IN VITRO STUDIES ON THE ANTI-DIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-AMYLASE AND α-GLUCOSIDASE

  • S.UMA SIVALINGAM ASST.PROFESSOR

Abstract

Objective: The aim of the present study was to investigate the inhibitory effect of 2-thiohydantoin on the enzymes α-amylase and α-glucosidase in vitro as an anti diabetic therapeutic approach to reduce gastrointestinal glucose production.


Method: Antidiabetic activity of the compound, 2-Thiohydantoin was measured using the enzymes α-amylase and α-glucosidase.


Result: IC50 of the antidiabetic α-amylase was found to be 410.35 µg/ml and α-glucosidase  was found to be 356.33 µg/ml respectively.


Conclusion: The result obtained in the in vitro enzyme assay suggest the antidiabetic acitivity of 2-Thiohydantoin.

Keywords: Enzyme inhibition
Statistics
9 Views | Downloads
How to Cite
SIVALINGAM, S. “IN VITRO STUDIES ON THE ANTI-DIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-AMYLASE AND α-GLUCOSIDASE ”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, https://innovareacademics.in/journals/index.php/ajpcr/article/view/35320.
Section
Original Article(s)