• GOWHER GUNA Department of Botany, Islamia College of Science and Commerce, Hawal, Srinagar, India.


Arctium lappa (AL) (Burdock) has been used for centuries to treat a variety of ailments. Extracts of burdock root (BR) are found in a variety of herbal preparations, as well as homeopathic remedies. Arctium has been used as medicine and health supplement for hundreds of years in Europe, North America, and Asia. It is popular as a medicinal plant in traditional Chinese medicine where it is extensively used for various ailments. In recent years, immense phytochemical and pharmacological screening of Arctium has shown tremendous activity against various diseases. The plant has shown biological activity as anti-inflammatory, antiallergic, antidiabetic, antineoplastic, antimutagenic, antiviral, urolytic, antitoxic, antileukemic, hepatoprotective, growth stimulating, mild laxative, mild diuretic, depurative, diaphoretic, antibacterial, antirheumatic, and antipyretic agent. The present review highlights botanical description, distribution, chemical constituents, and the pharmacological effects of AL. The aim of this review is to correlate active principles of the plant to their pharmacological activity and thus explore the potential of AL as a source of therapeutic agents.

Keywords: Arctium lappa (burdock),, Medicine,, Pharmacology.


1. Lim TK. Modified stems, roots, bulbs. In: Edible Medicinal and Non Medicinal Plants. Vol. 9. Netherlands: Springer; 2015.
2. Nasir E, Ali SI, editors. Flora of Pakistan. Karachi, Islamabad: Fakhri Printing Press; 1970.
3. Kim YK, Koppula S, Shim DW, In EJ, Kwak SB, Kim MK, et al. Inhibitory effect and mechanism of Arctium lappa extract on NLRP3 inflammasome activation. Evid Based Complement Alternat Med 2018;2018:6346734.
4. Shi H, Dong G, Yan F, Zhang H, Li C, Ma Q, et al. Arctigenin ameliorates inflammation by regulating accumulation and functional activity of MDSCs in endotoxin shock. Inflammation 2018;41:2090 100.
5. Song HS, Koo HJ, Park BK, Kwon JE, Jang SA, Baek HJ, et al. The suppressive effect of the three-herb extract mixture on vascular and liver inflammation in atherogenic diet with high fructose-fed mice. Pharm Biol 2018;56:32-42.
6. Carlotto J, de Souza LM, Baggio CH, Werner MF, Maria-Ferreira D, Sassaki GL, et al. Polysaccharides from Arctium lappa L.: Chemical structure and biological activity. Int J Biol Macromol 2016;91:954-60.
7. Yang YN, Huang XY, Feng ZM, Jiang JS, Zhang PC. New butyrolactone type lignans from arctiifructus and their anti-inflammatory activities. J Agric Food Chem 2015;63:7958-66.
8. Pomari E, Stefanon B, Colitti M. Effect of plant extracts on H2O2-induced inflammatory gene expression in macrophages. J Inflamm Res 2014;7:103-12.
9. Wu X, Dou Y, Yang Y, Bian D, Luo J, Tong B, et al. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of th1 and th17 cells via an mTORC1-dependent pathway. Biochem Pharmacol 2015;96:323-36.
10. Maghsoumi-Norouzabad L, Alipoor B, Abed R, Eftekhar Sadat B, Mesgari-Abbasi M, Asghari Jafarabadi M, et al. Effects of Arctium lappa L. (Burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis. Int J Rheum Dis 2016;19:255-61.
11. Lin CC, Lu JM, Yang JJ, Chuang SC, Ujiie T. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med 1996;24:127 37.
12. Lee JH, Kim C, Lee J, Um JY, Sethi G, Ahn KS, et al. Arctiin is a pharmacological inhibitor of STAT3 phosphorylation at tyrosine 705 residue and potentiates bortezomib-induced apoptotic and anti-angiogenic effects in human multiple myeloma cells. Phytomedicine 2019;55:282-92.
13. Ke N, Liu Q, Pi L, Fang J, Chen L, Chen X, et al. The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged1. Mol Med Rep 2019;19:3642-8.
14. Lin CY, Hsieh PL, Liao YW, Peng CY, Yu CC, Lu MY, et al. Arctigenin reduces myofibroblast activities in oral submucous fibrosis by LINC00974 inhibition. Int J Mol Sci 2019;20:E1328.
15. Gurunanselage Don RA, Yap MK. Arctium lappa L. Root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in jurkat human leukemic T cells. Biomed Pharmacother 2019;110:918-29.
16. He Y, Fan Q, Cai T, Huang W, Xie X, Wen Y, et al. Molecular mechanisms of the action of arctigenin in cancer. Biomed Pharmacother 2018;108:403-7.
17. Fujioka R, Mochizuki N, Ikeda M, Sato A, Nomura S, Owada S, et al. Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer. PLoS One 2018;13:e0198219.
18. Sun Y, Tan YJ, Lu ZZ, Li BB, Sun CH, Li T, et al. Arctigenin inhibits liver cancer tumorigenesis by inhibiting gankyrin expression via C/EBP? and PPAR?. Front Pharmacol 2018;9:268.
19. Lee YJ, Oh JE, Lee SH. Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells through ROS-mediated mitochondrial damage and the inhibition of PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun 2018;505:1244-50.
20. Moritani S, Nomura M, Takeda Y, Miyamoto K. Cytotoxic components of bardanae fructus (goboshi). Biol Pharm Bull 1996;19:1515-7.
21. Susanti S, Iwasaki H, Itokazu Y, Nago M, Taira N, Saitoh S, et al. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L. J Nat Med 2012;66:614-21.
22. Tezuka Y, Yamamoto K, Awale S, Lia F, Yomoda S, Kadota S, et al. Anti-austeric activity of phenolic constituents of seeds of Arctium lappa. Nat Prod Commun 2013;8:463-6.
23. Sun Q, Liu K, Shen X, Jin W, Jiang L, Sheikh MS, et al. Lappaol F, a novel anticancer agent isolated from plant Arctium lappa L. Mol Cancer Ther 2014;13:49-59.
24. Su S, Cheng X, Wink M. Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells. Phytomedicine 2015;22:301-7.
25. Predes FS, Ruiz AL, Carvalho JE, Foglio MA, Dolder H. Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts. BMC Complement Altern Med 2011;11:25.
26. Fatemeh K, Khosro P, Talebi AF. Antiproliferative activity of aqueous extract from Arictum lappa L. root in human erythroleukemia cell line (k562) and lymphocyte cell. Life Sci J 2013;10:656-61.
27. Umehara K, Nakamura M, Miyase T, Kuroyanagi M, Ueno A. Studies on differentiation inducers. VI. Lignan derivatives from arctium fructus. (2). Chem Pharm Bull (Tokyo) 1996;44:2300-4.
28. Hirano T, Homma M, Oka K. Effects of stinging nettle root extracts and their steroidal components on the na+,K(+)-ATPase of the benign prostatic hyperplasia. Planta Med 1994;60:30-3.
29. Morita K, Kada T, Namiki M. A desmutagenic factor isolated from burdock (Arctium lappa Linne). Mutat Res 1984;129:25-31.
30. Ito Y, Maeda S, Sugiyama T. Suppression of 7,12-dimethylbenz[a] anthracene-induced chromosome aberrations in rat bone marrow cells by vegetable juices. Mutat Res 1986;172:55-60.
31. Di Giorgio C, Boyer L, De Meo M, Laurant C, Elias R, Ollivier E, et al. In vitro and in vivo antimutagenic effects of DIG, a herbal preparation of Berberis vulgaris, Taraxacum officinale and Arctium lappa, against mitomycin C. J Nat Med 2015;69:267-77.
32. Chen J, Li W, Jin E, He Q, Yan W, Yang H, et al. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus Type 2. Res Vet Sci 2016;106:159-64.
33. Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med 1998;64:97-109.
34. Eich E, Pertz H, Kaloga M, Schulz J, Fesen MR, Mazumder A, et al. (-)-arctigenin as a lead structure for inhibitors of human immunodeficiency virus Type-1 integrase. J Med Chem 1996;39:86-95.
35. Schröder HC, Merz H, Steffen R, Müller WE, Sarin PS, Trumm S, et al. Differential in vitro anti-HIV activity of natural lignans. Z Naturforsch C 1990;45:1215-21.
36. Yen CH, Chiu HF, Huang SY, Lu YY, Han YC, Shen YC, et al. Beneficial effect of burdock complex on asymptomatic Helicobacter pylori-infected subjects: A randomized, double-blind placebo-controlled clinical trial. Helicobacter 2018;23:e12469.
37. Habibipour R, Rajabi M. Antibacterial effects of Arctium lappa and Artemesia absinthium extracts in laboratory conditions. J Herb Med Pharmacol 2015;4:133-7.
38. Rajasekharan SK, Ramesh S, Bakkiyaraj D, Elangomathavan R, Kamalanathan C. Burdock root extracts limit quorum-sensing-controlled phenotypes and biofilm architecture in major urinary tract pathogens. Urolithiasis 2015;43:29-40.
39. Wei G, Liang T, Wei C, Nong X, Lu Q, Zhao J, et al. Arctigenin inhibits RANKL-induced osteoclastogenesis and hydroxyapatite resorption in vitro and prevents titanium particle-induced bone loss in vivo. J Cell Biochem 2019;120:5367-76.
40. Vengerovskii AI, Yakimova TV, Nasanova ON. Influence of medicinal plant extracts on the functions and antioxidant protection of erythrocytes in rats with experimental diabetes mellitus. Eksp Klin Farmakol 2016;79:29-33.
41. Cao J, Li C, Zhang P, Cao X, Huang T, Bai Y, et al. Antidiabetic effect of burdock (Arctium lappa L.) root ethanolic extract on streptozotocin-induced diabetic rats. Afr J Biotechnol 2012;11:9079-85.
42. Wang X, Jia W, Zhao A, Wang X. Anti-influenza agents from plants and traditional Chinese medicine. Phytother Res 2006;20:335-41.
43. Cheng X, Wang H, Yang J, Cheng Y, Wang D, Yang F, et al. Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice. Biomed Pharmacother 2018;102:464-71.
44. Chen KY, Lin JA, Yao HY, Hsu AC, Tai YT, Chen JT, et al. Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways. Nutr Res 2018;52:87-97.
45. Gao Y, Gu C, Wang K, Wang H, Ruan K, Xu Z, et al. The effects of hypoglycemia and weight loss of total lignans from fructus arctii in KKAy mice and its mechanisms of the activity. Phytother Res 2018;32:631-42.
46. El-Kott AF, Bin-Meferij MM. Use of Arctium lappa extract against acetaminophen-induced hepatotoxicity in rats. Biochem Biophys Res Commun 2015;468:837-42.
47. Kato T, Hirose M, Takahashi S, Hasegawa R, Kohno T, Nishibe S, et al. Effects of the lignan, arctiin, on 17-beta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats. Anticancer Res 1998;18:1053-7.
48. Predes FS, da Matta SL, Monteiro JC, de Oliveira TT. Investigation of liver tissue and biochemical parameters of adult Wistar rats treated with Arctium lappa L. Braz Arch Biol Technol 2009;52:335-40.
49. Jiang YY, Yu J, Li YB, Wang L, Hu L, Zhang L, et al. Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L. Int J Biol Macromol 2019;123:531-8.
50. Yari S, Karamian R, Asadbegy M, Hoseini E, Moazzami Farida SH. The protective effects of Arctium lappa L. Extract on testicular injuries induced by ethanol in rats. Andrologia 2018;50:e13086.
51. Kwon YK, Choi SJ, Kim CR, Kim JK, Kim YJ, Choi JH, et al. Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in A?1-42-induced mouse model. Appl Biol Chem 2016;59:553 65.
52. He J, Huang XY, Yang YN, Feng ZM, Jiang JS, Zhang PC, et al. Two new compounds from the fruits of Arctium lappa. J Asian Nat Prod Res 2016;18:423-8.
53. Peng-Cheng L, Shu-Qing H. Antioxidant effects of Arctium lappa L. BMC Complement Altern Med 2016;16:6.
54. Liu W, Wang J, Zhang Z, Xu J, Xie Z, Slavin M, et al. In vitro and in vivo antioxidant activity of a fructan from the roots of Arctium lappa L. Int J Biol Macromol 2014;65:446-53.
55. Chen L, Liu DN, Wang Y, Liu XY, Han S, Zhang K, et al. Treatment with MQA, a derivative of caffeoylquinic acid, provides neuroprotective effects against cerebral ischemia through suppression of the p38 pathway and oxidative stress in rats. J Mol Neurosci 2019;67:604-12.
56. Tian X, Gao L, An L, Jiang X, Bai J, Huang J, et al. Pretreatment of MQA, a caffeoylquinic acid derivative compound, protects against H2O2 -induced oxidative stress in SH-SY5Y cells. Neurol Res 2016;38:1079-87.
57. JianFeng C, PengYing Z, ChengWei X, TaoTao H, YunGui B, KaoShan C, et al. Effect of aqueous extract of Arctium lappa L. (burdock) roots on the sexual behavior of male rats. BMC Complement Altern Med 2012;12:8.
58. Ahangarpour A, Oroojan AA, Heidari H, Ghaedi E, Taherkhani R. Effects of hydro-alcoholic extract from Arctium lappa L. (Burdock) root on gonadotropins, testosterone, and sperm count and viability in male mice with nicotinamide/streptozotocin-induced Type 2 diabetes. Malays J Med Sci 2015;22:25-32.
59. Alwan HD, Hasan HF. A comparative study between the effects of Arctium lappa L. leaves extract and pentoxifylline on fertility of male rats treated with gentamicin. Int J Adv Biol Res 2015;5:293-8.
60. Du Y, Li W, Li Y, Yang J, Wang X, Yin S, et al. Repeated arctigenin treatment produces antidepressant-and anxiolytic-like effects in mice. Brain Res Bull 2019;146:79-86.
61. da Silva LM, Allemand A, Mendes DA, Dos Santos AC, André E, de Souza LM, et al. Ethanolic extract of roots from Arctium lappa L. Accelerates the healing of acetic acid-induced gastric ulcer in rats: Involvement of the antioxidant system. Food Chem Toxicol 2013;51:179 87.
62. de Almeida BA, Luiz-Ferreira A, Cola M, Batista LM, Di Pietro Magri L, Tiene MR, et al. Antiulcerogenic activity of aqueous fraction from leaves of Arctium lappa L. (Asteraceae). J Med Plants Res 2012;6:1764 9.
63. Wang Y, Zhang N, Kan J, Zhang X, Wu X, Sun R, et al. Structural characterization of water-soluble polysaccharide from Arctium lappa and its effects on colitis mice. Carbohydr Polym 2019;213:89-99.
64. Wu X, Yang Y, Dou Y, Ye J, Bian D, Wei Z, et al. Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. Fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice. Int Immunopharmacol 2014;23:505-15.
65. Yoo JM, Park KI, Yang JH, Cho WK, Lee B, Ma JY, et al. Anti-allergic actions of F-PASA, a novel herbal cocktail, in igE/antigen-mediated allergic responses in RBL-2H3 cells and passive cutaneous anaphylaxis in mice. Phytomedicine 2019;55:229-37.
66. Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, et al. Anti-allergic and anti-inflammatory effects of butanol extract from Arctium lappa L. Clin Mol Allergy 2011;9:4.
67. Yoo JM, Yang JH, Yang HJ, Cho WK, Ma JY. Inhibitory effect of fermented Arctium lappa fruit extract on the igE-mediated allergic response in RBL2H3 cells. Int J Mol Med 2016;37:501-8.
68. Yang WS, Lee SR, Jeong YJ, Park DW, Cho YM, Joo HM, et al. Antiallergic activity of ethanol extracts of Arctium lappa L. Undried roots and its active compound, oleamide, in regulating fc?RI-mediated and MAPK signaling in RBL-2H3 cells. J Agric Food Chem 2016;64:3564-73.
69. Corrêa RC, Peralta RM, Haminiuk CW, Maciel GM, Bracht A, Ferreira IC, et al. New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges. Crit Rev Food Sci Nutr 2018;58:942-57.
70. Lu Z, Chang L, Du Q, Huang Y, Zhang X, Wu X, et al. Arctigenin induces an activation response in porcine alveolar macrophage through TLR6-NOX2-MAPKs signaling pathway. Front Pharmacol 2018;9:475.
71. Baraya YS, Wong KK, Yaacob NS. The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: A review. Anticancer Agents Med Chem 2017;17:770-83.
72. Shareef M, Ashraf MA, Sarfraz M. Natural cures for breast cancer treatment. Saudi Pharm J 2016;24:233-40.
73. Li W, Zhang Z, Zhang K, Xue Z, Li Y, Zhang Z, et al. Arctigenin suppress th17 cells and ameliorates experimental autoimmune encephalomyelitis through AMPK and PPAR-?/ROR-?t signaling. Mol Neurobiol 2016;53:5356-66.
74. Wang Z, Li P, Wang C, Jiang Q, Zhang L, Cao Y, et al. Protective effects of Arctium lappa L. Root extracts (AREs) on high fat diet induced quail atherosclerosis. BMC Complement Altern Med 2016;16:6.
75. Liu Y, Wang G, Yang M, Chen H, Zhao Y, Yang S, et al. Arctigenin reduces blood pressure by modulation of nitric oxide synthase and NADPH oxidase expression in spontaneously hypertensive rats. Curr Ther Res Clin Exp 2015;77:73-8.
76. Chang CZ, Wu SC, Chang CM, Lin CL, Kwan AL. Arctigenin, a potent ingredient of Arctium lappa L. induces endothelial nitric oxide synthase and attenuates subarachnoid hemorrhage-induced vasospasm through PI3K/Akt pathway in a rat model. Biomed Res Int 2015;2015:490209.
77. Lee YJ, Choi DH, Cho GH, Kim JS, Kang DG, Lee HS, et al. Arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/ cholesterol diets. BMC Complement Altern Med 2012;12:116.
78. Zhang J, Cao P, Gui J, Wang X, Han J, Wang Y, et al. Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice. Life Sci 2019;223:194-201.
79. Ma ST, Liu DL, Deng JJ, Niu R, Liu RB. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res 2013;27:1474-80.
80. Li K, Zhu L, Li H, Zhu Y, Pan C, Gao X, et al. Structural characterization and rheological properties of a pectin with anti-constipation activity from the roots of Arctium lappa L. Carbohydr Polym 2019;215:119-29.
81. Grases F, Melero G, Costa-Bauzá A, Prieto R, March JG. Urolithiasis and phytotherapy. Int Urol Nephrol 1994;26:507-11.
82. Takeda H, Kiriyama S. Correlation between the physical properties of dietary fibers and their protective activity against amaranth toxicity in rats. J Nutr 1979;109:388-96.
83. Takeda H, Kiriyama S. Effect of feeding amaranth (food red no 2) on the jejunal sucrase and digestion-absorption capacity of the jejunum in rats. J Nutr Sci Vitaminol (Tokyo) 1991;37:611-23.
84. Kimura T, Iida K, Takei Y. Mechanisms of adverse effect of air-oxidized soy bean oil-feeding in rats. J Nutr Sci Vitaminol (Tokyo) 1984;30:125 33.
85. Morita T, Ebihara K, Kiriyama S. Dietary fiber and fat-derivatives prevent mineral oil toxicity in rats by the same mechanism. J Nutr 1993;123:1575-85.
86. Mounica PS, Babu MR, Saraswathi DD, Vajja S, Swetha B, Gandhi B. Antimicrobial efficacy of herbs in endodontics. J Adv Oral Res 2015;6:44-7.
87. Dodov MG, Kulevanova S. A review of phytotherapy of acne vulgaris. Maced Pharm Bull 2009;55:3-22.
88. Zhao J, Evangelopoulos D, Bhakta S, Gray AI, Seidel V. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. J Ethnopharmacol 2014;155:796-800.
89. Saraswathy GR, Sathiya R, Anbu J, Maheswari E. Antitussive medicinal herbs-an update review. Int J Pharm Sci Drug Res 2014;6:12-9.
90. Rodriguez P, Blanco J, Juste S, Garcés M, Pérez R, Alonso L, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
91. Rhoads PM, Tong TG, Banner W Jr., Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984;22:581-4.
92. Goodwin RA Jr. Burdock ophthalmia. J Maine Med Assoc 1968;59:53 4.
93. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: Lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8.
94. Sharma RK, Goyal AK. Agro-pesticides and andrology. Int J Pharm Pharm Sci 2014;6:12-9.
95. Arya A, Sharma GD. Combined effects of cadmium and mecury on some biochemical and histochemical changes in liver, kidney and gills of Channa punctatus (bloch). Int J Pharm Pharm Sci 2015;8:117-20.
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GOWHER GUNA. “THERAPEUTIC VALUE OF ARCTIUM LAPPA LINN. – A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, May 2019, pp. 53-59,
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