GASTROPROTECTIVE ACTIVITY OF SESAME (SESAMUM INDICUM) SEEDS EXTRACT IN ALENDRONATE INDUCED GASTRIC ULCER IN RATS.
Background: Bisphosphonates are known to cause gastritis and only few studies have evaluated the use of plant extracts in the treatment of bisphosphonate induced peptic ulcers. In the present study, we examined the effect of sesame seed extract in the alendronate-induced gastric ulcer in adult Wistar rats.
Methods: Thirty adult Wistar rats (180-250 g) of both sexes, divided into five groups (N=6) were used. Group 1 (vehicle control)-0.9% saline, Group 2 (ulcer control)- Alendronate 60mg/kg, Group 3 (standard)- Alendronate 60mg/kg + Pantoprazole 30mg/kg/day, Group 4 (test groups)- Alendronate 60mg/kg + Sesame 0.5mg/kg, Group 5 (test groups) – Alendronate 60mg/kg + Sesame 1mg/kg. All drugs given orally once daily for 7 days except for alendronate given only on day one. On day 8, rats were sacrificed, and stomach tissues were analysed macroscopically for ulcers. Estimation of gastric pH, acidity and volume was done along with mucin content measurement. One- way Anova followed by Tukey’s post hoc test was used for statistical analysis with p value (<0.05) taken as significant.
Results: Our study found that sesame extract given therapeutically at doses of 0.5 and 1 mg/kg showed comparable results with that of pantoprazole 30mg/kg. Both the doses of sesame, 0.5 & 1mg/kg showed similar gastroprotective activity against alendronate induced gastric ulcers in Wistar rats.
Conclusion: The findings of this study clearly demonstrate the protective effects of Sesame against Alendronate-induced gastric ulceration.
Key words: Gastroprotection, Sesame, alendronate, gastric ulcers.
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