EFFECT OF FATTY ACID BASED FUNCTIONAL LIPIDOMICS IN WOMEN WITH BREAST CANCER

  • PREETHIKA A Research Scholar, K S Hegde Medical Academy, Mangaluru, Karnataka.
  • SUCHETHA KUMARI N Department of Biochemistry, K S Hegde Medical Academy, Mangaluru, Karnataka.

Abstract

Objective: Lipid metabolism alteration is a prominent feature during malignant transformation. We investigated the difference in plasma fatty acids (FAs) and molecular biomarkers in breast cancer women and controls.


Methods: This comparative study was carried out on eighty breast cancer women and forty control women. FAs were analyzed in gas chromatography and calculated as a percentage of total FAs. FA molecular markers were estimated by the FA data. Non-parametric statistical tests were used.


Results: Saturated FAs were higher in the case group. Control group had higher linoleic acid (p=0.04), suggesting decreased desaturase activity. N-6 FAs were higher and n-3 FAs were lower in breast cancer cases. The n6/n3 ratio, cardiovascular risk ratio (p<0.001), and inflammatory risk ratio were high, whereas saturation index and unsaturation index (p=0.05) were lower in breast cancer cases.


Conclusion: Lipidomics of the cell membrane is significantly influenced by FAs, and the dietary FAs regulate the enzymatic activities in the FA metabolism pathway.

Keywords: Functional lipidomics, Fatty acids, Breast cancer, Cell membrane fatty acid profile, Fatty acid profile

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PREETHIKA A, and SUCHETHA KUMARI N. “EFFECT OF FATTY ACID BASED FUNCTIONAL LIPIDOMICS IN WOMEN WITH BREAST CANCER”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 10, Aug. 2019, pp. 138-41, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34888.
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