CURCUMIN BENEFITS AS ANTIOXIDANT, ANTIINFLAMATION AND ANTIAPOPTOSIS AMELIORATE PARACETAMOL TOXICITY
Background: Paracetamol poisoning due to the use of paracetamol overdose is the most prevalent case of poisoning. Toxic metabolites from paracetamol cause glutathione depletion and lead to hepatic cell death. Curcumin, a polyphenol substrat in Curcuma longa, has been known to ameliorate the toxic effects of paracetamol. The mechanisms have been known are curcumin as antioxidant, anti-inflammatory, and anti-apoptotic. The curcumin protection mechanism against paracetamol poisoning will be discussed.
Methods: The journalâ€™s search for the protective effects of curcumin on paracetamol toxicity is derived from PubMed database using keyword curcumin and acetaminophen. Research on experimental animals is as the limits of the study subjects of the journal search.
Result: From a search in PubMed database, there are 15 journal titles discussing the effects of curcumin protection against paracetamol toxicity, and 11 journals selected that correspond to the research topic. Of the 11 journals selected, concluded that curcumin was found to prevent worsening of paracetamol toxicity by increasing antioxidant activity and decreasing inflammation and apoptotic.
Conclusion: Curcumin has the potential benefit to be used as a medical therapeutic for the prevention and treatment of paracetamol toxicity.
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