• KAMALRAJ R PEH R and D, Pfizer Inc., Chennai, Tamil Nadu, India.
  • SUBHASHREE G R Department of Physics, Dr. MGR Educational and Research Institute, Chennai, Tamil Nadu, India.


Objective: The objective of the study was to investigate the memory-enhancing activity for erythrinine (ring-c-oxygenated Erythrina alkaloid) from leaf extract of Erythrina indica in mice.

Methods: The study protocol designed in the way that it was carried out for 21 successive days by administrating the 5 mg/kg, s.c doses of isolated erythrinine to mice and the profile was challenged against the mice feeds with normal saline as a positive control and the mice treated with 5 mg/kg, s.c corticosterone as a negative control for the amnesia using Morris water maze test method.

Results: Erythrinine-administered mice are showing remarkable retention of the memory (9.07±0.52) on the 21st day as such of the positive control normal saline (10.14±0.22) and against the negative control corticosterone-injected mice (70.86±0.54).

Conclusions: The dose of 5 mg/kg s.c of isolated erythrinine from the leaf of E. indica shows the remarkable memory enhancement when it was investigated with the memory weakening induced test by corticosterone in mice’s using 5 mg/kg s.c. However, further studies required to elucidate the exact mechanism of action for developing its as potent memory-enhancing drug.

Keywords: Erythrinine, Memory enhancing, Amnesia.


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How to Cite
KAMALRAJ R, and SUBHASHREE G R. “EVALUATION OF MEMORY-ENHANCING ACTIVITY FOR ERYTHRININE FROM LEAF EXTRACT OF ERYTHRINA INDICA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 5, Mar. 2019, pp. 101-3, doi:10.22159/ajpcr.2019.v12i5.32052.
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