PRELIMINARY PHYTOCHEMISTRY AND ANTIDIABETIC ACTIVITY OF PORTULACA GRANDIFLORA H. PLANT EXTRACT ON STREPTOZOTOCIN INDUCED DIABETES IN RATS
Background: Diabetes mellitus (DM) is global health problem and the incidence of DM is increasing at alarming rate all over the world.
Objective: The present study aimed to evaluate antidiabetic activity of ethanolic extract of whole aerial plant of Portulaca grandiflora H. on Streptozotocin induced diabetic rats.
Material and Methods: Experimental diabetes was induced in by single dose of intraperitoneal injection of streptozotocin(150mg/kg). Adult male Wister albino rats were divided into five groups; normal control, diabetic control, diabetic glibenclamide (5mg/kg) diabetic Portulaca grandiflora H. extract (200 mg/kg) and diabetic Portulaca grandiflora H. extract (400 mg/kg) for 21 days and analysed for body weight and blood glucose.
Results: The streptozotocin treated diabetic control rats showed a significant increase in blood glucose with concomitant decrease in body weight. Oral administration of Portulaca grandiflora H. extract (200 and 400 mg/kg) and glibenclamide (5mg/kg) for 21 days showed significant reduction in blood glucose levels and elevation in the body weight studies as compared to control andglibenclamide treated rats.
Conclusion: The results of present study showed that aerial part of plant Portulaca grandiflora H. extract possess potent antidiabetic activity.
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