EFFECTS OF PSYCHOTROPICS ON NEUTROPHIL-LYMPHOCYTE RATIO IN PSYCHIATRIC PATIENTS: Psychotropics on psychiatric patients.

RAJESH VENKATARAMAN; MUHAMMED RASHID; AKHILA G; SHIJO DANIEL; AMALATHOMAS

doi:10.22159/ajpcr.2019.v12i6.33251

Authors

RAJESH VENKATARAMAN Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.
MUHAMMED RASHID Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.
AKHILA G Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.
SHIJO DANIEL Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.
AMALATHOMAS Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i6.33251

Keywords:

Lymphocytes,, Neutrophils,, Neutrophilslymphocyte ratio,, Bipolar disorder,, Schizophrenia,, Depression

Abstract

Objective: The objective of this study was to investigate whether psychotropic has any effect on neutrophils and lymphocyte ratio (NLR) in psychiatric patients.

Methods: In this hospital-based prospective quasi-randomized follow-up study, we analyzed every 10 patients with newly diagnosed with depression, schizophrenia, and bipolar disorder for complete blood count before and after treatment with the selected psychotropic.

Results: There was a significant increase in NLR of patients with depression after treatment with psychotropic (p=0.001), also in schizophrenia, there was a slight increase in NLR of patients after treatment with psychotropic (p=0.005), but in bipolar disorder, there was a significant decrease in NLR of patients after treatment with psychotropic (p=0.002).

Conclusion: The present study confirmed that psychotropics have a statistically significant effect on the increase in NLR in patients with depression, a slight increase in patients with schizophrenia, and a decrease in patients with bipolar disorder. Further studies are needed for a better understanding of the mechanism of psychotropic drug effect on NLR.

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Author Biography

RAJESH VENKATARAMAN, Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.

Associate prof and Head,

Department of Pharmacy Practice.

Sri Adichunchanagiri college of Pharmacy,

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