EFFECT OF ULTRA-DILUTED HISTAMINE ON HYPOXIC CHICK LUNG TISSUE INFLAMMATORY CHANGES

  • PRITAM GOSWAMI Department of Pathology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
  • SWAIF ALI SK Department of Pathology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
  • SAYAK GHOSH Department of Pathology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
  • ANAMIKA BASU Department of Pathology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
  • JOYDEEP KHANRA Department of Pathology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
  • SATADAL DAS Department of Microbiology, Peerless Hospital and B K Roy Research Centre, Kolkata, West Bengal, India.

Abstract

Objectives: Since its discovery, the role of histamine in inflammation is controversial; thus, according to some authority, it is mainly pro-inflammatory, and according to others, it is anti-inflammatory in nature. In this scenario, we thought that the contradictory results are dose dependent, thus in this study, our aim was to find the specific role of ultra-diluted histamine in pulmonary inflammation.


Materials and Methods: Ultra-diluted histamine ( ~1 pg/ml) was administered in chick lung hypoxic inflammation in an restricted organoid culture along with lysozyme, ovalbumin, and blank controls.


Results: The ultra-diluted histamine showed a significant role as an anti-inflammatory and bronchodilator agent and the anti-inflammatory action was found similar to lysozyme.


Conclusion: Ultra-diluted histamine may be used as an anti-inflammatory agent.

Keywords: Ultra-diluted histamine,, Anti-inflammatory agent,, Ovalbumin,, Lysozyme,, Hypoxia.

Author Biography

SATADAL DAS, Department of Microbiology, Peerless Hospital and B K Roy Research Centre, Kolkata, West Bengal, India.

Principal Investigator,

Virology Laboratory

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PRITAM GOSWAMI, SWAIF ALI SK, SAYAK GHOSH, ANAMIKA BASU, JOYDEEP KHANRA, and SATADAL DAS. “EFFECT OF ULTRA-DILUTED HISTAMINE ON HYPOXIC CHICK LUNG TISSUE INFLAMMATORY CHANGES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, May 2019, pp. 199-02, https://innovareacademics.in/journals/index.php/ajpcr/article/view/33651.
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