ANTIDIABETIC, ANTI-INFLAMMATORY, ANTIBACTERIAL, ANTI-HELMINTHIC, ANTIOXIDANT AND NUTRITIONAL POTENTIAL OF MUSA PARADISIACA

  • OLUWAFEMI OMONIYI OGUNTIBEJU Department of Biomedical Sciences, Phytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa.

Abstract

The medicinal and economic values of medicinal plants remain vital to the well-being, growth, and development of humans, especially those living in developing countries. It has been shown that due to the availability, less side effects, general acceptance by local people, medicinal plants contribute significantly to improving health-care delivery system by supplying important pharmaceutical and pharmacological ingredients that are affordable to the teaming majority of people. It is estimated that 30% of pharmaceutical products that are sold globally is rich in compounds derived from plant materials. It is also of interest to report that over 80% of the people in developing countries, mostly in Asia and Africa depend heavily on plant products in the treatment and management of various disease conditions. The interest in demand and utilization of medicinal plants has also increased significantly due to the high cost of orthodox medications, lack of good transportation, lack of storage facilities, inadequate availability of health professionals, and lack of the will and political power to provide basic health needs for the citizens of these developing countries. Musa paradisiaca is one of such medicinal plants believed to have multi-faceted health benefits and its health benefits extend to different countries of the world. It is a stable crop found in Asia, Africa, and Central and South America commonly consumed as energy-yielding food but with many medicinal values as well. It is used in the treatment and management of diabetes mellitus, inflammation, parasitic infection, microbial infections, renal, and liver dysfunction. This manuscript focuses on the antidiabetic, antioxidant, anti-inflammatory, antimicrobial, anti-helminthic, and nutritional values of M. paradisiaca.

Keywords: Diabetes mellitus, Inflammation, Microbial infection, Parasitic infection, Management, Diseases, Nutrition

References

1. Aslam MS, Ahmad MS. Worldwide importance of medicinal plants: Current and historical perspective. Recent Adv Biol Med 2016;2:88-93.
2. Bukar BB, Dayom DW, Uguru MO. The growing economic importance of medicinal plants and the need for developing countries to harness from it: A mini review. IOSR J Pharm 2016;6:42-52.
3. Oguntibeju OO, Meyer S, Aboua YG, Goboza M. Hypoxis hemerocallidea significantly reduced hyperglycaemia and hyperglycaemic-induced oxidative stress in the liver and kidney tissues of streptozotocin-induced diabetic male Wistar rats. Evid Based Complement Altern Med 2016;2016:1-10.
4. Chen HZ. Current status of blood lipid level and treatment of hyperglycaemia in Chinese population. J Chin Integr Med 2004;2:81-2.
5. Mishra PR, Panda PK, Apanna KC, Panigrahi S. Evaluation of acute hypolipidaemic activity of different plant extracts in triton WR- 1339-induced hyperlipidaemia in albino rats. Pharmacol Online 2011;3:319-23.
6. Dawit A. Traditional medicine in Ethiopia: The attempt being made to promote it for effective and better utilization. Ethiopia J Sci 1986;9:6269.
7. World Health Organization. Legal Status of Traditional Medicine and Complementary Alternative Medicine: A World-Wide Review. Geneva, Switzerland: World Health Organization; 2001.
8. Zemede A. Ethno-Botany of Nation, Nationalities and Peoples in Gambella, Benishangul-Gumuz and Southern region of Ethiopia. Addis Ababa: Addis Ababa University; 1999. p. 172.
9. Knobel DL, Cleaveland S, Coleman PG, Fèvre EM, Meltzer MI, Miranda ME, et al. Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ 2005;83:360-8.
10. World Health Organization. WHO Expert Consultation on Rabies. WHO Technical Report Series, 931. Geneva, Switzerland: World Health Organization; 2005. p. 1-12.
11. Imam MA, Akter S. Musa paradisiaca L. and Musa sapientum L.: A phytochemical and pharmacological review. J Appl Pharm Sci 2011;1:14-20.
12. Ighodaro OM. Evaluation study on Nigerian species of Musa paradisiaca peels: Phytochemical screening, proximate analysis, mineral composition and antimicrobial activities. Researcher 2012;4:17-20.
13. Ibegbu AO, Okonji UJ, Hammah WO, Umana UE, Iyembe DT, Musa SA. Anti-inflammatory effects of the aqueous extracts of plantain roots (Musa species). Br J Pharm Toxicol 2012;3:70-5.
14. Nelson SC, Ploetz RC, Kepler AK. Musa Species (Banana and Plantain) Profiles for Pacific Island Agroforestry; 2006. http://www.agroforestry. net.
15. Vandana I, Gupta AK, Mukerjee A. Phyochemical screening and evaluation of anti-inflammatory activity of aerial part extracts of Plantago major L. Asian J Pharm Clin Res 2017;10:307-11.
16. Okoli RI, Aigbe O, Ohaju-Obodo JO, Mensah JK. Medicinal herbs used for managing some common ailments among Esan people of Edo State, Nigeria. Pak J Nutr 2007;6:490-6.
17. Partha P, Hossain AB. Ethnobotanical investigation into the Mandi ethnic community in Bangladesh. Bangladesh J Plant Taxon 2007;14:129-45.
18. Khare CP. Indian Medicinal Plants. New York, USA: Springer Science; 2007. p. 426.
19. Rai PK, Jaiswal D, Rai NK, Pandhija S, Rai AK, Watal G, et al. Role of glycemic elements of Cynodon dactylon and Musa paradisiaca in diabetes management. Lasers Med Sci 2009;24:761-8.
20. Beara IN, Lesjak MM, Jovin ED, Balog KJ, Anackov GT, Orci? DZ, et al. Plantain (Plantago L.) species as novel sources of flavonoid antioxidants. J Agric Food Chem 2009;57:9268-73.
21. Jamilah J, Sharifa R, Sharifah AA. GC-MS analysis of various extracts from leaf of Plantago major used as traditional medicine. World Appl Sci J 2012;17:67-70.
22. Ploetz RC, Kepler AK, Daniels J, Nelson SC. Banana and plantain-an overview with emphasis on Pacific Island cultivars. Agro For Vet 2007;1:1-27.
23. Virginia DK, Luisa HC, Danielle FP, Barbara GP, Femanda AM, Ziliani S, et al. Beneficial effects of banana leaves (Musa paradisiaca) on glucose homeostasis: Multiple sites of action. Rev Bras Phramacogn 2013;23:706-15.
24. Lakshmi SK, Agarwal SK, Ansari AJ, Mahdi AA, Srivastava AK. Antidiabetic potential of Musa paradisiaca in streptozotocin-induced diabetic rats. J Phytopharmacol 2014;3:77-81.
25. Pari L, Umamaheswari J. Antihyperglycaemic activity of Musa sapientum flowers: Effect on lipid peroxidation in alloxan diabetic rats. Phytother Res 2000;14:136-8.
26. Ojewole JA, Adewunmi CO. Hypoglycemic effect of methanolic extract of Musa paradisiaca (Musaceae) green fruits in normal and diabetic mice. Methods Find Exp Clin Pharmacol 2003;25:453-6.
27. Mohan Kumar M, Joshi MC, Prabha T, Dorababu M, Goel RK. Effect of plantain banana on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals. Indian J Exp Biol 2006;44:292-9.
28. Shanmuga SC, Subramanian S. Biochemical evaluation of hypoglycaemic activity of Musa Paradisiaca flowers in STZ-induced experimental diabetes in rats. Asian J Res Chem 2011;4:827-33.
29. Iroaganachi M, Eleazu C, Okafor P. Effect of unripe plantain (Musa paradisiaca) and ginger (Zingiber officinale) on renal dysfunction in streptozotocin-induced diabetic rats. JOP 2015;16:167-70.
30. Eleazu CO, Okafor P. Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats. Interv Med Appl Sci 2015;7:9-16.
31. Famakin O, Fatoyinbo A, Ijarotimi OS, Badejo AA, Fagbemi TN. Assessment of nutritional quality, glycaemic index, antidiabetic and sensory properties of plantain (Musa paradisiaca)-based functional dough meals. J Food Sci Technol 2016;53:3865-75.
32. Franklin PX, Pillai AD, Rathod PD, Yerande S, Nivsarkar M, Padh H, et al. 2-amino-5-thiazolyl motif: A novel scaffold for designing anti-inflammatory agents of diverse structures. Eur J Med Chem 2008;43:129-34.
33. Ahlborn H, Henderson S, Davies N. No immediate pain relief for the pharmaceutical industry. Curr Opin Drug Discov Devel 2005;8:384-91.
34. Adelolu AT, Enesi DO. Assessment of proximate, mineral, vitamin and phytochemical composition of plantain (Musa paradisiaca) bract-an agricultural waste. Int Res J Plant Sci 2013;4:192-7.
35. Bindu HM, Guddeti V, Praveen TK, Surekha LS, Gayathri M, Allam PV, et al. Evaluation of anti-inflammatory activity of Musa paradisiac (Linn) leaves extract in rats. Int Pharm Chem Biol Sci 2014;4:753-7.
36. Rao US, Ahmad BA, Mohd KS. In vitro oxide scavenging and anti-inflammatory activities of different solvent extracts of various parts of Musa paradisiaca. Malays J Anal Sci 2016;20:1191-202.
37. Saraswathi RS, Malathi M. In vitro anti-inflammatory activity of different variety of Musa sapientum (banana) peel extract. Int J Curr Res 2017;9:47300-2.
38. Biswas C, Basak D, Chakroverty R, Banerjee A, Dey S, Mazumder UK. Effect of methanol extract of Musa paradisiaca (Linn) stem juice on chemically induced acute inflammation. Int J Pharm Pharm Sci 2012;4:148-50.
39. Karadi RV, Shah A, Parekh P, Azmi P. Antimicrobial activities of Musa paradisiaca and Cocas nucifera. Int Res Pharm Biomed Sci 2011;2:264-7.
40. de Melo Júnior EJ, Raposo MJ, Lisboa Neto JA, Diniz MF, Marcelino Júnior CA, Sant’Ana AE, et al. Medicinal plants in the healing of dry socket in rats: Microbiological and microscopic analysis. Phytomedicine 2002;9:109-16.
41. Padam BS, Tin HS, Chye FY, Abdullah MI. Anti-bacterial and antioxidant activities of the various solvent extracts of Musa paradisiaca inflorescences. J Biol Sci 2012;12:62-73.
42. Matthew M, Obbard J. Optimisation of the dehydrogenase assay for measurement of indigenous microbial activity in beach sediments contaminated with petroleum. Biotech Lett 2001;23:227-30.
43. Alisi CS, Nwanyanwu CE, Akujobi CO, Ibegbulem CO. Inhibition of dehydrogenase activity in pathogenic bacteria isolates by aqueous extracts of Musa paradisaca. Afr J Biotech 2008;7:1821-5.
44. Akhtar MS, Zafar I, Khan MN, Muhammad L. Antihelminthic activity of medicinal plants with particular reference to their use in animals in Indo-Pakistan subcontinent. Small Rumin Res 2000;38:99-107.
45. Tambe VD, Nirmal SA, Jadhav RS, Ghogare PB, Bhalke RD. Antihelmintic activity of Wedelia trilobata leaves. Ind J Nat Prod 2006;22:27-9.
46. Krishna VV, Kumar KG, Pradeepa K, Kumar SR, Vilay K. Antihelminthic activity of Musa paradisiaca (Linn) cv Puttabale. Int J Pharm Sci Drug Res 2013;5:67-9.
47. Hussain A, Khan MN, Sajid Z, Iqbal MK, Khan RZ, Abbas MA. In vitro screening of the leaves of Musa paradisiaca for anti-helmintic activity. J Anim Plant Sci 2010;20:5-8.
48. Kolodziej H, Kiderlen AF. Antileishmanial activity and immune modulatory effects of tannins and related compounds on Leishmania parasitised RAW 264.7 cells. Phytochemistry 2005;66:2056-71.
49. Accioly MP, Bevilaqua CM, Rondon FC, de Morais SM, Machado LK, Almeida CA, et al. Leishmanicidal activity in vitro of Musa paradisiaca L. and Spondias mombin L. Fractions. Vet Parasitol 2012;187:79-84.
50. Roobha JJ, Saravanakumar M, Aravinthan KM, Devi PS. Antioxidant analysis of anthocyanidin extracted from Musa acuminata bract. J Pharm Res 2011;4:1488-92.
51. Yin X, Quan J, Kanazawa T. Banana prevents plasma oxidative stress in healthy individuals. Plant Foods Hum Nutr 2008;63:71-6.
52. Vijayakumar S, Presannakumar G, Vijayalakshmi NR. Investigations on the effect of flavonoids from banana, Musa paradisiaca L. On lipid metabolism in rats. J Diet Suppl 2009;6:111-23.
53. Singh B, Singh JP, Kaur A, Singh N. Bioactive compounds in banana and their associated health benefits a review. Food Chem 2016;206:1-1.
54. Foster M, Rodriquez ER, Martin JD, Romero CD. Distribution of nutrients in edible banana pulp. Food Tech Biotech 2003;41:167-72.
55. Davey MW, Stals E, Ngoh-Newilah G, Tomekpe K, Lusty C, Markham R, et al. Sampling strategies and variability in fruit pulp micronutrient contents of west and Central African bananas and plantains (Musa species). J Agric Food Chem 2007;55:2633-44.
56. Borges MH, Alves DL, Raslan DS, Piló-Veloso D, Rodrigues VM, Homsi- Brandeburgo MI, et al. Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms. J Ethnopharmacol 2005;98:21-9.
57. Beatrice E, Deborah N, Guy B. Provitamin A carotenoid content of unripe and ripe banana cultivars for potential adoption in Easterm Africa. J Food Compost Anal 2015;43:1-6.
58. Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005;26:459-516.
59. Kumar KS, Bhowmilk D, Duraivel S, Umadeyi M. Traditional and medicinal uses of banana. J Pharmacogn Phytochem 2012;1:2278-4136.
60. Bhaskar JJ. Banana (Musa sp) flower and pseudosteim: Dietary fibre and associated antioxidant capacity. J Agric Food Chem 2011;34:28-34.
61. Lassoudere A. Bananier et sa culture. France, Versaillies: CEDEX; 2007.
62. Lewis DA, Fields WN, Shaw GP. A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. Paradisiaca) protects the gastric mucosa from aspirin-induced erosions. J Ethnopharmacol 1999;65:283-8.
63. Usha V, Vijayammal PL, Kurup PA. Effect of dietary fiber from banana (Musa paradisiaca) on cholesterol metabolism. Indian J Exp Biol 1984;22:550-4.
64. Sabater-Molina M, Larqué E, Torrella F, Zamora S. Dietary fructooligosaccharides and potential benefits on health. J Physiol Biochem 2009;65:315-28.
65. Cressey R, Kumsaiyai W, Mangklabruks A. Daily consumption of banana marginally improves blood glucose and lipid profile in hypercholesterolemic subjects and increases serum adiponectin in Type 2 diabetic patients. Indian J Exp Biol 2014;52:1173-81.
66. Thompson GR, Grundy SM. History and development of plant sterol and stanol esters for cholesterol-lowering purposes. Am J Cardiol 2005;96:3D-9.
67. Sen S, Asokkumar K, Umamaheswari M, Sivashanmugam AT, Subhadradevi V. Antiulcerogenic effect of gallic acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue. Indian J Pharm Sci 2013;75:149-55.
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OLUWAFEMI OMONIYI OGUNTIBEJU. “ANTIDIABETIC, ANTI-INFLAMMATORY, ANTIBACTERIAL, ANTI-HELMINTHIC, ANTIOXIDANT AND NUTRITIONAL POTENTIAL OF MUSA PARADISIACA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 10, July 2019, pp. 9-13, doi:10.22159/ajpcr.2019.v12i10.34239.
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