AN AN OBSERVATIONAL STUDY OF PRESCRIPTION PATTERN OF DRUGS FOR OSTEOARTHRITIS IN A NORTH INDIAN MEDICAL COLLEGE
Objective: The objective of the study is to analyze the prescription pattern of drugs for osteoarthritis (OA) in a north Indian medical college collaborated with a tertiary care hospital.
Methods: An observational study was conducted on 300 patients diagnosed with OA in the department of orthopedics in collaboration with the department of pharmacology, and thus, prescription was collected as in a cross-sectional manner for 6 months and the same were analyzed in the Department of Orthopedics in tertiary care hospital collaborated with medical college.
Results: The average age of patients participating in this present study was 56.46±7.4 years with affected age group of 46-60 years. 60 % of females were affected by osteoarthritis outnumbering male (40 %) patients in this present study. The most commonly involved joint was knee joint (87.33 %) in patients diagnosed with osteoarthritis followed by back (6.67 %) and hip joint (6%). The combination therapy (90 %) outweighed monotherapy (10 %) with preferred route of drug administration as oral route (90 %) followed by topical route (10 %). The average number of drugs prescribed for patients of osteoarthritis was 2.62±0.76. This present study concludes that NSAIDs (45.8%) were prescribed most commonly. However, the drug paracetamol was lesser prescribed and other drugs such as Diclofenac (27.22 %) and acetaminophen (34.44 %) most of all followed by Nimesulide (16.67 %), ibuprofen (13.33 %) and Rofecoxib/valdecoxib (8.33 %) were prescribed.
Conclusion: This present study concludes that NSAIDs were most commonly prescribed as p-drugs while paracetamol was undermined prescribed.
2. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008;58:26-35.
3. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646-56.
4. Brooks PM. Impact of osteoarthritis on individuals and society: How much disability? Social consequences and health economic implications. Curr Opin Rheumatol 2002;14:573-7.
5. David JH, Victoria LJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 2014;28:5-15.
6. Ahmed M, Ali N, Rahman UZ, Misbahullah K. A study on prescribing patterns in the management of arthritis in the department of orthopaedics. Sch Res Libr 2012;4:5-27.
7. Alacqua M, Trifirò G, Cavagna L, Caporali R, Montecucco CM, Moretti S, et al. Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: The effect of rofecoxib withdrawal. Arthritis Rheum 2008;59:568-74.
8. Ullal SD, Narendranath S. Prescribing pattern for osteoarthritis in a tertiary care hospital. J Clin Diagn Res 2010;4:2421-6.
9. Jadhav MP, Dominic JC, Mukte AP. A prospective observational study to assess quality of life and prescription pattern in osteoarthritis patients at a tertiary care health center in Mumbai. Indian J Med Sci 2011;65:58 63.
10. Kulkarni SK, Bishnoi M, Kumar A. Prescription monitoring of management pattern of osteoarthritis with non-steroidal anti-inflammatory drugs at PUHC, Chandigarh in India. Indian J Pharm Sci 2006;68:525-7.
11. Rahman A. Prescription pattern of drugs for osteoarthritis in a tertiary care hospital. IOSR J Dent Med Sci 2018;17:36-9.
12. Gurung S, Babu S, Sabu S, Shibu RM, Begum R, Nanjwade BK. A study on prescribing patterns in the management of osteoarthritis and rheumatoid arthritis in the department of orthopedics. World J Pharm Pharm Sci 2016;5:1472-93.
13. Gupta M, Malhotra S. pattern of prescription of non-steroidal anti-inflammatory drugs in the orthopaedic outpatient clinic of a North Indian tertiary care hospital. Indian J Pharm 2005;37:404-5.
14. Richard CM, Bars ML, Schimdely N, Dougados M. Paracetamol in osteoarthritis of the knee. Ann Rheum Dis 2004;63:923-30.
15. Nhac-Vu HT, Ngoc-Van TT, Kim-Tuyen NT. Describing the list of drugs of district 7 hospitals in 2014. J Pract Med 2016;61:21-3.
16. Nhu H, Tuyen CT, Nhac Vu HT. Characteristics of the modern medicines list used at Phu Nhuan hospital in 2012-2017. Int J Pharm Pharm Sci 2017;11:27-30.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.