SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL THIAZOLE-PYRAZOLE INTEGRATED CHALCONES AS ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS

  • DNYANESHWAR SIRSAT Department of Chemistry, Anandibai Raorane Arts, Commerce, and Science College, Vaibhavwadi, Sindhudurg, Maharashtra, India.
  • PRADEEP KATE Department of Chemistry, Karmaveer Bhaurao Patil Mahavidyalaya, Pandharpur, Solapur, Maharashtra, India.
  • MADHUSUDAN BACHUTE Department of Chemistry, Sangola College, Sangola, Solapur, Maharashtra, India.

Abstract

Objective: The objective of the present study was to synthesize the thiazole-pyrazole integrated chalcones and their in vitro antioxidant and anti- inflammatory evaluation.


Methods: The designed hybrid thiazole-pyrazole integrated chalcones (3a-j) were synthesized by Claisen–Schmidt reaction of substituted 1-(4-methyl-2-phenylthiazol-5-yl) ethanone and substituted pyrazole aldehyde in the presence of 10% NaOH in ethanol solvent under reflux condition. The chemical structures of synthesized compounds were confirmed by IR, 1H nuclear magnetic resonance (NMR), 13C NMR, and high- resolution mass spectra.


Results: All the title compounds were screened for their in vitro antioxidant and anti-inflammatory activity. The screening data indicated that tested compounds showed potent antioxidant activity with moderate anti-inflammatory potential.


Conclusion: Antioxidant screening data reveal that most of the synthesized compounds possess excellent 1,1-diphenyl-2-picrylhydrazyl and NO radical scavenging activity. Most of the compounds found to possess marked anti-inflammatory potential by effectively inhibiting the heat-induced albumin denaturation.

Keywords: Thiazole,, Pyrazole,, Chalcone,, Antioxidant activity,, Anti-inflammatory activity.

References

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DNYANESHWAR SIRSAT, PRADEEP KATE, and MADHUSUDAN BACHUTE. “SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL THIAZOLE-PYRAZOLE INTEGRATED CHALCONES AS ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, June 2019, pp. 311-5, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34143.
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