EVALUATION OF MEMORY-ENHANCING ACTIVITY FOR ERYTHRININE FROM LEAF EXTRACT OF ERYTHRINA INDICA

  • KAMALRAJ R PEH R and D, Pfizer Inc., Chennai, Tamil Nadu, India.
  • SUBHASHREE G R Department of Physics, Dr. MGR Educational and Research Institute, Chennai, Tamil Nadu, India.

Abstract

Objective: The objective of the study was to investigate the memory-enhancing activity for erythrinine (ring-c-oxygenated Erythrina alkaloid) from leaf extract of Erythrina indica in mice.


Methods: The study protocol designed in the way that it was carried out for 21 successive days by administrating the 5 mg/kg, s.c doses of isolated erythrinine to mice and the profile was challenged against the mice feeds with normal saline as a positive control and the mice treated with 5 mg/kg, s.c corticosterone as a negative control for the amnesia using Morris water maze test method.


Results: Erythrinine-administered mice are showing remarkable retention of the memory (9.07±0.52) on the 21st day as such of the positive control normal saline (10.14±0.22) and against the negative control corticosterone-injected mice (70.86±0.54).


Conclusions: The dose of 5 mg/kg s.c of isolated erythrinine from the leaf of E. indica shows the remarkable memory enhancement when it was investigated with the memory weakening induced test by corticosterone in mice’s using 5 mg/kg s.c. However, further studies required to elucidate the exact mechanism of action for developing its as potent memory-enhancing drug.

Keywords: Erythrinine, Memory enhancing, Amnesia.

References

1. Burns A, Life S. Alzheimer’s disease. BMJ 2009;338:b158.
2. World Health Organization. Dementia Fact sheet N 362. Geneva: World Health Organization; 2015.
3. Pratap GK, Ashwini S, Shantaram M. Alzheimer’s disease: A challenge in managing with certain medicinal plants-a review. IJPSR 2017; 8:4960 72.
4. National Institute on Aging. Alzheimer’s Disease Diagnostic Guidelines; 2011.
5. Querfurth HW, LaFerla FM. Alzheimer’s disease. N Engl J Med 2010;362:329-44.
6. NICE. Dementia Diagnosis and Assessment. UK: National Institute for Health and Care Excellence (NICE); 2014.
7. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E, et al. Alzheimer’s disease. Lancet 2011;377:1019-31.
8. Todd S, Barr S, Roberts M, Passmore AP. Survival in dementia and predictors of mortality: A review. Int J Geriatr Psychiatry 2013;28:1109 24.
9. Anonymous. University of Florida: Environmental Horticulture; 2008.
10. Subhashini N, Nagarajan G, Kavimani S. In vitro antioxidant and anticholinesterase activities of Garcinia combogia. Int J Pharm Pharm Sci 2011;3:129-32.
11. Krishna VR, Tejaswini G. Anti-inflammatory activity of Erythrina variegata. Int J Pharm Pharm Sci 2015;7:386-8.
12. Kamalraj R, Muthukumar VA. Effect of Erythrina indica on stress induced alteration on lipid profile in rats. Asian Pacific J Trop Dis 2012;2:S949-51.
13. Srinivasan N, Sriram N, Mandtry S, Kumar SA, Yashoda K. Memory enhancing activity of Erythrina variegate on corticosterone induced dementia in mice. Int J Pharmacol Screen Methods 2013;3:72-6.
14. Ito K, Haruna M, Jinno, Furukawa. The alkaloids: Chemistry and pharmacology. H Chem Phurm Bull 1976;24:52.
15. Dagne E, Steglich W. 8-oxoerythrinine: An alkaloid from Erythrina brucei. Phytochemistry 1984:23;449-51.
16. Ito K, Haruna M, Furukawa J. The isoquinoline alkaloids chemistry and pharmacology. J Chem Sot Chem Commun 1970;1076:119.
17. Wang J, Zhang HY, Tang XC. Cholinergic deficiency involved in vascular dementia, possible mechanism and strategy of treatment. Acta Pharmacol Sin 2009;30:1671-4083.
18. Rubio J, Dang H, Gong M, Liu X, Chen SL, Gonzales GF, et al. Aqueous and hydroalcoholic extracts of black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol 2007;45:1882-90.
Statistics
186 Views | 46 Downloads
How to Cite
KAMALRAJ R, and SUBHASHREE G R. “EVALUATION OF MEMORY-ENHANCING ACTIVITY FOR ERYTHRININE FROM LEAF EXTRACT OF ERYTHRINA INDICA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 5, Mar. 2019, pp. 101-3, https://innovareacademics.in/journals/index.php/ajpcr/article/view/32052.
Section
Original Article(s)