BILAYER TABLET TENDERED IMMEDIATE RELEASE OF PARACETAMOL AND SUSTAINED RELEASE OF IBUPROFEN FOR QUICK ONSET OF ACTION AGAINST PAIN AND FEVER

  • DEVENDER CHAUHAN Department of Hindu College of Pharmacy, Sonipat, Haryana, India.
  • DINESH KAUSHIK Department of Hindu College of Pharmacy, Sonipat, Haryana, India.

Abstract

Objective: The objective of this research was to formulate bi-layer tablet which contains immediate-release layer of Paracetamol for quick onset of action and sustained release of Ibuprofen for prolonging long period.


Materials and Methods: The following chemicals were used: Paracetamol (Combiotic Global Pvt. Ltd., India), Ibuprofen (Combiotic Global Pvt. Ltd., India), microcrystalline cellulose (MCC) (Avicel), and Polyvinylpyrrolidone (PVP) K-30 (Loba Chem). Wet granulation method was adapted to formulate the bilayer tablets. The immediate-release layer of Paracetamol was prepared using sodium starch glycolate as superdisintegrants, MCC as diluent, starch as binder. The sustained release layer of Ibuprofen was prepared using high-performance liquid chromatography E50LV and ethyl cellulose as binder along with other excipients such as MCC, PVP, and magnesium stearate by wet granulation technique.


Result and Discussion: The release rate of Paracetamol from Formulations 1 was more than 80% at 40 min. In case of Ibuprofen, sustained-release polymers such as HPMC E50 LV were used to increase the release time.


Conclusion: The bilayer tablets were prepared and show good release rate.

Keywords: Paracetamol, Ibuprofen, Analgesic, Immediate release, Sustained release, High-performance liquid chromatography

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DEVENDER CHAUHAN, and DINESH KAUSHIK. “BILAYER TABLET TENDERED IMMEDIATE RELEASE OF PARACETAMOL AND SUSTAINED RELEASE OF IBUPROFEN FOR QUICK ONSET OF ACTION AGAINST PAIN AND FEVER”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 11, Oct. 2019, pp. 166-74, doi:10.22159/ajpcr.2019.v12i11.35690.
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