DIAGNOSTIC VALUE OF RETICULOCYTE HEMOGLOBIN AND SOLUBLE TRANSFERRIN RECEPTOR IN DETERMINING THE IRON STATUS OF CHRONIC KIDNEY DISEASE WITH HEMODIALYSIS PATIENTS

  • DWI LILY LUKAS Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga Academic General Hospital Surabaya, East Java, Indonesia.
  • YETTI HERNANINGSIH Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga Academic General Hospital Surabaya, East Java, Indonesia. https://orcid.org/0000-0001-5253-6956
  • ARI TRIANTANOE Department of Internal Medicine, Dr. M. Soewandhie Regional General Hospital, Surabaya, East Java, Indonesia. https://orcid.org/0000-0001-5253-6956

Abstract

Objective: This research aims to find the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the new parameters reticulocyte hemoglobin (Ret-He), and soluble transferrin receptor (sTfR) in determining the iron status of patients with chronic kidney disease with hemodialysis (CKD-HD) who will receive recombinant human erythropoietin (rHuEPO) therapy which requires sufficient iron levels.


Methods: The cross-sectional study was conducted in Hemodialysis (HD) Unit of Dr. M. Soewandhie Regional General Hospital from September 2018 to March 2019. Patients with CKD and anemia who had undergone hemodialysis were recruited in this study. There were two groups: Group 1, patients with iron-deficiency anemia and Group 2, patients without iron-deficiency anemia. Examination on Ret-He and sTfR was performed through comparison with gold standard transferrin saturation and ferritin serum.


Results: The mean±standard deviation of Ret-He is 30.18±2.74 pg, sTfR of male group is 2704.11±1981 mg/l and sTfR of female group is 3837.76±1415 mg/l. The agreement of Ret-He and gold standard was 85.4% (p=0.000) with sensitivity 86.7%, specificity 84.6%, PPV 76.5%, and NPV 91.7%. The agreement of sTfR in male was 92.8% (p=0.002) with sensitivity 100%, specificity 90.9%, PPV 75%, and NPV 100%. As for female, it was 85.1% (p=0.000), with sensitivity 83.3%, specificity 86.75%, PPV 83.3%, and NPV 86.7%. According to sTfR/log ferritin index calculation, the agreement was 100% (p=0.000) for male and 85.1% (p=0.000) for female.


Conclusion: The diagnostic values of the parameters Ret-He, sTfR, and sTfR/log ferritin index were high and therefore can be used to diagnose iron-deficiency anemia in CKD-HD patients who will undergo rHuEPO therapy.

Keywords: Iron-deficiency anemia, Chronic kidney disease with hemodialysis, Reticulocyte hemoglobin, Soluble transferrin receptor

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DWI LILY LUKAS, YETTI HERNANINGSIH, and ARI TRIANTANOE. “DIAGNOSTIC VALUE OF RETICULOCYTE HEMOGLOBIN AND SOLUBLE TRANSFERRIN RECEPTOR IN DETERMINING THE IRON STATUS OF CHRONIC KIDNEY DISEASE WITH HEMODIALYSIS PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 9, July 2019, pp. 210-4, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34639.
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