saline, and remaining Groups II and III were treated with plant extract at a dose of 200 and 400 mg/kg p.o., respectively, for 21 days.

Results: Dose-dependent significant decrease in the weight of testes and epididymis was observed. Furthermore, a dose-related reduction in sperm count and motility was observed. A significant decrease in testosterone levels leading to infertility was also observed.

Conclusion: The 70% methanolic leaf extract of D. crotonifolia has produced dose-dependent antifertility effect on male rats.


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How to Cite

SHAIK, A., P. RAJU YALAVARTHI, and C. K. BONNOTH. “ANTIFERTILITY ACTIVITY OF DECASCHISTIA CROTONIFOLIA LEAF EXTRACT ON MALE RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 3, Mar. 2019, pp. 190-2, doi:10.22159/ajpcr.2019.v12i3.29756.



Original Article(s)