EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ARTHRITIC POTENTIAL OF FRACTIONS OF ECLIPTA PROSTRATA LINN

HITESH MALHOTRA; MANJUSHA CHOUDHARY

doi:10.22159/ajpcr.2019.v12i7.33009

Authors

HITESH MALHOTRA Department of Pharmaceutical Sciences, Chandigarh College of Pharmacy, Ajitgarh, Punjab, India.
MANJUSHA CHOUDHARY 2Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i7.33009

Keywords:

Inflammation,, Arthritis,, Eclipta prostrata,, Wedelolactone

Abstract

Objective: The objective of the study was to establish the anti-inflammatory and anti-arthritic potential of various fractions of Eclipta prostrata Linn.

Methods: The four fractions, i.e., n-butanol, ethyl acetate, chloroform, and n-hexane from hydro-alcoholic extract were obtained. First, the fractions were evaluated through in vitro models, and then they were evaluated by in vivo anti-inflammatory model, i.e., carrageenan-induced paw edema model. Further, two active fractions were evaluated for the anti-arthritic activity using formaldehyde induced arthritis model.

Results: The fractions at a dose of 100 and 200 mg/kg showed an anti-inflammatory activity, but the ethyl acetate and chloroform fraction will show maximum anti-inflammatory potential. Hence, they are further evaluated for anti-arthritic potential where they show significant activity.

Conclusion: From the results, it is concluded that the ethyl acetate and chloroform fraction show significant anti-arthritic activity.

Downloads

Download data is not yet available.

References

Winslow LC, Kroll DJ. Herbs as medicine. Arch Internal Med 1998;158:2192-9.

Mudur G. Panel defends India’s traditional doctors. Br Med J 1997;314:1573.

Vickers A, Zollman C. ABC of complementary medicine: Herbal medicine. Br Med J 1999;319:1050-3.

Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.

Kamboj VP. Herbal medicine. Curr Sci 2000;78:35-9.

Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum 2005;34:773-84.

Trease GE, Evans WC. Textbook of Pharmacognosy. 13th ed. Oxford: Alden Press; 1989.

Chippada SC, Vanaspati M. Antioxidant, an anti-inflammatory and anti-arthritic activity of Centella asiatica extracts. J Chem Biol Phys Sci 2011;1:260-9.

Vogel HG. Drug Discovery and Evaluations. 2nd ed. New York: Springer-Verlag Berlin Heidelberg; 2002.