EFFECT OF INTRATHECAL HEAVY BUPIVACAINE WITH DEXMEDETOMIDINE AND INTRATHECAL HEAVY BUPIVACAINE WITH FENTANYL IN LOWER ABDOMINAL AND GYNAECOLOGICAL SURGERIES

  • SURESH MALLA Department of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh, India.
  • PRANJAL SINGH GUPTA Department of Anaesthesiology, GSL Medical College, Rajahmundry, Andhra Pradesh, India.
  • DIVYA AGRAWAL Department of Anatomy, GSL Medical College, Rajahmundry, Andhra Pradesh, India.
  • RASMIREKHA BEHERA Department of Pharmacology, Institute of Medical Sciences and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
  • SANJAY KUMAR SANJAY KUMAR1*

Abstract

Objective: Spinal or epidural anesthesia techniques provide the best method of anesthesia for lower abdominal and lower limb surgeries. Small doses of adjuvants administered spinally provide profoundly prolonged segmental analgesia with good post-operative pain relief. The objective of the present study is to evaluate the efficacy of dexmedetomidine (10 μg) versus fentanyl (25 μg) as an adjuvant added to bupivacaine in spinal anesthesia for patients undergoing lower abdominal and gynecological surgeries and assessment of duration of post-operative analgesia.


Methods: Hospital-based randomized double-blind controlled study conducted in tertiary teaching hospital of Kakinada and Rajahmundry. The period of study is February 2013–July 2018. Patients were divided into two groups of 25 each. In the first group, dexmedetomidine was added as adjuvant to bupivacaine whereas in the second group fentanyl was added as an adjuvant to bupivacaine. The visual analog scale used to assess the analgesic effect. Time at which the rescue analgesic given was noted which gives the duration of post-operative analgesia.


Results: Results were analyzed in both groups. The software used for statistical analysis was GraphPad for windows 10.0.5. Continuous variables were analyzed with student t-test and analysis of variance. Post-operative analgesia duration is significantly prolonged in the dexmedetomidine group with a mean 308.64±12.50 compared to fentanyl group where the mean is 253.12 min±14.30. There is a statistically significant difference (p<0.0001) between the two groups.


Conclusion: Intrathecal dexmedetomidine supplementation to spinal bupivacaine seems to be a good alternative to intrathecal fentanyl since it produces prolonged post-operative analgesia with minimal side effects and excellent quality of spinal analgesia.

Keywords: Spinal anesthesia,, Adjuvants,, Post-operative analgesia,, Visual analog scale,, Intrathecal route.

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SURESH MALLA, PRANJAL SINGH GUPTA, DIVYA AGRAWAL, RASMIREKHA BEHERA, and SANJAY KUMAR. “EFFECT OF INTRATHECAL HEAVY BUPIVACAINE WITH DEXMEDETOMIDINE AND INTRATHECAL HEAVY BUPIVACAINE WITH FENTANYL IN LOWER ABDOMINAL AND GYNAECOLOGICAL SURGERIES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 6, May 2019, pp. 271-5, https://innovareacademics.in/journals/index.php/ajpcr/article/view/33469.
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