• Tejo Jayadi Department of Anatomical Pathology, Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia,
  • Bowo Widiasmoko Department of Internal Medicine Bethesda Hospital Yogyakarta, Yogyakarta, Indonesia.


Background: Paracetamol poisoning due to the use of paracetamol overdose is the most prevalent case of poisoning. Toxic metabolites from paracetamol cause glutathione depletion and lead to hepatic cell death. Curcumin, a polyphenol substrat in Curcuma longa, has been known to ameliorate the toxic effects of paracetamol. The mechanisms have been known are curcumin as antioxidant, anti-inflammatory, and anti-apoptotic. The curcumin protection mechanism against paracetamol poisoning will be discussed.

Methods: The journal's search for the protective effects of curcumin on paracetamol toxicity is derived from PubMed database using keyword curcumin and acetaminophen. Research on experimental animals is as the limits of the study subjects of the journal search.

Result: From a search in PubMed database, there are 15 journal titles discussing the effects of curcumin protection against paracetamol toxicity, and 11 journals selected that correspond to the research topic. Of the 11 journals selected, concluded that curcumin was found to prevent worsening of paracetamol toxicity by increasing antioxidant activity and decreasing inflammation and apoptotic.

Conclusion: Curcumin has the potential benefit to be used as a medical therapeutic for the prevention and treatment of paracetamol toxicity.

Keywords: Curcumin, Paracetamol, Antioxidants, Anti-inflammatory, Anti-apoptotic.


1. Granados-Castro LF, Rodríguez-Rangel DS, Fernández-Rojas B, León-Contreras JC, Hernández-Pando R, Medina-Campos ON, et al. Curcumin prevents paracetamol-induced liver mitochondrial alterations. J Pharm Pharmacol 2016;68:245-56.
2. Somanawat K, Thong-Ngam D, Klaikeaw N. Curcumin attenuated paracetamol overdose induced hepatitis. World J Gastroenterol 2013;19:1962-7.
3. Li G, Chen JB, Wang C, Xu Z, Nie H, Qin XY, et al. Curcumin protects against acetaminophen-induced apoptosis in hepatic injury. World J Gastroenterol 2013;19:7440-6.
4. Soliman MM, Abdo Nassan M, Ismail TA. Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in wistar rats. BMC Complement Altern Med 2014;14:457.
5. Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD, et al. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res 2012;9:58-71.
6. Kheradpezhouh E, Barritt GJ, Rychkov GY. Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. Redox Biol 2016;7:1 7.
7. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31:1499-506.
8. Heard KJ, Green JL, James LP, Judge BS, Zolot L, Rhyee S, et al. Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. BMC Gastroenterol 2011;11:20.
9. Goldin RD, Ratnayaka ID, Breach CS, Brown IN, Wickramasinghe SN. Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity. J Pathol 1996;179:432-5.
10. Khorsandi L, Orazizadeh M. Protective effect of Curcuma longa extract on acetaminophen induced nephrotoxicity in mice. DARU 2008;16:155-9.
11. Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, Sánchez-Marín L, et al. Acetaminophen-induced liver injury alters the acyl ethanolamine-based anti-inflammatory signaling system in liver. Front Pharmacol 2017;8:705.
12. Mazidi M, Karimi E, Meydani M, Ghayour-Mobarhan M, Ferns GA. Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo. World J Methodol 2016;6:112-7.
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How to Cite
Jayadi, T., and B. Widiasmoko. “CURCUMIN BENEFITS AS ANTIOXIDANT, ANTIINFLAMATION AND ANTIAPOPTOSIS AMELIORATE PARACETAMOL TOXICITY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 15, Oct. 2018, pp. 1-3, doi:10.22159/ajpcr.2018.v11s3.29959.
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