SHELF-LIFE ASSESSMENT OF DANTASHODHANA PASTE (A POLYHERBAL TOOTHPASTE): A PRELIMINARY STUDY

  • DHARA MAKWANA Department of Shalakya Tantra, Murlidhar Ayurveda College, Rajkot, Gujarat, India.
  • GALIB R Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India.
  • PARTH PRAKASHBHAI DAVE Department of Ayurveda, RRAP Central Ayurveda Research Institute for Cancer, Mumbai, India.
  • MANJUSHA RAJAGOPALA Department of Shalakyatantra, All India Institute of Ayurveda, New Delhi, India.
  • PRADEEP KUMAR PRAJAPATI Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India.

Abstract

Objective: Shelf life is the period during which the potency (Virya) of a drug remains unaffected due to environmental factors or from microbial contamination. Considering the growing popularity of Ayurveda products, it becomes important to maintain the quality of all such products. Shelf life is one of the essential components under quality and needs to be evaluated for all products. Dantashodhana paste (DP) is a polyherbal toothpaste containing Vyosha (Zingiber officinale Roxb., Piper nigrum Linn., and Piper longum Linn.), Trijata (Cinnamomum zeylanicum Blume., Elettaria cardamomum Maton., Cinnamomum tamala (Buch.-Ham.) T.Nees and Eberm.), Tejovati (Zanthoxylum armatum DC.), Saindhava (rock salt), and other excipients.


Methods: DP was prepared with the following standard guidelines. The samples were subjected to accelerated stability study by maintaining temperature and humidity 40±2°C and 75±5%, respectively. Relevant analytical parameters were analyzed at an interval of 0, 1, 3, and 6 months to check the degradation levels in the formulation.


Results: DP was found to be free from microbial contamination. Heavy metals were within the prescribed limits for toothpaste complying the official standards. There were insignificant changes in physicochemical profiles at different intervals. On extrapolation of the observations, the shelf life of DP was found to be 12.16 years.


Conclusion: Shelf life of DP is found to be much longer than the standards specified in the D and C act. This prolonged shelf life may be contributed to care taken during drug preparation, storage, and properties of herbal drugs used in the formulation.

Keywords: Ayurveda, Dantashodhana paste, Polyherbal toothpaste, Saviryata avadhi, Shelf life

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MAKWANA, D., G. R, P. P. DAVE, M. RAJAGOPALA, and P. K. PRAJAPATI. “SHELF-LIFE ASSESSMENT OF DANTASHODHANA PASTE (A POLYHERBAL TOOTHPASTE): A PRELIMINARY STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 4, Feb. 2020, pp. 79-83, doi:10.22159/ajpcr.2020.v13i4.35243.
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