THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS

  • DHARMA LINDARTO Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
  • YETTY MACHRINA Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
  • SANTI SYAFRIL Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
  • AWALUDDIN SARAGIH Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Abstract

Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs).


Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period.


Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05).


Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

Keywords: Type 2 diabetes mellitus, Puguntano, Adiponectin receptor.

Author Biography

DHARMA LINDARTO, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

Department of Internal Medicine, Division of endocrine-metabolic

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LINDARTO, D., Y. MACHRINA, S. SYAFRIL, and A. SARAGIH. “THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 2, Jan. 2019, pp. 551-3, doi:10.22159/ajpcr.2019.v12i2.30456.
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