• SUSHMITA SINGH Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
  • IMTIYAZ ANSARI Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.




Vigna aconitifolia, Catalepsy, Haloperidol, Wistar albino rat


Objective: The objective of the study is to evaluate the antiparkinsonian activity of hydroalcoholic extract of the seeds of Vigna aconitifolia (HEVA) in Wistar albino rat.

Methods: In rats, catalepsy was induced using haloperidol (4 mg/kg i.p.). Treatment groups received bromocriptine (4 mg/kg) and HEVA at the dose of (100, 200, and 300 mg/kg) orally. Bar test for catalepsy, motor coordination test by rotarod, and locomotor activity by actophotometer were carried out to assess behavioral changes. Assay of dopamine and catalase was also carried out to assess biochemical parameters.

Results: Bromocriptine and HEVA-treated groups showed a significant difference in behavioral and biochemical parameters as compared to haloperidol control group in the experimental models.

Conclusion: Vigna aconitifolia seeds exhibited significant antiparkinsonian activity in haloperidol mouse model.


Download data is not yet available.


Sandhu KS, Cranab A. Evaluation of anti Parkinson’s activity of Nigella sativa (Kalonji) seeds in chlorpromazine induced experimental animal model. Int J Pharm Pharm Sci 2013;5:884-8.

Suvarna P, Ingale SB. Antioxidant and antiparkinsonian activity of Passiflora incarnate leaves. Orient Pharm Exp Med 2014;14:231-6.

Davie CA. A review of parkinson’s disease. Br Med Bull 2008;86:109-27.

Dickson DV. Neuropathology of movement disorders. In: Tolosa E, Jankovic JJ, editors. Parkinson’s Disease and Movement Disorders. Hagerstown, MD: Lippincott Williams and Wilkins; 2007. p. 271-83.

Duty S, Jenner P. Animal models of parkinson’s disease: A source of novel treatments and clues to the cause of the disease. Br J Pharmacol 2011;164:1357-91.

Pemminati S, Nair V, Dorababu P, Gopalakrishna H, Pai M. Effect of ethanolic leaf extract of Ocimum santum on haloperidol-induced catalepsy in albino mice. Indian J Pharmacol 2007;39:87-9.

Roy F, Boye JI, Simpson BK. Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil. Food Res Int 2010;43:432-42.

Marg KS. L-dopa bearing plants. Nat Prod Rad 2003;2:126-33.

Dakshayini PN, Piler B, Boob M. Phytochemical screening and in vitro antioxidant potential of Tribulus terrestris fruit and Mesua ferrea flower extracts: A comparative study. Int J Pharm Pharm Sci 2018;10:70.

Khandelwal KR. Practical Pharmacognosy: Techniques and Experiments. 6th ed. Maharashtra: Nirali Prakashan; 2008.

Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 34th ed. India: Nirali Prakashan; 2008.

OECD. Organization for Economic Co-operation and Development Guidelines for Testing Chemicals, Acute Oral Toxicity. Paris: OECD; 1992. p. 98-101.

Bishnoi M, Chopra K, Kulkarni SK. Involvement of adenosinergic receptor system in an animal model of tardive dyskinesia and associated behavioural, biochemical and neurochemical changes. Eur J Pharmacol 2006;552:55-66.

Kulkarni SK. Hand Book of Experimental Pharmacology. Delhi: Vallabh Prakashan; 1987.

Goyal RK. Practical in Pharmacology. 5th ed. Ahmedabad: B. S. Shah Prakashan; 2005.

Fujikawa T, Miguchi S, Kanada N, Nakai N, Ogata M, Suzuki I, et al. Acanthopanax senticosus harms as a prophylactic for MPTP-induced parkinson’s disease in rats. J Ethnopharmacol 2005;97:375-81.

Babu SB. Development and validation of liquid chromatographic method for the simultaneous estimation of levodopa, carbidopa and entacapone in the combined dosage form. J Pharm Res 2014;8:281-8.

Aebi H. Catalase in vitro, in Methods in Enzymology. New York, USA: Academic Press; 1984. p. 105, 121-6.



How to Cite

SUSHMITA SINGH, and IMTIYAZ ANSARI. “EVALUATION OF ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE SEEDS OF VIGNA ACONITIFOLIA IN WISTAR ALBINO RAT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 12, Dec. 2019, pp. 143-8, doi:10.22159/ajpcr.2019.v12i12.35693.



Original Article(s)