• KAVITA POONIAM Department of Zoology, Radiation Biology Laboratory, University of Rajasthan, Jaipur, Rajasthan, India.
  • JAIMALA SHARMA Department of Zoology, Radiation Biology Laboratory, University of Rajasthan, Jaipur, Rajasthan, India.




Opuntia elatior, Gamma radiation, Cholesterol, Mice


Objectives: Radiotherapy is deleterious to patient health by making the patient more susceptible to other diseases and often causes death by weakening the immune system and also affects cholesterol level. Based on these studies, it was moved toward the selection of Opuntia elatior as a herbal remedy for serum cholesterol level induced by gamma radiation.

Methods: The modulatory effect of O. elatior stem extract was studied in Swiss albino mice at dose, i.e., 6 Gy of gamma radiation in the presence (experimental) or absence (control) of O. elatior extract (OEE) (10 mg/kg body weight) to observe in blood cholesterol level alterations. The animals were scarified and their blood was collected at days 1, 15, and 30 post-irradiation from heart puncture. Cholesterol level was estimated by the modified method of Roeschlau et al., 1974, using kit.

Results: The cholesterol level was found almost constant in the control group (without any treatment) and increased in gamma radiation-treated group and decreased in only plant extract-treated group, whereas radiation-induced increased level of cholesterol was reduced by plant extract treatment in experimental animals (in plant extract with radiation-treated group), a normal level was achieved by day 30 post-treatment. Hence, O. elatior is beneficial to control radiation-induced blood cholesterol level.

Conclusion: Radiation-induced side effects get lowered by herbal treatment and herbal products do not have their own side effects on body on their physical and chemical processes; thus, OEE is useful to manage blood cholesterol level as an edible part, it is easy to use as treatment and in my results OEE also support to maintain cholesterol level in serum of mice.

Author Biography

KAVITA POONIAM, Department of Zoology, Radiation Biology Laboratory, University of Rajasthan, Jaipur, Rajasthan, India.

Zoology department.. Research scholar


Casserett AP. Radiation Biology. Englewood, New Jersey: Prentice Hall Inc.; 1968.

Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids. Biomed Res Int 2014;2014:480258.

Lawes CM, Hoorn SV, Law MR, Rodgers A. High cholesterol. In: Comparative Quantification of Health Risks. Geneva: Wealth Health Organization; 2003. p. 391-496.

Kusmiati FX, Dhewantara R. Cholesterol-Lowering Effect of Beta Glucan Extracted from Saccharomyces cerevisiae in Rats. Bandung, Indonesia: International Seminar on Pharmaceutics (ISP 2015); 2015.

Ma H. Cholesterol and human health. Nat Sci 2004;2:17-21.

Thomas J, Shentu TP, Singh DK. Cholesterol: Biosynthesis, functional diversity homeostasis and regulation by natural products. In: Biochemistry. London: Intech Open; 2016.

Nobel PS, Barbera G, Inglese P, Pimienta-Barrios E, editors. Agro- Ecology, Cultivation and Uses of Cactus Pear. Vol. 132. Rome: FAO-Plant Production and Protection Paper; 1995. p. 36-48.

Yasen YM, Barringer SA, Splittstoesser WE. A note on the uses of Opuntia Spp. In central/North America. J Arid Environ 1996;32:347-53.

Ahmad A, Davies J, Randall S, Skinner GR. Antiviral properties of extract of Opuntia streptacantha. Antiviral Res 1996;30:75-85.

Gurbachan S, Felker P. Cactus: New world foods. Indian Hortic 1998;43:29-31.

Jones PJ, Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY, Parsons WE, et al. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res 2000;41:697-705.

Puttaswamy NY, Asna U. In vivo antihypercholesterolemic potential of Swietenia mahagoni Leaf extract. Cholesterol 2016;2016:6.

Duangjai A, Nanteetip L, Kanittaporn T, Anan O. Effects of extraction solvents of dietary plants on lipid lowering activity. J Med Plant Res 2016;10:538-45.

Gururaja GM, Mundkinajeddu D, Kumar AS, Dethe SM, Allan JJ, Agarwal A, et al. Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats. Pharmacognosy Res 2017;9:21-6.

Lúcia BZ, Moreira YD, Dalmagro AP, Camargo A, Bini LA, Simionatto EL, et al. Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra Leaves extract An Acad Bras Ciên 2017;89:2805-15.

Galati EM, Mondello MR, Monforte MT, Galluzzo M, Miceli M, Tripodo MM. Effect of Opuntia ficus-indica (L.) Mill. Cladodes in the wound-healing process. J PACD 2003;1:16.

Ennouri M, Hamadi F, Mohamed H, Evelyne B, Hamadi A, Najiba Z. Effects of diet supplementation with cactus pear seeds and oil onserum and liver lipid parameters in rats. Food Chem 2007;101:248-53.

Jiang C, Wang Q, Wei Y, Yao N, Wu Z, Ma Y, et al. Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus Leave in hyperlipidemic mice. J Ethnopharmacol 2015;176:17-26.

Najib SZ, Wilzar F, Rani S, Berna E, Raymond T. Cholesterol-lowering effects of extract from Garcinia daedalanthera in hyperlipidemic rats. Pharmacogn J 2018;10:1125-8.

Sharma V, Singh M. Alterations induced by N-nitrosodimethylamine and ethanolic root extract of Opurculina turpethumin in serum lipid profile of male Swiss albino mice. Asian J Pharm Clin Res 2012;3:69-73.

Jain KP, Sharma P, Joshi CS. Anti-atherosclerotic activity of Elaeocarpus ganitrus Roxb. In cholesterol fed rabbits. Asian J Pharm Clin Res 2017;10:80-4.



How to Cite

POONIAM, K., and J. SHARMA. “EFFECT OF OPUNTIA ELATIOR ON CHOLESTEROL LEVEL ALTERATIONS INDUCED BY GAMMA RADIATION IN SWISS ALBINO MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 3, Mar. 2019, pp. 578-81, doi:10.22159/ajpcr.2019.v12i3.31294.



Original Article(s)