• SRIRAM BS Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru -575 008, Karnataka India.
  • RAVICHANDRA V Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru -575 008, Karnataka India.


Objective: The objective of the study was to evaluate the antidepressant activity of quercetin in monosodium glutamate (MSG) model of depressed male mice.

Methods: MSG was administered (500 mg/kg) to different groups of albino male mice daily for 21 days to induce depression. The interventions (Quercetin and imipramine) were started on day 9th and continued till 21st day. On 23rd day, mice are sacrificed, hippocampus and amygdala supernatant are subjected for analysis. p<0.05 was considered as statistically significant.

Results: There was a statistically significant reduction in interleukin (IL)-6 levels in animals treated with quercetin and imipramine compared to control group (p<0.001). There was also a statistically significant increase in brain-derived neurotrophic factor (BDNF) levels in quercetin with MSG groups (p<0.05) and imipramine with MSG groups (p<0.01). There was no statistically significant difference in IL-6 and BDNF levels between the groups of animals treated with quercetin (100 mg/kg) and imipramine (10 mg/kg) alone.

Conclusion: Quercetin appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of quercetin in behavioral disorders such as depression.

Keywords: Monosodium glutamate, Quercetin, Imipramine, Interleukin-6, Brain-derived neurotrophic factor.


1. Rihmer Z, Angst J. Mood disorders: Epidemiology. In: Sadock BJ, Sadock VA, editors. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 8th ed. Philadelphia, PA: Lippincott, Williams and Wilkins; 2005. p. 1576-82.
2. Mayou RA, Gill D, Thompson DR, Day A, Hicks N, Volmink J, et al. Depression and anxiety as predictors of outcome after myocardial infarction. Psychosom Med 2000;62:212-9.
3. Bottomley A. Depression in cancer patients: A literature review. Eur J Cancer Care (Engl) 1998;7:181-91.
4. Aithal S, Hooli TV, Patil R, Varun HV, Swetha ES. Evaluation of antidepressant activity of topiramate in mice. Asian J Pharm Clin Res 2014;7:174-6.
5. Torgal SS, Amitha N. An experimental study evaluating the influence of bisphosphonates on depression patterns in swiss albino mice and Wister rats. Int J Pharm Pharm Sci 2017;9:187-91.
6. Umukoro S, Oluwole GO, Olamijowon HE, Omogbiya AI, Eduviere AT. Effect of Monosodium glutamate on behavioral phenotypes, biomarkers of oxidative stress in brain tissues and liver enzymes in mice. World J Neurosci 2015;5:339-49.
7. Abrahamse SL, Kloots WJ, van Amelsvoort JM. Absorption, distribution, and secretion of epicatechin and quercetin in the rat. Nutr Res 2005;25:305-17.
8. Kawabata K, Mukai R, Ishisaka A. Quercetin and related polyphenols: New insights and implications for their bioactivity and bioavailability. Food Funct 2015;6:1399-417.
9. Guo Y, Bruno RS. Endogenous and exogenous mediators of quercetin bioavailability. J Nutr Biochem 2015;26:201-10.
10. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81:230S-242S.
11. de Boer VC, Dihal AA, van der Woude H, Arts IC, Wolffram S, Alink GM, et al. Tissue distribution of quercetin in rats and pigs. J Nutr 2005;135:1718-25.
12. Ruotolo R, Calani L, Brighenti F, Crozier A, Ottonello S, Del Rio D, et al. Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell model systems. Arch Biochem Biophys 2014;559:62-7.
13. Molinoff PB. Neurotransmission and central nervous system. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw Hill; 2011. p. 364-81.
14. Ghosh MN. Fundamentals of Experimental Pharmacology. 5th ed. Kolkota: Hilton and Company; 2011. p. 165-72.
15. Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H, et al. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine 1997;9:853-8.
16. Garcia LS, Comim CM, Valvassori SS, Réus GZ, Barbosa LM, Andreazza AC, et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:140-4.
17. Sidney H. Kennedy, Rizvi SJ. Comparative efficacy of newer antidepressants for major depression: A Canadian perspective. Can J Diagn 2009;20:81-6.
18. Tanwani H, Nyati P, Atal S, Churihar R. Evaluation of antianxiety, antidepressant and sedative effects of nimodipine in Swiss albino mice. Int J Pharm Pharm Sci 2016;8:260-3.
19. Zhou H, Zhang H, Cui J, Liu Y, Wu R, Xiang H. Protoponaxidiol saponins in the caudexes and leaves of Panax notoginseng could be the main constituents for its antidepressant effects. Int J Pharm Pharm Sci 2014;6:301-1.
20. Xia SF, Xie ZX, Qiao Y, Li LR, Cheng XR, Tang X, et al. Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress. Physiol Behav 2015;138:325-31.
21. Arredondo F, Echeverry C, Abin-Carriquiry JA, Blasina F, Antúnez K, Jones DP, et al. After cellular internalization, quercetin causes nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic Biol Med 2010;49:738-47.
22. Bureau G, Longpré F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res 2008;86:403-10.
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How to Cite
SRIRAM BS, and RAVICHANDRA V. “AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF QUERCETIN ON MONOSODIUM GLUTAMATE-INDUCED DEPRESSION IN SWISS ALBINO MALE MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 5, Apr. 2019, pp. 292-4, doi:10.22159/ajpcr.2019.v12i5.32986.
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