COMPARISON OF ANTIBACTERIAL ACTIVITIES LEAVES EXTRACTS OF CERBERA MANGHAS AND LEAVES EXTRACTS OF AZADIRACHTA INDICA AGAINST KLEBSIELLA PNEUMONIAE


Muhammad Yanis Musdja, Markhamatul Aeni, Ira Djajanegara

Abstract


Objective: This study aims to determine the potential of neem (Azadirachta indica, Juss) leaves and sea mango (Cerbera manghas, Linn.) leaves against Klebsiella pneumonia.

Methods: Hexane and methanol extracts of neem leaves (A. indica, Juss) and hexane and butanol extracts of sea mango leaves (C. manghas, Linn.) were tested antibacterial against K. pneumonia using paper disc and dilution methods, measured the inhibition zone diameter, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC), as a comparison used ampicillin.

Results: The MIC values for the butanol extract and hexane extract of sea mango leaves against K. pneumoniae were 1.124276 and 1.45958 mg/mL, respectively. While the MBC value of both of them had the same value, i.e. 2 mg/ml. The hexane and methanol extracts of neem leaves did not have potentially against the growth of K. pneumonia.

Conclusion: Based on the results of this study have been obtained, that extracts butanol and hexane extract of leaves of sea mango (C. manghas, Linn.) have antibacterial activity strong enough against K. pneumonia, where, extracts butanol leaves of sea mango has antibacterial activity that is more powerful than the extract hexane leaf sea mango, while the methanol extract and hexane extracts of neem (A. indica, Juss) leaves have weak activity against K. pneumonia.


Keywords


Antibacterial, Cerbera manghas, Azadirachta indica, Klebsiella pneumonia.

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About this article

Title

COMPARISON OF ANTIBACTERIAL ACTIVITIES LEAVES EXTRACTS OF CERBERA MANGHAS AND LEAVES EXTRACTS OF AZADIRACHTA INDICA AGAINST KLEBSIELLA PNEUMONIAE

Keywords

Antibacterial, Cerbera manghas, Azadirachta indica, Klebsiella pneumonia.

DOI

10.22159/ajpcr.2018.v11s3.30030

Date

06-10-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Special issue 3 2018 Page: 51-55

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Muhammad Yanis Musdja
Department of Pharmacy, State Islamic University, Syarif Hidayatullah, Jakarta, Indonesia.
Indonesia

Markhamatul Aeni
Department of Pharmacy, State Islamic University, Syarif Hidayatullah, Jakarta, Indonesia.
Indonesia

Ira Djajanegara
Department of Biology, Indonesian Institute of Sciences, PUSPITEK, Serpong, Banten, Indonesia.
Indonesia


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