• DANGAR DK Research scholar, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat.
  • PATEL NJ Departement of Pharmacology, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat.


Objective: Neuracanthus sphaerostachyus has been traditionally used to treat skin diseases, cough, and asthma. Lack of sufficient scientific evidence indicating the utility of this plant in the treatment of inflammation prompted us to investigate the anti-inflammatory activity of the plant in different experimental screening methods.

Methods: In vitro and in vivo anti-inflammatory activity of the methanolic and aqueous extracts of N. sphaerostachyus (MENS and AENS) leaves at doses of 125, 250, and 500 mg/kg was evaluated with albumin denaturation and carrageenan-induced paw edema in rats and acetic acid-induced increased vascular permeability in mice.

Results: Methanolic and aqueous extract significantly inhibited protein denaturation as well as edema induced by carrageenan and vascular permeability in mice dose dependently. Aspirin (0.1 mg/ml), indomethacin (10 mg/kg), and dexamethasone (5 mg/kg) were used as a standard control.

Conclusion: It is concluded that MENS and AENS leaves exhibited significant anti-inflammatory activity.

Keywords: Neuracanthus sphaerostachyus, Inflammation, Paw edema, Albumin denaturation, Vascular permeability.

Author Biography

DANGAR DK, Research scholar, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat.

Associate Professor & Head,

Department of Pharmacology,

Shree S. K. Patel College of Pharmaceutical Education &

Research, Ganpat University


1. Gambhire MN, Wankhede SS, Juvekar AR. Antiinflammatory activity of aqueous extract of Barleriacristata. J Young Pharm 2009;1:220-4.
2. Salah A, Honda MG, Miki W. Herb drugs and herbalists in the Middle East institute for the study of languages and cultures of Asia and Africa. Stud Cultu Islamicae 1979;8:1-7.
3. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. New York: Springer Publication; 2007. p. 372-3.
4. Punjani BL, Kumar V. Traditional medicinal plant remedies to treat cough and asthmatic disorders in the Aravalli ranges in North Gujarat, India. J Nat Remedies 2002;2:173-8.
5. Daniel M, Sabnis SD. Chemosystematics of some Indian members of the Acanthaceae. Indian Acad Sci (Plant Sci) 1987;97:315-32.
6. Singh RM. Indian Pharmacopoeia. 2nd ed. New Delhi: Government of India; 1966. p. 33-4.
7. Committee for the Purpose of Control and Supervision on Experiments on Animals. CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol 2003;35:257-74.
8. Available from: pdf 425 adopted 17/12/2001.
9. Islam M, Ibrahim M, Qamrul Ahsan M, Uddin Chowdhury MM, Aslam Hossain M, Rashid MA. Phytochemical and pharmacological investigations of Uraria lagopodies DC and Urena lobata L. Dhaka Univ J Pharm Sci 2012;11:65-9.
10. Pandey K, Sharma P, Dudhe R. Antioxidant and anti-inflammatory activity of ethanolic extract of Parthenium hysterophorus Linn. Asian J Pharm Clin Res 2012;5:28-31.
11. Neha PV, Suganthi V, Gowri S. Evaluation of anti-inflammatory activity in ethanolic extract of Coriandrum sativum L. using carrageenan induced paw oedema in albino rats. Pharm Chem 2013;5:139-43.
12. Santos EN, Lima JC, Noldin VF, Cechinel-Filho V, Rao VS, Lima EF, et al. Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models. An Acad Bras Cienc 2011;83:557-66.
13. Dangar DK, Shenoy AM, Moses SR. Anti-allergic activity of Naravelia zeylanica leaves. Inventi Rapid Ethnopharmacol 2013;2:1-3.
14. Sakat S, Juvekar AR, Gambhire MN. Invitroantioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata linn. Int J Pharm Pharm Sci 2010;2:146-51.
15. Dimo T, Fotio AL, Nguelefack TB, Kamtchouing P. Anti-inflammatory activity of leaf extracts of Kalancho ecrenata andr. Indian J Pharmacol 2006;38:115-9.
16. Emmanuel AM, Thiombianol NO, Martin K, Marius L. Anti-inflammatory, analgesic and antioxidant activities of hydro-acetonic extract from Wissadula amplissima var. Rostrata (shum. and thonn.) R. E. Fries. Int J Pharm Pharm Sci 2018;10:113-7.
17. Urmila U, Supada R. In vitro antioxidant and in vivo anti-inflammatory activity of the aerial part of Blumea eriantha DC. Int J Pharm Pharm Sci 2018;10:75-9.
184 Views | 227 Downloads
How to Cite
DK, D., and P. NJ. “ANTI-INFLAMMATORY ACTIVITY OF NEURACANTHUS SPHAEROSTACHYUS DALZ. LEAVES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 3, Mar. 2019, pp. 227-9, doi:10.22159/ajpcr.2019.v12i3.30059.
Original Article(s)