IN VITRO STUDIES ON THE ANTI-DIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-AMYLASE AND α-GLUCOSIDASE
Objective: The aim of the present study was to investigate the inhibitory effect of 2-thiohydantoin on the enzymes α-amylase and α-glucosidase in vitro as an anti diabetic therapeutic approach to reduce gastrointestinal glucose production.
Method: Antidiabetic activity of the compound, 2-Thiohydantoin was measured using the enzymes α-amylase and α-glucosidase.
Result: IC50 of the antidiabetic α-amylase was found to be 410.35 µg/ml and α-glucosidase was found to be 356.33 µg/ml respectively.
Conclusion: The result obtained in the in vitro enzyme assay suggest the antidiabetic acitivity of 2-Thiohydantoin.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.