EVALUATION OF ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE SEEDS OF VIGNA ACONITIFOLIA (HEVA) IN WISTAR ALBINO RAT

  • SUSHMITA RANAPRATAP SINGH DEPARTMENT OF PHARMACOLOGY

Abstract

ABSTRACT


Objective: The objective of the study is to evaluate the antiparkinsonian activity of hydroalcoholic extract of the seeds of vigna aconitifolia (HEVA) in wistar albino rat.


 Materials and Methods:. In rats,catalepsy was induced using haloperidol (4 mg/kg i.p.). Treatment groups received bromocriptine (4 mg/kg) and HEVA at the dose of (100, 200, and 300 mg/kg) orally. Bar test for catalepsy, motor coordination test by rotarod, and locomotor activity by actophotometer were carried out  to assess behavioral changes. Assay of dopamine and catalase were also carried out to assess biochemical parameters.


Results: Bromocriptine and HEVA-treated groups showed significant difference in behavioral and biochemical parameters as compared to haloperidol control group in the experimental models.


Conclusion: Vigna Aconitifolia seeds exhibited significant antiparkinsonian activity in haloperidol mouse model .

Keywords: Vigna Aconitifolia, Catalepsy, Haloperidol ,wistar albino rat

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SINGH, S. R. “EVALUATION OF ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE SEEDS OF VIGNA ACONITIFOLIA (HEVA) IN WISTAR ALBINO RAT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, https://innovareacademics.in/journals/index.php/ajpcr/article/view/35693.
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