ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF JUICE AND ETHANOLIC EXTRACTS OF GARCINIA MANGOSTANA L. LEAVES

  • DINIATIK Departement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia. http://orcid.org/0000-0002-2852-6739
  • ELZA SUNDHANI 2Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia.
  • MUHAMMAD TAUFIQ NUGROHO Departement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia.
  • EUIS NUR HIKMAH Departement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia.
  • RETNO WAHYUNINGRUM Departement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia.
  • SUPARMAN Departement of Organic Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh Purwokerto, Central Java 53182, Indonesia.

Abstract

Objective: Garcinia mangostana is a plant that can be used as a traditional medicine to treat various infectious diseases for the treatment of diarrhea, skin infection, and chronic wounds. The activity as antifungal and antibacterial of juice and ethanolic extract from G. mangostana leaves were investigated.


Methods: Juice and ethanolic extract were concentrated using a rotary evaporator to get concentrated extract with rendemen 2.571 and 5.647% (w/w). Juice and ethanolic extract dilution method were employed to evaluate the antifungal activity against Saccharomyces cerevisiae. Ethanolic extract dilution method was used to assess the antibacterial activity against Bacillus subtilis and Escherichia coli.


Results: The results of this research showed that juice and ethanolic extract were effective against S. cerevisiae, and the minimum inhibitory concentration was 1000, and 500 mg/mL. Antibacterial activity of the G. mangostana leaves ethanolic extract showed that the action was potential with the inhibition zone in B. subtilis and E. coli.


Conclusions: The conclusion of this study is that juice and ethanolic extract of G. mangostana leaves have possible antifungal and antibacterial activity.

Keywords: G. mangostana, antifungal, antibacterial, juice, ethanolic extract

References

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DINIATIK, ELZA SUNDHANI, MUHAMMAD TAUFIQ NUGROHO, EUIS NUR HIKMAH, RETNO WAHYUNINGRUM, and SUPARMAN. “ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF JUICE AND ETHANOLIC EXTRACTS OF GARCINIA MANGOSTANA L. LEAVES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, May 2019, pp. 103-6, https://innovareacademics.in/journals/index.php/ajpcr/article/view/29915.
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