PRELIMINARY PHYTOCHEMISTRY AND ANTIDIABETIC ACTIVITY OF PORTULACA GRANDIFLORA H. PLANT EXTRACT ON STREPTOZOTOCIN INDUCED DIABETES IN RATS

  • KOMAL RAO Dr. MGR Educational and Resaerch Institute, Chennai

Abstract

Background: Diabetes mellitus (DM) is global health problem and the incidence of DM is increasing at alarming rate all over the world.


Objective: The present study aimed to evaluate antidiabetic activity of ethanolic extract of whole aerial plant of Portulaca grandiflora H. on Streptozotocin induced diabetic rats.


Material and Methods: Experimental diabetes was induced in by single dose of intraperitoneal injection of streptozotocin(150mg/kg). Adult male Wister albino rats were divided into five groups; normal control, diabetic control, diabetic glibenclamide (5mg/kg) diabetic Portulaca grandiflora H. extract (200 mg/kg) and diabetic  Portulaca grandiflora H. extract (400 mg/kg) for 21 days and analysed for body weight and blood glucose.


Results: The streptozotocin treated diabetic control rats showed a significant increase in blood glucose with concomitant decrease in body weight. Oral administration of Portulaca grandiflora H. extract (200 and 400 mg/kg) and glibenclamide (5mg/kg) for 21 days showed significant reduction in blood glucose levels and elevation in the body weight studies as compared to control andglibenclamide treated rats.


Conclusion: The results of present study showed that aerial part of plant Portulaca grandiflora H. extract possess potent antidiabetic activity.

Keywords: Diabetes mellitus, ethanolic extract, Portulaca quadrifida, glibenclamide, Blood glucose, Streptozotocin
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RAO, K. “PRELIMINARY PHYTOCHEMISTRY AND ANTIDIABETIC ACTIVITY OF PORTULACA GRANDIFLORA H. PLANT EXTRACT ON STREPTOZOTOCIN INDUCED DIABETES IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, https://innovareacademics.in/journals/index.php/ajpcr/article/view/35216.
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