EFFECT OF NOISE STRESS-INDUCED NEUROBEHAVIORAL CHANGES ON WISTAR ALBINO RATS

  • ARCHANA ARJUNAN Department of Physiology, Dr. ALM PG IBMS, University of Madras, Chennai, Tamil Nadu, India.
  • DR. RAVINDRAN RAJAN Department of Physiology, Dr. ALM PG IBMS, University of Madras, Chennai, Tamil Nadu, India.

Abstract

Objective: The study aims to investigate the effect of acute noise stress on cognitive functions in male Wistar albino rats.


Methods: Adult albino rats were randomly divided into two groups. Each group contains six animals. Rats exposed to acute noise stress (100 dB/4 h) were compared with control animal and assessed for cognition using T-maze, hole-board test, open-field test, marble burying test, and social interaction behavior.


Results: The rats exposed to acute noise stress showed the significance (p<0.05) of behavioral alterations such as impaired learning and memory, memory retention, increased fear and anxiety, obsessive–compulsive behavior, social avoidance, and decreased social interaction.


Conclusion: The results report that acute noise stress affects the cognition, and it became chronic may confer the increased risk of neurodegenerative disorders.

Keywords: Cognition, Learning, Noise, Stress, Neurodegenerative disease, Social interaction

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How to Cite
ARCHANA ARJUNAN, and RAVINDRAN RAJAN. “EFFECT OF NOISE STRESS-INDUCED NEUROBEHAVIORAL CHANGES ON WISTAR ALBINO RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 10, July 2019, pp. 78-82, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34843.
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