• RAMACHANDRAN S Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • SRI RAMYA M Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • LIZA U Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • LAKSHMI PRASANNA PS Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • SARISHMA K Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.


Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats.

Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed.

Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control.

Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.

Keywords: Indian shrimp, Aluminum chloride, Alzheimer’s, Rivastigmine.


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How to Cite
S, R., S. R. M, L. U, L. P. PS, and S. K. “EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 3, Feb. 2019, pp. 377-82, https://innovareacademics.in/journals/index.php/ajpcr/article/view/30720.
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