A NOVEL APPROACH FOR DELIVERY OF RISPERIDONE USING EURYALE FEROX BIOPOLYMER FOR TRANSVERMILLION DELIVERY FOR THE MANAGEMENT OF PSYCHOSIS

  • BHAVANA SINGH Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India
  • SATHEESH MADHAV NV Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India.

Abstract

Objective: The purpose of the present study was to formulate and evaluate risperidone loaded bioflexi films for effective treatment of psychosis. For the preparation of bioflexi films, biopolymer was isolated from seeds of Euryale ferox (family Nymphaeaceae) by an economic method. The biopolymer recovered from the concentrate was subjected for various physiochemical properties such as color, solubility, color changing point, and chemical test.


Methods: The bioflexi films were prepared using this biopolymer, dextrose as flexicizer, and sween 80 as permeation enhancer in methanol and water as solvent system.


Results: The formulations were characterized including uniformity of weight, drug content, folding endurance, and thickness. To study the stability of the formulations and in vitro dissolution of the experimental formulations were performed to determine the amount of risperidone present in the patches and scanning electron microscopy of the prepared bioflexi films was taken to see the drug distribution pattern. Drug-excipient interaction studies were carried out using Fourier transform infrared spectroscopic technique. In vitro dissolution studies showed that the drug distribution in the bioflexi film was homogeneous and it was found that the maximum drug release in 24 h was 99.81% with formulation EF3. In vitro skin permeation study was also conducted in a modified Franz’s diffusion cell which shows that the maximum permeation with the formulation EF3 and it was 768.50 μg/cm2 after 24 h.


Conclusion: Optimized formulations were found to be suitable for formulating in terms of physicochemical characteristics and there was no significant interaction noticed between the drug and biopolymer used.

Keywords: Bioflexi film, Risperidone, Translabial,, Euryale ferox.

References

1. Satheesh NV, Yadav PA. A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate. Acta Pharm Sin B 2013;3:408-5.
2. Shen J, Choi S, Qu W, Wang Y, Burgess J D. In vitro-in vivo correlation of parenteral risperidone polymeric microsphere. J Control Release 2015;218:2-12.
3. Khalifeh S, Yassin W, Kourtian S, Boustany RM. Autism in review. J Med Liban 2016;64:110-5.
4. Park RH, Lee MJ, Moon EH, Lee SD, Paek HS. A short review on the current understandings of autism spectrum disorders. Exp Neurobiol 2016;25:1-13.
5. Sharma S, Aggarwal G, Dhawan S. Design and evaluation of olanzapine transdermal patches containing vegetable oils as permeation enhancers. Der Pharm Lett 2010;2:84-98.
6. Nair SR, Ling NT, Shukkoor MS, Manickam B. Matrix type transdermal patches of captopril: Ex vivo permeation studies through excised rat skin. J Pharm Res 2013;6:774-9.
7. Wang Y, Challa P, Epstein DL, Yuan F. Controlled release of ethacrynic acid from poly (lactide-co-glycolide) films for glaucoma treatment. Biomaterials 2004;25:4279-85.
8. Madhav NV, Yadav AP. Development and evaluation of novel repaglinide bio strips for translabial delivery. Int Res J Pharm 2013;4:198-202.
9. Gannu R, Vishnu YV, Kishan V, Rao YM. Development of nitrendipine transdermal patches: In vitro and ex vivo characterization. Curr Drug Deliv 2007;4:69-76.
10. Kusum Devi V, Saisivam S, Maria GR, Deepti PU. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm 2003;29:495-503.
11. Rajaram MD, Laxman DS. Buccal mucoadhesive films: A review. Sys Rev Pharm 2017;8:31-8.
12. Madhav NV, Kumar P, Singh B. Formulation and evaluation of venlafaxine-loaded bio-flexi film for brain specificity via oro-trans soft palatal route. Curr Med Drug Res 2017;1:1-5.
13. Suresh BS, Hemraj MT. Design and statistical optimization of mouth dissolving sublingual film of fixed dose combination of doxylamine succinate and pyridoxine hydrochloride using design of experiment in the treatment of nausea and vomiting in pregnancy. Asian J Pharm Clin Res 2018;11:202-8.
14. Mukherjee B, Kanupriya MS, Das S, Patra B. Sorbitanmonolaurate 20 as a potential skin permeation enhancer in transdermal patches. J Appl Res 2005;5:96-108.
15. Arirudran B, Janani B, Rao US. Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of Aegle marmelos attributes towards ductal carcinoma studied in MCF7 cells. Int J Pharm Pharm Sci 2019;11:21-35.
16. Ansari N, Chandel D. Antioxidant studies on methanol and aqueous extracts of Gymnosporia Montana plant. Int J Pharm Pharm Sci 2019;11:65-70.
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BHAVANA SINGH, and SATHEESH MADHAV NV. “A NOVEL APPROACH FOR DELIVERY OF RISPERIDONE USING EURYALE FEROX BIOPOLYMER FOR TRANSVERMILLION DELIVERY FOR THE MANAGEMENT OF PSYCHOSIS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 6, Apr. 2019, pp. 175-80, doi:10.22159/ajpcr.2019.v12i6.31280.
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