The IMPACT OF DIFFERENT REGIMENS OF VITAMIN D3 ON GLUCOSE HOMEOSTASIS IN TYPE 2 DIABETIC PATIENTS
AbstractObjective: Vitamin D3 has a role in the regulation of pancreatic β-cell function and insulin sensitivity. Accordingly, vitamin D deficiency is considered as a risk factor for the development of type 2 DM and its complications. Therefore, the aim of the study was to assess and compare the effect of different regimens of vitamin D3 on glucose homeostasis in type 2 diabetic patients.
Methods: The study included 80 type 2 diabetic patients on oral anti-diabetic drugs. They were randomized to receive anti-diabetic drugs alone or with different regimens of vitamin D3 for 3 months. Vitamin D3 treated patients were supplemented by either daily oral 4000 IU vitamin D3, weekly oral 50,000 IU vitamin D3 or a single parenteral 300,000 IU vitamin D3. In addition to assessment of patient characteristics, laboratory measurements of serum creatinine, blood urea, total and ionized Ca, serum phosphorus, fasting blood glucose (FBG), fasting serum insulin, homeostatic model assessment-insulin resistance (HOMA-IR), hemoglobin A1c (HbA1c), and 25(OH)Vit D levels were measured at the beginning and after 3 months.
Results: After 3 months, the increased vitamin D levels resulted from the daily and weekly oral doses of vitamin D3 caused a significant decrease in metabolic parameters. While, parenteral dose demonstrated a non-significant decline.
Conclusion: Oral daily and weekly doses of vitamin D3 could improve glucose homeostasis equally in type 2 diabetic patients and superior to the single parenteral dose of vitamin D3.
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