DEVELOPMENT OF UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF IMATINIB MESYLATE (ITM) IN BULK AND FORMULATION

Authors

  • PATIL SMITA J. Asst. Professor, Shree Santkrupa College of Pharmacy, Ghogaon.
  • DOIJAD RAJENDRA C.
  • DHUMAL PRIYA P.

Abstract

A simple and precise spectroscopic method for determination of Imatinib Mesylate in its bulk and tablet dosage forms has been developed and validated. This method  based upon measurement of light absorption in UV region. The UV spectra of Imatinib Mesylate showed that maximum absorbance of light was observed at 281 nm and linearity was observed in the concentration range of 2-28ug/ml with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.040468 (μg/ml) and 0.122263 (μg/ml) respectively by simple UV Spectroscopy.

Author Biography

PATIL SMITA J., Asst. Professor, Shree Santkrupa College of Pharmacy, Ghogaon.

Pharmaceutical Chemistry Department

References

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Published

2013-07-01

How to Cite

SMITA J., P., D. RAJENDRA C., and D. PRIYA P. “DEVELOPMENT OF UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF IMATINIB MESYLATE (ITM) IN BULK AND FORMULATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 3, July 2013, pp. 54-57, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34.

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