EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ARTHRITIC POTENTIAL OF FRACTIONS OF ECLIPTA PROSTRATA LINN

  • HITESH MALHOTRA Department of Pharmaceutical Sciences, Chandigarh College of Pharmacy, Ajitgarh, Punjab, India.
  • MANJUSHA CHOUDHARY 2Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India.

Abstract

Objective: The objective of the study was to establish the anti-inflammatory and anti-arthritic potential of various fractions of Eclipta prostrata Linn.


Methods: The four fractions, i.e., n-butanol, ethyl acetate, chloroform, and n-hexane from hydro-alcoholic extract were obtained. First, the fractions were evaluated through in vitro models, and then they were evaluated by in vivo anti-inflammatory model, i.e., carrageenan-induced paw edema model. Further, two active fractions were evaluated for the anti-arthritic activity using formaldehyde induced arthritis model.


Results: The fractions at a dose of 100 and 200 mg/kg showed an anti-inflammatory activity, but the ethyl acetate and chloroform fraction will show maximum anti-inflammatory potential. Hence, they are further evaluated for anti-arthritic potential where they show significant activity.


Conclusion: From the results, it is concluded that the ethyl acetate and chloroform fraction show significant anti-arthritic activity.

Keywords: Inflammation,, Arthritis,, Eclipta prostrata,, Wedelolactone.

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How to Cite
HITESH MALHOTRA, and MANJUSHA CHOUDHARY. “EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ARTHRITIC POTENTIAL OF FRACTIONS OF ECLIPTA PROSTRATA LINN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, May 2019, pp. 158-66, https://innovareacademics.in/journals/index.php/ajpcr/article/view/33009.
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