ANTIDIABETIC ACTIVITY OF BAUHINIA VAHLII Wt. and Arn. (CAESALPINIACEAE) ROOT – A BOTANICAL SOURCE FOR THE AYURVEDA DRUG MURVA
Objective: The objective of this study was to evaluate the antidiabetic potential of Bauhinia vahlii Wt. and Arn. (Caesalpiniaceae) root, a botanical source for Murva (Ayurveda drug).
Methods: Ethanol extract of B. vahlii root (EEBVR) and aqueous extract of B. vahlii root (AEBVR) prepared were subjected for acute toxicity study adopting Organisation for Economic Cooperation and Development guidelines. Antidiabetic property of EEBVR and AEBVR was screened against Streptozotocin-nicotinamide-induced Diabetes Mellitus (DM). The diabetic animals were administered with standard drug glibenclamide (0.5 mg/kg), EEBVR (200 and 400 mg/kg), and AEBVR (200 and 400 mg/kg) for 21 days. Fasting blood glucose, serum triglycerides, total cholesterol, liver malondialdehyde, reduced glutathione, and glycogen were estimated along with pancreatic histological analysis.
Results: EEBVR (400 mg/kg) exerted a marked antidiabetic activity among the extracts at the tested doses, as evidenced by considerable reversal of biochemical parameters that were well supported by the histopathological interpretation of pancreas.
Conclusion: This study confirms the antidiabetic potential of B. vahlii root and also its traditional claim in the use of DM.
2. Vaidya AD, Devasagayam TP. Current status of herbal drugs in India: An overview. J Clin Biochem Nutr 2007;41:1-11.
3. The Ayurvedic Formulary of India. Part 1. 1st ed. Delhi, India: The Controller of Publications, Government of India; 2003.
4. The Ayurvedic Pharmacopoeia of India. Part 1. 1st ed., Vol. 1. New Delhi, India: Ministry of Health and Family Welfare, Government of India; 2001.
5. Bapalal V. Some Controversial Drugs in Indian Medicine. Varanasi, India: Chaukhambha Orientalia; 1982.
6. Dugasani S, Balijepalli MK, Tandra S, Pichika MR. Antimicrobial activity of Bauhinia tomentosa and Bauhinia vahlii roots. Pharmacogn Mag 2010;6:204-7.
7. Gurudeva MR, Yoganarasimhan SN. Bibliography of medicinal plants of India (Pharmacognosy and Pharmacology). Bangalore, India: Divya Chandra Prakashana; 2009.
8. Jain SK, Rao RR. Field and Herbarium Methods. New Delhi: Today and Tomorrow Printers and Publishers; 1977.
9. Kokate CK. Practical Pharmacognosy. Delhi, India: Vallabh Prakashan; 1999.
10. OECD. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, Guidelines for the Testing of Chemicals Organization for Economical Co-Operation and Development. Paris; June, 2000, 2002.
11. Ananda PK, Kumarappan CT, Sunil C, Kalaichelvan VK. Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats. Asian Pac J Trop Biomed 2012;2:31-5.
12. Petchi RR, Vijaya C, Parasuraman S. Antidiabetic activity of polyherbal formulation in streptozotocin – Nicotinamide induced diabetic wistar rats. J Tradit Complement Med 2014;4:108-17.
13. Murali A, Ashok P, Madhavan V. Protective effects of Hemidesmus indicus var. pubescens root extract on paracetamol induced hepatic damage. Spatula DD 2012;2:51-8.
14. Murali A, Ashok P, Madhavan V. Antioxidant activity of leaf of Hemidesmus indicus (L.) R. Br. var. pubescens (W. & A.) Hk.f. (Periplocaceae) – An in vivo analysis. Spatula DD 2011;1:91-100.
15. Raja S, Ravindranadh K. In vivo antioxidant activity of Limnophila heterophylla and Michelia champaca. IJPPS 2017;9:241-6.
16. Oyedemi S, Bradley G, Afolayan A. Antidiabetic activities of aqueous stem bark extract of strychnoshenningsii gilg in streptozotocin-nicotinamide type 2 diabetic rats. Iran J Pharm Res 2012;11:221-8.
17. Attanayake AP, Jayatilaka KA, Pathirana C, Mudduwa LK. Study of antihyperglycaemic activity of medicinal plant extracts in alloxan induced diabetic rats. Anc Sci Life 2013;32:193-8.
18. Kumar R, Pate DK, Prasad SK, Sairam K, Hemalatha S. Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats. Asian Pac J Trop Med 2011;4:904-9.
19. Belhekar Santosh N, Chaudhari Pravin D, Pandhare Ramdas B, Pawar Anil R. Effect of polyherbal and allopolyherbal formulation on streptozotocin-nicotinamide induced diabetic nephropathy in rats. Int J Toxicol Pharmacol Res 2016;8:138-45.
20. Shukla K, Dikshit P, Shukla R, Gambhir JK. The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats. J Med Food 2012;15:718-25.
21. Elshamy A. Antidiabetic and antioxidant activities of phenolic extracts of Conyza dioscoridis (L.) shoots. Int J Pharm Pharm Sci 2015;7:65-72.
22. Vinayagam R, Jayachandran M, Xu B. Antidiabetic effects of simple phenolic acids: A comprehensive review. Phytother Res 2016;30:184 99.
23. Prabu M, Kumuthakalavalli R. Antidiabetic potential of the oyster mushroom Pleurotus florida (Mont.) singer. Int J Curr Pharm Res 2017; 9:51-4.
24. Singh S, Farswan M, Ali S, Afzal M, Al-Abbasi FA, Kazmi I, et al. Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate. Pharm Biol 2014;52:750-5.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.