PROTECTIVE EFFECT OF MIRABILIS JALAPA LEAVES ON ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY
Objectives: The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa Linn leaves on anti-tubercular drugs induced hepatotoxicity. Methods: Anti-tubercular drugs were used to induce hepatotoxicity. Ethanolic extract of leaves of Mirabilis Jalapa Linn (250 & 500 mg/kg p.o.) was administered with one hour prior administration of anti-tubercular drugs once daily for 35 days. Silymarin was used as standard drug (100 mg/kg p.o.). Results: Liver biomarkers such as SGOT, SGPT, ALP, TB, total cholesterol were elevated and total HDL were reduced on anti-tubercular drugs administration. Pretreatment of ethanolic extract of leaves of Mirabilis Jalapa Linn 250 mg/kg and 500 mg/kg with anti-tubercular drugs were significantly reduced liver biomarker enzymes. Antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed and increased TBARs levels in anti-tubercular drugs administration but restored these antioxidant levels in pretreatment of ethanolic extract of Mirabilis Jalapa Linn leaves at a dose of 250 mg/kg and 500 mg/kg. Conclusion: The result of the present study was indicated that Mirabilis Jalapa Linn showed hepatoprotective effect on hepatotoxicity induced by anti-tubercular drugs.
Key Words: Hepatoprotective activity, Anti-tubercular drugs, Liver biomarkers, Mirabilis Jalapa, Antioxidant parameters.
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