EFFECTS OF PSYCHOTROPICS ON NEUTROPHIL-LYMPHOCYTE RATIO IN PSYCHIATRIC PATIENTS
Psychotropics on psychiatric patients.
Objective: The objective of this study was to investigate whether psychotropic has any effect on neutrophils and lymphocyte ratio (NLR) in psychiatric patients.
Methods: In this hospital-based prospective quasi-randomized follow-up study, we analyzed every 10 patients with newly diagnosed with depression, schizophrenia, and bipolar disorder for complete blood count before and after treatment with the selected psychotropic.
Results: There was a significant increase in NLR of patients with depression after treatment with psychotropic (p=0.001), also in schizophrenia, there was a slight increase in NLR of patients after treatment with psychotropic (p=0.005), but in bipolar disorder, there was a significant decrease in NLR of patients after treatment with psychotropic (p=0.002).
Conclusion: The present study confirmed that psychotropics have a statistically significant effect on the increase in NLR in patients with depression, a slight increase in patients with schizophrenia, and a decrease in patients with bipolar disorder. Further studies are needed for a better understanding of the mechanism of psychotropic drug effect on NLR.
2. Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010;105:186-91.
3. Halazun KJ, Aldoori A, Malik HZ, Al-Mukhtar A, Prasad KR, Toogood GJ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008;34:55-60.
4. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102:653-7.
5. Aydin Sunbul E, Sunbul M, Yanartas O, Cengiz F, Bozbay M, Sari I, et al. Increased neutrophil/Lymphocyte ratio in patients with depression is correlated with the severity of depression and cardiovascular risk factors. Psychiatry Investig 2016;13:121-6.
6. Ebmeier KP, Donaghey C, Steele JD, Association AP, Kessler R, Berglund P, et al. Recent developments and current controversies in depression. Lancet (London, England) 2006;367:153-67.
7. World Health Organization. The World Health Report: 2001. Mental Health: New Understanding, New Hope. Geneva: World Health Organization; 2001.
8. Canan F, Ataoglu A. Effect of escitalopram on white blood cells in patients with major depression. J Clin Med Res 2009;1:290-1.
9. Semiz M, Yildirim O, Canan F, Demir S, Hasbek E, Tuman TC, et al. Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiatr Danub 2014;26:220-5.
10. Rothermundt M, Arolt V, Bayer TA. Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 2001;15:319-39.
11. Ayhan MG, Cicek IE, Inanli I, Caliskan AM, Ercan SK, Eren I. Neutrophil/ lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder. Psychiatry Clin Psychopharmacol 2017;27:284-8. Available from:http://www.ovidsp.ovid.com/ovidweb.cgi?T=JS& PAGE=reference &D=psyc14&NEWS=N&AN=2018-16725-012.
12. Çak?r U, Tuman TC, Y?ld?r?m O. Increased neutrophil/lymphoctye ratio in patients with bipolar disorder: A preliminary study. Psychiatr Danub 2015;27:180-4.
13. Zam WI. Vitamin D deficiency and depressive disorders: Review study of probable relationship. Int J Pharm Pharm Sci 2016;8:16-22.
14. Ilyaz M, Baig MM, Quadir MA, Fathima M, Khan SA. Drug utilization study of antipsychotics and its common ADR’S in the psychiatry OPD of OHRC. Int J Pharm Pharm Sci 2014;6:162-5.
15. Oyewumi LK, McKnight M, Cernovsky ZZ. Lithium dosage and leukocyte counts in psychiatric patients. J Psychiatry Neurosci 1999;24:215-21.
16. Korkmaz S, Denk A, Gundogani B, Korucu T, Dulkadir ZE, Telo MS. Atmaca. neutrophil lymphocyte ratio in patients with major depressive disorder. Acta Med Mediterr 2016;32:795-8.
17. Çak?r U, Tuman TC, Y?ld?r?m O. Increased neutrophil/lymphoctye ratio in patients with bipolar disorder: A preliminary study. Psychiatr Danub 2015;27:180-4. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/26057314.
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