DRUG UTILIZATION EVALUATION OF ANTIBIOTICS IN THE DEPARTMENT OF PAEDIATRICS IN COMPLIANCE WITH THE WHO PRESCRIBING INDICATORS

  • POTLAPALLY NIKHITHA SRI Department of Pharmacy Practice, Care College of Pharmacy, Warangal, Telangana, India.
  • MOHAMMAD YOUNUS MOHIUDDIN Department of Pharmacy Practice, Shadan College of Pharmacy, Hyderabad, Telangana, India.

Abstract

Objective: The objective of this study is to analyze the drug utilization pattern of antibiotics according to the World Health Organization (WHO) prescribing indicators at an outpatient department of pediatrics.


Methods: This is a prospective observational study conducted in an outpatient department of pediatrics in a private hospital located in Telangana, India. Study data were obtained from patient prescriptions and direct interview of the caretaker/patient.


Results: Data have been collected from 295 pediatric patients, out of which 177 were male, the highest number of patients was reported in the age group of 1–4 years. Most of the patients presented with lower respiratory tract infection, acute gastroenteritis, and fever. Most of the prescriptions included ceftriaxone, amoxicillin + clavulanic acid, and quinolones among antibiotics.


Conclusion: Most of the prescriptions were in accordance with the essential list of medicine for children given by the WHO, but the number of drug-drug interactions in the prescriptions were significant, which can be simply prevented by following standard therapeutic guidelines and by establishing a role of clinical pharmacist in the hospitals.

Keywords: Pediatrics,, World health organization prescribing indicators,, Lower respiratory tract infections,, Acute gastroenteritis,, Drug-drug interactions.

References

1. Palikhe N. Prescribing pattern of antibiotics in pediatric hospital of Kathmandu valley. J Nepal Health Res Council 2004;2:31-6.
2. Lee D, Bergman U. Studies of utilization. In: Strom BL, editor. Pharmacoepidemiology. New York: Churchill Livingstone; 1989. p. 259-74.
3. Parthasarathi G, Karin NH, Milap C. A Text Book of Clinical Pharmacy Practice. Essential Concepts Skills; 2005. p. 364-71.
4. Straand J, Rokstad K, Heggedal U. Drug prescribing for children in general practice. A report from the møre and romsdal prescription study. Acta Paediatr 1998;87:218-24.
5. Ghai OP, Paul VK. Rational drug therapy in pediatric practice. Indian Pediatr1 988;25:1095-109.
6. Walson PD. Paediatric clinical pharmacology and therapeutics. In: Speight TM, Holford NH, editors. Avery?s Drug Treatment. Auckland: ADIS International; 1997. p. 127-223.
7. Antibiotics. NHS; 2014. Available from: https://www.nhs.uk/conditions/antibiotics/. [Last accessed on 2015 Jan 17].
8. Factsheet for Experts. European Centre for Disease Prevention and Control. Available from: https://ecdc.europa.eu/en/antimicrobial-resistance/facts/factsheets/general-public. [Last accessed on 2014 Dec 21].
9. Metronidazole. The American Society of Health-System Pharmacists. Available from: https://www.drugs.com/monograph/metronidazole.html. [Last accessed on 2015 Jul 31].
10. Wang J. Chemical Analysis of Antibiotic Residues in Food (PDF). John Wiley and Sons, Inc.; 2012. p. 1-60.
11. Golkar Z, Bagasra O, Pace DG. Bacteriophage therapy: A potential solution for the antibiotic resistance crisis. J Infect Dev Ctries 2014;8:129-36.
12. Gould IM, Bal AM. New antibiotic agents in the pipeline and how they can help overcome microbial resistance. Virulence 2013;4:185-91.
13. Wright GD. Something old, something new: Revisiting natural products in antibiotic drug discovery. Can J Microbiol 2014;60:147-54.
14. Sengupta S, Chattopadhyay MK, Grossart HP. The multifaceted roles of antibiotics and antibiotic resistance in nature. Front Microbiol 2013;4:47.
15. Centers for Disease Control and Prevention, Office of Infectious Disease. United States: Antibiotic Resistance Threats in the United States; 2013. Available from: http://www.cdc.gov/drugresistance/threat-report-2013. [Last accessed on January 28, 2015.
16. Congressional Research Service Report. United States: Life expectancy in the United States; 2005. Available at: http://www.cnie.org/nle/crsreports/05mar/RL32792.pdf. [Last accessed on 2015 Jan 05].
17. Ramanath KV, Balaji B. Study the outpatients prescription pattern of antibiotics in paediatric populations of two hospitals. Arch Pharma Pract 2013;4:21-7.
18. Malpani AK, Waggi M, Rajbhandari A, Kumar GA, Nikitha R, Chakravarthy AK. Study on prescribing pattern of antibiotics in a pediatric out-patient department in a tertiary care teaching and non-teaching hospital. Indian J Pharm Pract 2016;9:253-9.
19. Global Antibiotic Resistance Partnership (GARP) India Working Group. Rationalizing Antibiotic use to Limit Antibiotic Resistance in India. Ind J Med Res 2011;134:281-94.
20. Venkateswaramurthy N, Murali R, kumar SR. The study of drug utilization pattern in paediatricspatients. Int J Pharm Pharm Sci 2013;5.
21. Amane H, Priyadarshini K. Prescription analysis to evaluate the rational use of antibiotics. Int J Pharm Bio Sci 2011;2:314-9.
22. Uppal R, Chhabra A, Narang A. Pattern of drug use in neonatal intensive care unit. Indian Pediatr 1998;35:647-9.
23. Turner S, Longworth A, Nunn AJ, Choonara I. Unlicensed and off label drug use in paediatric wards: Prospective study. BMJ 1998;316:343-5.
24. Chavda DA, Mistry RA, Solanki KC, Suthar SD, Desai BL, Mistry SD. Drug utilization study in the inpatients of paediatric department of a tertiary care hospital. Int J Basic Clin Pharmacol 2015;4:729-33.
25. Maheshwari P, Ravichandiran V, Kumar KH, Sreelekha KV, Baig TA, Shahel SN. Prescribing patterns of antibiotics in paediatrics for respiratory tract infections/disorders in tertiary care hospital. Asian J Pharm Clin Res 2015;8:259-61.
26. Palikhe N. Prescribing pattern of antibiotics in paediatric hospitals in Kathmandu valley. Kathmandu Univ Med J 2004;2:6-12.
27. Shankar PR, Upadhyay DK, Subish P, Dubey AK, Mishra P. Prescribing patterns among paediatric inpatients in a teaching hospital in western Nepal. Singapore Med J 2006;47:261-5.
28. Rauniar GP, Rani MA, Das BP. Prescribing pattern of antimicrobial agents in paediatric in-patients. J Nepalgunj Med Coll 2003;3:34-7.
29. Ashraf H, Handa S, Khan NA. Prescribing pattern of drugs in outpatient department of child care centre in Moradabad city. Int J Pharm Sci Rev Res 2010;3:1-5.
30. Gopal DV, Krishna TR, Kumar AS. Meda VS, Reddy KR. Prescribing pattern of antibiotics in the general medicine and pediatrics departments of a tertiary care teaching hospital. Int J Pharm Pharm Sci 2014;6:221-4.
31. World Health Organization. 4th WHO Model List of Essential Medicines for Children’s; 2013. Available from: https://www.who.int/medicines/publications/essentialmedicines/4th_EMLc_FINAL_web_8Jul13.pdf.
32. Senthilselvi R, Boopana M, Sathyan L, Visuvasam P, Ganesan V. Drug utilization pattern in paediatric patients in a secondary care hospital. Int J Pharm Pharm Sci 2019;11:69-74.
33. Sunil KM, Sanjay S, Arun KS, Reena M. Prescribing pattern of antimicrobials in pediatric outpatient department of tertiary care teaching hospital, Ajmer (Rajasthan). Int J Pharm Toxicol Sci 2013;3:40-6.
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POTLAPALLY NIKHITHA SRI, and MOHAMMAD YOUNUS MOHIUDDIN. “DRUG UTILIZATION EVALUATION OF ANTIBIOTICS IN THE DEPARTMENT OF PAEDIATRICS IN COMPLIANCE WITH THE WHO PRESCRIBING INDICATORS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 6, Apr. 2019, pp. 98-101, doi:10.22159/ajpcr.2019.v12i6.33366.
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