Boswellia serrata (Burseraceae) is the most ancient and respected herbs in Ayurveda. In Unani system of medicine, oleo-gum resin of Boswellia serrata named Kundur played a prime ingredient role in modern quality perfumes. The gum is used as a remedy for treatment of illness especially skin diseases and rheumatism in Indian system of medicine (Sidha, Ayurvedic and Unani) for last diverse centuries. Salai guggul is one of the accepted drugs for various complaints such as dyspepsia, dysentery, lung diseases, urinary disorder, haemorrhoids and corneal ulcer in Unani system of medicine for the last several decades.

The present article is aimed to provide an overview on various pharmacological activities of Boswellia serrata. The resin fraction of salai guggal is rich in boswellic acids and its essential oils that are composed of a mixture of mono, di and sesquiterpenes while gum fraction chiefly contains pentose and hexose sugars. The oleo-gum resin is quite popular among the practitioners of traditional system and possesses wide range of useful biological properties such as antiasthmatic, anticancer, antifungal, anticomplementary, antihyperlipidemic, antiinflammatory, antiarthritic, antirheumatic, antidiarrheal, antimicrobial, antifungal and analgesic.

An exhaustive review of literature was performed using various databases on science direct, scopus, pubmed, google scholar and free patents online.

This review is a sincere attempt to discuss and present the current status of pharmacological profile of Boswellia serrata.

Keywords: Boswellia serrata, Inflammation, Boswellic acids, Leukotriene synthesis, Pharmacology

Author Biography

SUNEELA DHANESHWAR, Director Amity Institute of Pharmacy, Dy Dean Research Amity University Uttar Pradesh Lucknow UP

Professor of Pharmaceutical Chemistry

Director Amity Institute of Pharmacy,                                   Dy Dean Research Amity University Uttar Pradesh

Lucknow Campus Lucknow


1. Siddiqui MZ, Boswellia serrata, a potential anti-inflammatory agent: an overview, Indian Journal of Pharm Sci, 2011; 73(3):255-61.

2. Shah BA, Qazi GN, Taneja SC, Boswellic acids: a group of medicinally important compounds, Nat Product Rep, 2009; 26(1):72-8.

3. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Frankincense: from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious disease, J Trad Comp Med, 2013; 3(4): 221-6.

4. Zhang Y, Ning Z, Lu C, Zhao S, Wang J, Liu B, Xu X, Liu Y, Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties, Chem Cent J, 2013; 7:153.

5. Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A, Prospects of boswellic acids as potential pharmaceutics, Planta Med, 2015; 81: 259-71.

6. Ammon H P T, Modulation of the immune system by Boswellia serrata extracts and boswellic acids, Phytomedicine, 2010; 17: 862-867.

7. Herrmann A, Konig S, Lechtenberg M, Sehlbach M, Vakhrushev SY, Peter-Katalinic J, Hensel A, Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein, Glycobiology Advance Access published July, 2012; 6: 1424–1439.

8. Ammon HPT, Boswellic Acid in Chronic Inflammatory Disease. Pharmacologi Univesitat Tubingen. 2006. http://www.indianboswellia. com/pdf/Prof _Ammon _ Research.pdf.Cited on 27 August 2014.

9. Birkner KM, Boswellia, The Pain Herb. Pain and Stress Publications; San Antonio: Texas; 2006.

10. Upaganlawar A, Ghule B, Pharmacological Activities of Boswellia serrata Roxb. - Mini Review, Ethnobotanical Leaflets, 2009; 13: 766-774.

11. Sultana A, Takaoka J, Koga T, Boswellia serrata roxb. A traditional herb with versatile pharmacological activity: a review, IJPSR, 2013; 4(6): 2106-2117.

12. Alam M, Khan H, Samiullah L, Siddique K.M, A review on Phytochemical and Pharmacological studies of Kundur (Boswellia serrata Roxb ex Colebr.) -A Unani drug, Journal of Applied Pharmaceutical Science, 2012; 02 (03): 148-156.

13. Gerbeth K, Meins J, Kirste S, Momm F, Schubert-Zsilavecz M, Abdel-Tawab M, Determination of major boswellic acid in plasma by high-pressure liquid chromatography/mass spectrometry, J Pharm Biomed Anal, 2011; 56(5): 998-1005.

14. Al-Harrasi A, Ali L, Rehman NU, Hussain H, Hussain J, AlRawahi A, et al. Nine triterpenes from Boswellia sacra Fluckiger ¨ and their chemotaxonomic importance. Biochem Syst Ecol, 2013; 51: 113-6.

15. Sterk V, Bu chele B, Simmet T, Simultaneous food intake enhances the bioavailability of frankincensebased phytopharmaceuticals, Zeitschrift fur Phytotherapie, 2005;26:174-80.

16. Sterk V, Bu chele B, Simmet T, Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers, Planta Medica, 2004;70:1155-60.

17. Poeckel D, Werz O, Boswellic acids: Biological actions and molecular targets, Current Medicinal Chemistry, 2006;13: 3359-69.

18. Wang C, Xia L, Song Z, Li Q, Wang C, Zeng L, Liu Z, Determination of five boswellic acids in Boswellia serrata, Zhongguo Zhong Yao Za Zhi, 2011; 36(10): 1330-3.

19. Moussaieff A, Gross M, Nesher E, Tikhonov T, Yadid G, Pinhasov A, Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals, J Psychopharmacol, 2012; 26(12): 1584-93.

20. Paul M, Jaunch J, Efficient preparation of incensole and incensole acetate, and quantification of these bioactive diterpenes in Boswellia papyrifera by a RP-DAD-HPLC method, Nat Prod Commun, 2012; 7(3): 283-8.

21. Bhushan S, Malik F, Kumar A, Isher HK, Kaur IP, Taneja SC, Qazi GN, Singh J, Activation of p53/p21/PUMA alliance disruption of PI-3/ Akt in multimodal targeting of apoptotic signalling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata, Mol Carcinog, 2009; 48(12): 1093-108.

22. Schmidt TJ, Kaiser M, Brun R, Complete structural assignment of serratol, a cemembrane-type diterpene from Boswellia serrata and evaluation of its antiprotozoal activity, Planta Med, 2011; 77(8): 849-50.

23. Morikawa T, Oominami H, Matsuda H, Yoshikawa M, New terpenoids, olibanumols D–G, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii, J Nat Med, 2011; 65: 129-34.

24. Song Z, Xia L, Wei Z, Cao Y, Zhang L, Liu Z, Determination of alpha-pinene and octyl acetate contents in Boswellia serrata, Zhongguo Zhong Yao Za Zhi, 2012; 37(10): 1431-3.

25. Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HPT, Safayhi H, Acetyl-1 1-keto-b-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity, Br J Pharmacol,1996; 117: 615-8.

26. Al-Harrasi A, Al-Saidi S, Phytochemical analysis of the essential oil from botanically certified oleogum resin of Boswellia sacra (Omani luban), Molecules, 2008; 13(9): 2181-9.

27. Kreck C, Saller R, Indidcher Weihrauch und seine Zubereitungen einschliesslich H15 als traditionelles und modernes Therpeutikun. Internist Prax, 1998, 38: 857-72.

28. Buchele B, Zugmaier W, Simmet th, Analysis of pentacyclic triterpenic acids from frankincense gum resins and related phytopharmaceuticals by high-performance liquid chromatography. Identification of leupeolic acid , a novel pentacyclic triterpenes, J Chromatography B, 2013, 791: 21-23.

29. Sharma S, Thawani V, Hingorani L, Shrivastava M, Bhate VR, Khiyani R, Pharmacokinetic study of 11-keto b-boswellic acid, Phytomedicine, 2004; 11(2–3): 255-60.

30. Sterk V, Bu chele B, Simmet T, Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers, Planta Medica, 2004;70:1155-60.

31. Bairwa K, Jachak SM, Nanoparticle formulation of 11-keto-β-boswellic acid (KBA):anti-inflammatory activity and in vivo pharmacokinetics, Pharm Biol, 2016; 54(12): 2909-2916.

32. Hüsch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M, Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract, Fitoterapia, 2013; 84: 89–98.

33. Sengupta.K, Jyaprakash N.Kolla. Alluri V. Krishnaraju. Yalamanchili N. Chirravuri V.Rao. Golakoti T. Raychaudhuri S .Siba P. Raychaudhuri, Cellular and molecular mechanism of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract, mol cell biochem, 2011; 354: 189-197.

34. Fartyal S, Jha SK, Karchuli MS, Gupta R, Vajpayee A, Formulation and Evaluation of Floating Microspheres of Boswellic acid, International Journal of PharmTech Research, 2011; 3(1): 76-81.
35. Sharma A, Gupta NK, Dixit VK, Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid, Drug Delivery, 2010; 17(8): 587-595.

36. Goel A, Ahmad FJ, Singh RM, Singh GN, 3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity, J Pharm Pharmacol, 2010; 62(2):273-8.

37. Poeckel D, Werz O, Boswellic acids: biological actions and molecular targets, Curr Med Chem, 2006; 13(28): 3359-69.
38. Ammon HP, Mack T, Singh GB, Safayhi H, Inhibition of leukotriene B4 formation in rat peritoneal neutrophiles by an ethanolic extract of gum resin exudates of Boswellia serrata, Planta Med, 1991; 57: 203-7.

39. Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP, Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase, J Pharmacol Exp Ther, 1992; 261(3): 1143 -6.

40. Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Sexena AK, Singh J, Taneja SC, Acyl derivatives of boswellic acids as inhibitors of NF-kB and STATs, Bioorg Med Chem Lett, 2012; 22: 431-5.

41. Skarke C, Kuczka K, Tausch L, Werz O, Rossmanith T, Barrett JS, Harder S, Holtmeier W, Schwarz JA, Increased bioavailability of 11-keto-betaboswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures, J Clin Pharmacol, 2012; 52: 1592-600.

42. Husch J, Gerbeth K, Fricker G, Setzer C, Zirkel J, Rebmann H, Schubert-Zsilavecz M, Abdel-Tawab M, Effect of phospholipid-based formulation of Boswellic serrata extract on the solubility, permeability and absorption of the individual boswellic acid constituents present, J Nat Prod, 2012; 75(10): 1675-82.

43. Husch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schbert-Zsilavecz M, Abdel-Tawab M, Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome) of Boswellia extract, Fitoterapia, 2013; 84: 89-98.

44. Gerbeth K, Husch J, Fricker G, Werz O, Schubert-Zsilavecz M, Abdel-Tawab M, In vitro metabolism, permeation and brain availability of six major boswellic acids from Boswellia serrata gum resins, Fitoterapia, 2013; 84: 99-106.

45. Kruger P, Daneshfar R, Eckert GP, Klein J, Volmer DA, Bahr U, Muller WE, Karas M, Schubert-Zsilavecz M, Abdel-Tawab M, Metabolism of boswellic acids in vitro and in vivo, Drug Metab Dispos, 2008; 36(6): 1135-42.

46. Takada Y, Ichikawa H, Badmaev V, Aggarwal BB, Acetyl-11- keto-beta-boswellic acid potentiates apoptosis, inhibits invasion and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression, J Immunol, 2006; 176(5): 3127-40.

47. Safayhi H, Roll B, Sailer ER, Ammon HP, Inhibition by boswellic acids of human leukocyte elastase, J Pharmacol Exp Ther, 1997; 281(1): 460-3.

48. Knaus U, Wagner H, Effect of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system, Phytomedicine, 1990; 3: 77-80.

49. Huang MT, Bacdmaev V, Ding V, Liu Y, Xie JG, Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid, Biofactors, 2000; 13(1–4): 225-30.

50. Safayhi, H., Rall B, Sailer ER, Ammon HP, Inhibition by boswellic acids of human leukocyte elastase, Journal of Pharmacology and Experimental Therapeutics, 1997; 460-3.

51. Knaus U, Wagner H, Effect of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system, Phytomedicine, 1990; 3: 77-80.

52. Kapil A, Anti-complementary activity of boswellic acids, Chemistry and Biology of Herbal Medicine, 1997; 175-184.

53. Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK, Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leukocyte migration, Agents Actions, 1988; 161-4.

54. Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP, Boswellic acids: novel, specific, nonredox inhibitors of 5lipoxygenase, J Pharmacol Exp Ther, 1992; 1143-6.

55. Safayhi H, 5-lipoxygenase inhibition by acetyl-11-keto-boswellic acid (AKBA) by a novel mechanism, Phytomedicine, 1996: 71-2.

56. Singh GB, Atal CK, Pharmacology of an extract of salai guggul ex. Boswellia serrata. Indian J Pharmacol , 1984:16-51.

57. Sharma ML, Bani S, Singh GB, Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA) – induced arthritis, Int J Immunopharmacol, 1989; 11(6):647-52.

58. Ammon HP, Mack T, Singh GB, Safayhi H, Inhibition of leukotriene B4 formation in rat peritoneal neutrophiles by an ethanolic extract of gum resin exudates of Boswellia serrata, Planta Med, 1991; 57: 203-7.

59. Kulkarni R, Patki P, Jog V, Gandage S, Patwardhan B, Treatment of osteoarthritis with a herbomineral formulation: A double blind, placebocontrolled, cross-over study, J Ethnopharmacol, 1991;33:91-5.

60. Chopra A, Lavin P, Patwardhan B, Chitre D, Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis, J Rheumatol, 2000;27:1365-72.

61. Gupta OP, Sharma N, Chand D, A sensitive and relevant model for evaluating anti-inflammatory activity – papaya latex-induced rat paw edema, J Pharmacol Toxicol Methods, 1992; 28: 15-9.

62. Gayathri B, Manjula N, Vinaykumar KS, Lakshmi BS, Balakrishnan A, Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFa, IL-1b, NO and MAP kinases, Int Immunopharmacol, 2007; 7(4): 473-82.

63. Khosravi SM, Mahmoodian H, Moghadamnia A, Poorsattar BMA, Chitsazan M, The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial, DARU J Pharm Sci, 2011; 19(4): 288-94.

64. Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B, Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: randomized trial, Int J Immunopathol Pharmacol, 2016; 29(1): 140-6.

65. Al-Harrasi A, Al-Rawahi A, Hussain J, Ali L, Hussain H, Rehman N, Abbas G, Mehjabeen, Al-Harrasi R, First in vitro lipid peroxidation and in vivo antiinflammatory activity of the Omani frankincense of Boswellia sacra Flueck, Int J Phytomed, 2013; 5: 73-7.

66. Mothana RA, Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Sogotraen Boswellia elongata Balf. F and Jatropha unicostata Balf. F. in different experimental models, Food Chem Toxicol, 2011; 49: 2594-9.

67. Sharma A, Bhatia S, Kharya MD, Gajbhiye V, Ganesh N, Namdeo AG, Mahadik K.R, Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata, Int J Phytomed, 2011; 2: 94-9.

68. Menon M. K, Kar A, Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata. Planta, Med, 1971; 333-341.

69. Sharma A, Bhatia S, Kharya M D, Gajbhiye V, Ganesh N, Namdeo A.G, K Mahadik K.R, Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata International Journal of Phytomedicine, 2010; 2: 94-99.

70. Vongtau HO, Abbah J, Ngazal IE, Kunle OF, Chindo BA, Otsapa PB, Gamaniel KS, Antinociceptive and anti-inflammatory activity of methanolic extract of Perinari polyandra stem bark in rats and mice, J of Ethnopharmacol, 2004; 90: 115-121.

71. Bishnoi M, Patil CS, Kumar A, Kulkani SK, Analgesic activity of acetyl-11-keto-b-boswellic acid, a lipooxygenase – enzyme inhibitor, Indian J Pharmacol, 2005; 37(4): 255-6.

72. Al-Harrasi A, Ali L, Hussain J, Rehman NU, Ahmed M, AlRawahi A, Analgesic effects of crude extracts and fractions of Omani frankincense obtained from traditional medicinal plant Boswellia sacra on animal models, Asian Pac J Trop Med, 2014; 7: S485-90.

73. Chaurasia A and Gharia A, Antifungal activity of medicinal plant Boswellia Serrata. Journal of Ultra Chemistry, 2017; 13(4): 88-90.
74. Garg S.C, Antifungal activity of some essential oils, Ind J Pharmacol, 1974; 36: 47-47.

75. Zutsi U, Rao PG and Kaur S, Mechanism of cholesterol lowering effect of Salai guggal ex-Boswellia serrata Roxb, Indian J. Pharmacol, 1986; 18: 182-183.

76. Gerlach U, Sorbitol dehydrogenase In: Bergmeyer, H.U. (ed.), Methods of enzymatic analysis, Third ed. Verlag Chemie, Weinheim, 1983; 112-117.

77. Azadmehra A, Ziaeeb A, Ghaneib L, Huseinic H F, Hajiaghaeed R, Tavakoli-fare B and Kordafsharif G, A randomized clinical trial study: anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic effects of Olibanum Gum in Type 2 diabetic patients, Iranian Journal of Pharmaceutical Research, 2014; 13 (3): 1003-1009.

78. Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP, Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE), Phytomedicine, 2011; 18: 1037-44.

79. Zutshi U, Siddiqui M, Singh G. B, Atal C. K, Mechanism of Action of Salai Guggul as Antilipidmic, Agent Souvenier, 13th Indian Pharmacological Society, Conference. 1980; 1-31.

80. Zutshi U, Rao PG, Kaur Samagat, Singh GB, Atal CK, Mechanism of cholesterol lowering effect of Salai guggal ex- Boswellia serrata, Indian J Pharm, 1980; 12: 59.

81. Liu JJ, Toy WC, Liu S, Cheng A, Lim BK, Subramaniam T, Sum CF, Lim SC, Acetyl-keto-b-boswellic acid induces lipolysis in mature adipocytes, Biochem Biophys Res Commun, 2013; 431(2): 192-6.

82. Ismail1 S M, Aluru S, Sambasivarao KRS and Matcha B, Antimicrobial activity of frankincense of Boswellia serrata. International Journal of Current Microbiology and Applied Sciences, 2014; 3 (10): 1095-1101.

83. Patel N.B, Patel K.C, antibacterial activity of Boswellia serrata roxb. Ex colebr. Ethanomedicinal plant against gram negative UTI pathogens, Reasearch Gate, 2014; 53.

84. Baratta M. T, Dorman H. J. D, Deans S. G, Figueiredo A. C, Barroso J. G. Ruberto G, Antimicrobial and antioxidant properties of some commercial essential oils. Flavour and Fragrance Journal, 1998; 13(4):235-240.

85. Raja AF, Ali F, Khan IA, Shawl AS, Arora DS, Shah BA, Taneja SC. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-b-boswellic acid from Boswellia serrata, BMC Microbiol, 2011; 11: 54.

86. Gupta I., Gupta V, Parihar A., Gupta S., Ludtke R., Safayhi H., Ammon H.P, Effect of Boswellis serrata gum resin in bronchial asthma, Eur. J. Med. Res, 1998; 3: 511-514.

87. Miller A. L. Effects of Boswellia serrata on asthma, Altern, Med. Rev. 2001; 6(1): 20-47.

88. Liu Z, Liu X, Sang L, Liu H, Xu Q, Liu Z. Boswellic acid attenuates asthma phenotypes by downregulation of GATA3 via pSTAT6 inhibition in a murine model of asthma, Int J Clin Exp Pathol, 2015; 8(1): 236-43.

89. Ali EN, Mansour SZ. Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats, Chin Med, 2011; 36.

90. Borrelli F, Capasso F, Capasso R, Ascione V, Aviello G, Longo R, Izzo AA. Effect of Boswellia serrata on intestinal motility in rodants: inhibition of diarrhoea without constipation, Brit J Pharmacol, 2006; 148: 553-60.

91. Shah BA., Qazi GN., Taneja SC. Boswellic acids: a group of medicinally important compounds, Nat. Prod. Rep, 2009; 26: 72-89.
92. Liu JJ, Huang B, Hooi SC, Acetyl-keto-betaboswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells, Br J Pharmacol, 2006; 148: 1099-107. 20.

93. Lu M, Xia L, Hua H, Jing Y, Acetyl-keto-betaboswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells, Cancer Res, 2008; 68: 1180-6 21.

94. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis, Cancer Res, 2009; 69: 5893-900.

95. Hostanska K, Daum G, Saller R, Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro, Anticancer Res, 2002; 22: 2853-62. 23.

96. Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD, Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway, Int J Mol Med, 2002; 10: 501-5. 24.
97. Glaser T, Winter S, Groscurth P, Safayhi H, Sailer ER, Ammon HP, Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. Br J Cancer, 1999; 80: 756-65.

98. Takada Y, Ichikawa H, Badmaev V, Aggarwal BB. Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion and abolishes osteoclastogenesis by suppressing NFkappaB and NFkappaB-regulated gene expression, J Immunol, 2006; 176: 3127-40.
99. Sinha VR, Singh A, Singh S, Bhinge JR. Compression coated systems for colonic delivery of 5-fluorouracil. J. Pharm. Pharmacol, 2007; 59: 359-365.

100. Ahmed HH, Rahman MA, Zahraa F, Shalby A, Lokman MS. Antitumor efficacy of boswellia serrata extract in management of colon cancer induced in experimental animal, Int J Pharm Sci, 2013; 3: 379-389.
101. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB, Liu MI. Acetyl-11-Keto-B-Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis, Cancer Res, 2009; 69: 5893-900.

102. McCarty MF. Targeting multiple signaling pathways as a strategy for managing prostate cancer: Multifocal signal modulation therapy, Integrative Cancer Therapies, 2004; 3: 349-80.
103. Kapil A., Moza N. Anticomplementary activity of boswellic acid an inhibitor of C3-convertase of the classical complement pathway, Int. J. Immunopharmacol, 1992; 14: 1139-1143.

104. Hosseini M, Hadjzadeh MA, Derakhshan M, Havakhah S, Rassouli FB, Rakhshandeh H, Saffarzadeh F. The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze, Arch Pharm Res, 2010; 33(3): 463-8.

105. Mahmoudi A, Hosseini-Sharifabad A, Monsef-Esfahani HR, Yazdinejad AR, Khanavi M, Roghani A, Beyer C, Sharifzadeh M. Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats, J Nat Med, 2011; 65(3–4): 519-25.

106. Prabhakar A, Chandrashekar R, Rao S.N, Evaluation of antidepressant activity of boswellia serrata in swiss albino mice by forced swim test, International Journal of Universal Pharmacy and Biosciences, 2013; 2(3): 417-424.
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How to Cite
PILKHWAL, N., and S. DHANESHWAR. “AN UPDATE ON PHARMACOLOGICAL PROFILE OF BOSWELLIA SERRATA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 5, May 2019, pp. 49-56, doi:10.22159/ajpcr.2019.v12i5.31260.
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