Study on the association of obesity indices with inflammatory markers in in pre-diabetes and diabetes
Due to the plethora of health and economic burden, overweight and obesity have become a major epidemic. Obesity is associated with a pro-inflammatory state with increased circulating pro-inflammatory and decreased anti-inflammatory molecules. Diabetes mellitus and cardiovascular disorders (CVDs) are the serious outcomes of obesity and obese diabetic individuals are further at high risk of CVDs. Thus in this study, an attempt was made to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes.
This study recruited 300 participants (100 control group, 100 pre-diabetic group and 100 diabetic group). The anthropometric variables like BMI, WHR and WC, and biochemical variables like fasting blood glucose, HbA1c, uric acid, CRP, fibrinogen, IL-6 and adiponectin were analysed in each participant by standard methods.
The present study documented significantly high values of BMI and WHR in patients (pre-diabetic and diabetic) group compared to the control group. Similarly, the level of adiponectin decreased and that of uric acid, CRP, fibrinogen and IL-6 increased significantly. Both BMI and WC were correlated significantly with inflammatory mediators in diabetic patients. The correlation with adiponectin was negative. In pre-diabetic group, a significant correlation was observed only between WHR, adiponectin and uric acid.
This study supports the fact that obesity-induced systemic inflammation of low grade is significantly associated with pre-diabetes and diabetes thereby keeping these individuals at high risk of future complications especially CVDs.
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