DEVELOPMENT, EVALUATION, AND CHARACTERIZATION OF LOSARTAN POTASSIUM BUCCAL PATCHES USING JACKFRUIT POLYMER

BUCCAL PATCH

  • SOJI S Department of Pharmaceutics, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India.
  • ARUN JL Department of Pharmaceutics, The Dale View College of Pharmacy and Research Centre, Thiruvananthapuram, Kerala, India.

Abstract

Objective: The objective was to develop buccal patches of an antihypertensive drug and losartan potassium using jackfruit polymer for sustained buccal delivery.


Methods: The patches were prepared by the solvent casting method. Five formulations were developed with varying concentrations of jackfruit polymer. USP type II apparatus was used to perform in-vitro release study under perfect sink condition. Buccal formulations were developed to a satisfactory level in terms of drug release, bioadhesive strength, content uniformity, moisture content, surface pH, thickness, and stability study.


Results: From the results obtained F5 was found as best formulation, having appropriate folding endurance greater than 300, moisture content of 1.14±0.03 percentage (%), moisture uptake of 6.21±0.12%, swelling index (62.78%), bioadhesion strength (37.62±0.25 g), and bioadhesion time of 9 h 5 min. Fourier-transform infrared spectroscopy studies have shown no interactions between drug and polymer. All the formulations followed zero-order kinetics.


Conclusion: It can be concluded that mucoadhesive buccal patches of losartan potassium using jackfruit polymer are an auspicious dosage form to prolong the release of drug and enhance its poor oral bioavailability.

Keywords: Buccal patches, Jackfruit polymer, Solvent casting

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SOJI S, and ARUN JL. “DEVELOPMENT, EVALUATION, AND CHARACTERIZATION OF LOSARTAN POTASSIUM BUCCAL PATCHES USING JACKFRUIT POLYMER”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 11, Sept. 2019, pp. 24-30, doi:10.22159/ajpcr.2019.v12i11.35323.
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