TOPICAL SOLID LIPID NANOPARTICLES BASED GEL OF LAVENDER ESSENTIAL OIL FOR ANTI‑INFLAMMATORY ACTIVITY

PALLAVI M CHAUDHARI; VAISHNAVI M BIND

doi:10.22159/ajpcr.2019.v12i11.35459

Authors

PALLAVI M CHAUDHARI Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Pune, Maharashtra, India.
VAISHNAVI M BIND Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Pune, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i11.35459

Keywords:

Anti-inflammatory activity, Lavender essential oil, Solid lipid nanoparticles

Abstract

Objective: The main objective of the study was to formulate and evaluate and perform an optimization study of lavender essential oil loaded solid lipid nanoparticles (SLNs) based gel.

Materials and Methods: SLNs were prepared by the hot homogenization technique. A total of eight formulations were formulated as per 23 factorial design by design expert 11 software. The formulated SLNs were further evaluated for particle size, entrapment efficiency, drug release profile. After evaluation, the optimized batch was further used for formulating gel. The formulated gel was further subjected to ex vivo studies.

Results: After the evaluation of all the parameters, batch 7 was found to be optimized. Batch 7 was found to have the lowest particle size of 30.91±0.30, higher entrapment efficiency of 89.99±0.87, and higher drug release of 90.41±0.55. It was further used for formulating gel which was found to be consistent, homogenous, smooth, and spreadable. The % inhibition of the formulated SLN based gel was found to be 28±0.1%.

Conclusion: The SLNs were prepared and were formulated into the gel. The gel showed anti-inflammatory activity.

Downloads

Download data is not yet available.

References

Vashishtha V, Sharma G, Gaur M, Bairwa R. A review on some plants having anti-inflammatory activity. J Phytopharm 2014;3:214-21.

Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq Yap YH, Hezmee MNM, et al. The crucial roles of inflammatory mediators in inflammation: A review. Vet World 2018;11:627-35.

Ward PA, Lentsch AB. The acute inflammatory response and its regulation. Arch Surg 1999;134:666-9.

Verma S, Makkar D. Solid lipid nanoparticles: A comprehensive review. J Chem Pharm Res 2016;8:102-14.

Ekambaram P, Sathali A. Solid lipid nanoparticles: A review. Sci Rev Chem Commun 2012;2:20-102.

Cardia GFE, Silva-Filho SE, Silva EL, Uchida NS, Cavalcante HAO, Cassarotti LL, et al. Effect of lavender (Lavandula angustifolia) essential oil on acute inflammatory response. Evid Based Complement Alternat Med 2018;2018:1413940.

Vijayan V, Shaikh A, Sakthivel S, Reddy R. Formulation and characterization of solid lipid nanoparticles loaded neem oil for topical delivery. J Acute Dis 2013;2:282-6.

Nasseri M, Golmohammadzadeh S, Arouiee H, Jaafari MR, Neamati H. Antifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition. Iran J Basic Med Sci 2016;19:1231-7.

Wencui Z, Qi Z, Ying W, Di W. Preparation of solid lipid nanoparticles loaded with garlic oil and evaluation of their in vitro and in vivo characteristics. Eur Rev Med Pharmacol Sci 2015;19:3742-50.

Shi F, Zhao JH, Liu Y, Wang Z, Zhang YT, Feng NP, et al. Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil. Int J Nanomedicine 2012;7:2033-43.

Aland R, Ganesan M, Rao R. In vivo evaluation of tazarotene solid lipid nanoparticles gel for topical delivery. Int J Pharm Sci Drug Res 2019;11:45-50.

Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, et al. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol 2017;23:4200-10.

Khare A, Singh I, Pawar P, Grover K. Design and evaluation of voriconazole loaded solid lipid nanoparticles for ophthalmic application. J Drug Deliv 2016;2016:6590361.

Jourghanian P, Ghaffari S, Ardjmand M, Haghighat S, Mohammadnejad M. Sustained release curcumin loaded solid lipid nanoparticles. Adv Pharm Bull 2016;6:17-21.

Shilpa N, Chakravarthi N. Moxifloxacin loaded solid lipid nanoparticles preparation and characterization. Asian J Pharm Res 2012;2:105-12.

Madan JR, Khude PA, Dua K. Development and evaluation of solid lipid nanoparticles of mometasone furoate for topical delivery. Int J Pharm Investig 2014;4:60-4.

Khalil R. Solid Lipid Nanoparticles for Topical Delivery of Meloxicam. Portugal: Annual International Interdisciplinary Conference 2013. p. 24-6.

Kushwaha AK, Vuddanda PR, Karunanidhi P, Singh SK, Singh S. Development and evaluation of solid lipid nanoparticles of raloxifene hydrochloride for enhanced bioavailability. Biomed Res Int 2013;2013:584549.

Gupta R, Gupta G. Formulation, development and evaluation of anti-inflammatory potential of cordia obliqua topical gel on animal model. Pharmacogn J 2017;9:s93-8.

Kuchekar M, Mohite M, Phadtare G. Formulation and evaluation test for voriconazole gel. Eur J Pharm Med Res 2016;3:466-70.

Damor B, Dashora A, Parra S. Evaluation of analgesic and anti-inflammatory activity of methanolic extract of Guazuma ulmifolia. J Appl Pharm Sci Res 2018;1:23-9.

Shah D, Gupta A, Shah Y. Effect of lipid and surfactant concentration on cefpodoxime proxetil solid lipid nanoparticles. Eur J Biomed Pharm Sci 2017;4:817-23.

Ekambaram P, Abdul HS. Formulation and evaluation of solid lipid nanoparticles of ramipril. J Young Pharm 2011;3:216-20.

Bhalekar M, Upadhyay P, Madgulkar A. Formulation and characterization of solid lipid nanoparticles for anti-retroviral drug darunavir. Appl Nanosci 2017;7:47-57.

Shah R, Eldridge D, Palombo E, Harding I. Optimization and stability assessment of solid lipid nanoparticles using particle size and zeta potential. J Phys Sci 2014;25:59-75.

Kasar P, Kale K, Phadtare D. Formulation and evaluation of topical antifungal gel containing itraconazole. Int J Curr Pharm Res 2018;10:71-4.