EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS

  • RAMACHANDRAN S Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • SRI RAMYA M Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • LIZA U Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • LAKSHMI PRASANNA PS Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
  • SARISHMA K Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.

Abstract

Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats.


Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed.


Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control.


Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.

Keywords: Indian shrimp, Aluminum chloride, Alzheimer’s, Rivastigmine.

References

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Global prevalence of dementia: A Delphi consensus study. Lancet 2005;366:2112-7.
2. Kiranjit K, Rajneet K, Manjinder K. Recent advances in Alzheimers disease: Cause and treatment. Int J Pharm Sci 2016;8:8-15.
3. Manohar BS, Suryakanta S, Renuka K. Neuroprotective activity of fractional flower extracts of Mirabilis jalapa against aluminium hydrochloride induced neurotoxicity in male wistar rats. Int J Pharm Sci 2017;9:216-21.
4. Ramachandran S, Dhanaraju MD, Sanjay AS. Alzheimer ’s disease and potential therapeutic targets. Int J Compr Pharm 2013;4:1-7.
5. Cam JA, Bu G. Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Mol Neurodegener 2006;1:8.
6. Reed TT, Pierce WM, Markesbery WR, Butterfield DA. Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Brain Res 2009;1274:66-76.
7. Wang B, Xing W, Zhao Y, Deng X. Effects of chronic aluminum exposure on memory through multiple signal transduction pathways. Environ Toxicol Pharmacol 2010;29:308-13.
8. Justin Thenmozhi A, Raja TR, Janakiraman U, Manivasagam T. Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer’s disease in Wistar rats. Neurochem Res 2015;40:767-76.
9. Morris MC, Brockman J, Schneider JA, Wang Y, Bennett DA, Tangney CC, et al. Association of seafood consumption, brain mercury level, and APOE ?4 status with brain neuropathology in older adults. JAMA 2016;315:489-97.
10. Junio D, Nadine L, Piotr B. Shrimp protein hydrolysate modulates the timing of proinflammatory macrophages in bupivacaine-injured skeletal muscles in rats. BioMed Res Int 2016;2016:1-13.
11. Ramachandran S, Sanjay AS, Dhanaraju MD. Antiamnesic effect of Piracetam potentiated with Emblica officinalis and Curcuma longa in aluminium induced neurotoxicity of Alzheimer’s disease. Int J Adv Res 2013;1:185-96.
12. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984;11:47-60.
13. Srikumar BN, Raju TR, Shankaranarayana Rao BS. The involvement of cholinergic and noradrenergic systems in behavioral recovery following oxotremorine treatment to chronically stressed rats. Neuroscience 2006;143:679-88.
14. Kulkarni S. Experiment No. 4.4 to study CNS depressant property of chlorpromazine on locomotor activity of mice using actophotometer. In: Handbook of Experimental Pharmacology. New Delhi: Vallabh Prakashan; 1999. p. 117-9.
15. Gupta A, Dhir A, Kumar A, Kulkarni SK. Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats. Pharmacol Biochem Behav 2009;94:219-26.
16. Ellman GL, Courtney KD, Andres V Jr., Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88-95.
17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
18. Ravindranath V, Shivakumar BR, Anandatheerthavarada HK. Low glutathione levels in brain regions of aged rats. Neurosci Lett 1989;101:187-90.
19. Mavelli I, Rigo A, Federico R, Ciriolo MR, Rotilio G. Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain. Biochem J 1982;204:535-40.
20. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978;186:189-95.
21. Erazi H, Sansar W, Ahboucha S, Gamrani H. Aluminum affects glial system and behavior of rats. C R Biol 2010;333:23-7.
22. Buckner RL, Kelley WM, Petersen SE. Frontal cortex contributes to human memory formation. Nat Neurosci 1999;2:311-4.
23. Abdel-Aal RA, Assi AA, Kostandy BB. Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol 2011;659:169-76.
24. Khan KA, Kumar N, Nayak PG, Nampoothiri M, Shenoy RR, Krishnadas N, et al. Impact of caffeic acid on aluminium chloride-induced dementia in rats. J Pharm Pharmacol 2013;65:1745-52.
25. Kröger E, Laforce R Jr. Fish consumption, brain mercury, and neuropathology in patients with Alzheimer disease and dementia. JAMA 2016;315:465-6.
26. Lekha G, Bhagya PK, Rao S, Arockiasamy I, Mohan K. Cognitive enhancement and neuroprotective effect of Celastrus paniculatus wild seed oil (Jyothismatioil) on male Wistar rats. J Pharm Sci Technol 2011;2:130-8.
27. Germano C, Kinsella GJ. Working memory and learning in early Alzheimer’s disease. Neuropsychol Rev 2005;15:1-10.
28. Takeuchi H, Jin S, Suzuki H, Doi Y, Liang J, Kawanokuchi J, et al. Blockade of microglial glutamate release protects against ischemic brain injury. Exp Neurol 2008;214:144-6.
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S, R., S. R. M, L. U, L. P. PS, and S. K. “EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 3, Feb. 2019, pp. 377-82, https://innovareacademics.in/journals/index.php/ajpcr/article/view/30720.
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