STUDY ON THE ASSOCIATION OF OBESITY INDICES WITH INFLAMMATORY MARKERS IN PRE-DIABETES AND DIABETES

  • PRADEEP KUMAR Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
  • SHAILAZA SHRESTHA Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
  • MAHENDRA PRASAD Department of Biochemistry, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India.
  • PREETI SHARMA Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
  • MOHIT Department of Biochemistry, Autonomous State Medical College and Hospital, Basti, Uttar Pradesh, India.

Abstract

Objective: In this study, the main objective was to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes.


Methods: This study recruited 300 participants (100 control group, 100 pre-diabetic group, and 100 diabetic group). The anthropometric variables such as body mass index (BMI), waist-hip ratio (WHR), and waist circumference (WC), and biochemical variables such as fasting blood glucose, glycated hemoglobin, uric acid, C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), and adiponectin were analyzed in each participant by standard methods.


Results: The present study documented significantly high values of BMI and WHR in patient (pre-diabetic and diabetic) groups compared to the control group. Similarly, the level of adiponectin decreased and that of uric acid, CRP, fibrinogen, and IL-6 increased significantly. Both BMI and WC were correlated significantly with inflammatory mediators in diabetic patients. The correlation with adiponectin was negative. In the pre-diabetic group, a significant correlation was observed only between WHR, adiponectin, and uric acid.


Conclusion: This study supports the fact that obesity-induced systemic inflammation of low grade is significantly associated with pre-diabetes and diabetes, thereby keeping these individuals at high risk of future complications especially cardiovascular diseases.

Keywords: Obesity, Inflammation, Pre-diabetes, Diabetes

Author Biography

PRADEEP KUMAR, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.

Asst.Professor, Department of Biochemistry.

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PRADEEP KUMAR, SHAILAZA SHRESTHA, MAHENDRA PRASAD, PREETI SHARMA, and MOHIT. “STUDY ON THE ASSOCIATION OF OBESITY INDICES WITH INFLAMMATORY MARKERS IN PRE-DIABETES AND DIABETES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, pp. 64-68, doi:10.22159/ajpcr.2019.v12i12.35588.
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