• LATIF MS Department of Technology and Natural Resources, Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia Kampus Pagoh, KM1, Jalan Panchor, 84000 Muar, Johor, Malaysia.
  • ABBAS S Department of Technology and Natural Resources, Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia Kampus Pagoh, KM1, Jalan Panchor, 84000 Muar, Johor, Malaysia.
  • KORMIN F Department of Technology and Natural Resources, Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia Kampus Pagoh, KM1, Jalan Panchor, 84000 Muar, Johor, Malaysia.
  • MUSTAFA MK Department of Technology and Natural Resources, Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia Kampus Pagoh, KM1, Jalan Panchor, 84000 Muar, Johor, Malaysia.


The use of metal nanoparticles (MNPs) in various fields is increasing day-by-day leading to a genuine concern about the issues related to their environmental and biological safety. The major approaches for the synthesis of NPs include physical and chemical methods which are expensive and hazardous to health in addition to being toxic to the environment. This review highlights the potential of plant extracts to carry out the synthesis of MNPs with a special emphasis on the role of flavonoids in nanosynthesis. This green and clean approach have been actively utilized in recent years as an alternative to conventional hazardous approaches. It has proved as cost-effective, non-toxic, less time and labor consuming, efficient, and eco-friendly method for the synthesis of MNPs with specific biological actions. This review also focuses on the role of polyphenols, including the flavonoids as bioreductants of metal salts for the synthesis of NPs along with their biomedical applications. Various examples of the MNPs, along with their biological actions, have also been summarized.

Keywords: Green synthesis,, Metal nanoparticles,, Polyphenols,, Flavonoids,, Plant extract.


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How to Cite
LATIF MS, ABBAS S, KORMIN F, and MUSTAFA MK. “GREEN SYNTHESIS OF PLANT-MEDIATED METAL NANOPARTICLES: THE ROLE OF POLYPHENOLS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, June 2019, pp. 75-84, doi:10.22159/ajpcr.2019.v12i7.33211.
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