DEVELOPMENT AND IN VITRO EVALUATION OF PHYTOSOMES OF NARINGIN

  • JEEVANA JYOTHI B Department of Pharmaceutics, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati - 517 502, Andhra Pradesh, India.
  • MARY RAGALATHA P Department of Pharmaceutics, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati - 517 502, Andhra Pradesh, India.

Abstract

Objective: Phytosomes are novel herbal formulations meant for design of poorly soluble flavonoids of therapeutic potential. Naringin is a flavanone with poor oral absorption and bioavailability but possess antioxidant, anti-inflammatory, antiapoptotic, anti-ulcer, antiosteoporotic, and anticarcinogenic effects. Hence, the objective of the present work is the development of phytosomes of naringin to enhance its dissolution so that its therapeutic effects can be exploited.


Materials and Methods: Phytosomes containing 350 mg of naringin were prepared by antisolvent precipitation method and rotary evaporation method using soya lecithin as main polymer. The prepared phytosomes were evaluated by entrapment efficiency, in vitro drug release studies, and drug-excipient interaction studies.


Results: Phytosomes made by rotary evaporation method evidenced higher dissolution values than phytosomes made by antisolvent precipitation. Formulation F7 containing 350 mg of naringin and 1400 mg of soya lecithin revealed the highest percentage release of 84.5±0.39% in 60 min and 99.7±0.24% in 120 min. The percentage of drug entrapment efficiency values was satisfactory. Fourier-transform infrared spectroscopy spectra of pure naringin and naringin phytosomes revealed no interaction between the drug and polymers used for preparation.


Conclusion: Naringin phytosomes are produced successfully by the rotary evaporation method. Phytosomes made with 350 mg of naringin and 1400 mg of soya lecithin by rotary evaporation method are spherical with a rough outer surface and optimum release characteristics of 84.5±0.39 in 60 min to possess optimum bioavailability and 99.7% in 120 min.

Keywords: Naringin, Flavonoid, Anticancer and Antioxidant, Poor bioavailability, Phytosomes, In vitro dissolution

Author Biography

JEEVANA JYOTHI B, Department of Pharmaceutics, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati - 517 502, Andhra Pradesh, India.

professor

References

1. Chen R, Qi QL, Wang MT, Li QY. Therapeutic potential of naringin: An overview. Pharm Biol 2016;54:3203-10.
2. Semalty A, Semalty M, Singh D, Ravat MS. Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery. J Incl Phenom 2010;67:253-60.
3. Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain DK, et al. Phytosome: A novel drug delivery system for herbal medicines. Int J Pharm Sci Drug Res 2010;2:224-8.
4. Patel J, Patel R, Khambojia K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci 2009;4:363-71.
5. Panduraju T, Reddy MS, Veerareddy PR. Phytosomes; A novel phyto-phospholipid carriers for herbal drug delivery. Int Res J Pharm 2011;2:28-33.
6. Saha S, Sarma A, Saikia P, Chakraborty T. Phytosomes: A brief overview. Sch Acad J Pharm 2013;2:12-20.
7. Agrawal VK, Gupta A, Chaturvedi S. Improvement in bioavailability of class-III drug; phytolipid delivery system. Int J Pharm Pharm Sci 2012;4:37-42.
8. Swati R, Sapna M. Phytosomal drug delivery systems. Int J Res Dev Pharm Life Sci 2012;1:143-50.
9. Khan J, Alexander A, Ajazuddin, Saraf S, Saraf S. Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J Control Release 2013;168:50-60.
10. Avasti R, Kulkarni GT, Pawar V. Phytosomes, an approach to incrse the bioavailability of plant products. Int J Pharm Pharm Sci 2011;3:1-3.
11. Ittadwar PA, Puranik PK. Umbelliferonephytosomes: Development and optimization using experimental design approach and evaluation of photoprotective and antioxidant activity. Int J Pharm Pharm Sci 2016;9:218-28.
Statistics
75 Views | 12 Downloads
How to Cite
JEEVANA JYOTHI B, and MARY RAGALATHA P. “DEVELOPMENT AND IN VITRO EVALUATION OF PHYTOSOMES OF NARINGIN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 9, July 2019, pp. 252-6, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34798.
Section
Original Article(s)