EVALUATION OF ANTIPYRETIC AND ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF TREMA ORIENTALIS L. IN ALBINO WISTAR RATS.
BACKGROUND: The purpose of the present study was aimed at evaluating the antipyretic and antiulcer activity on leaves of Trema orientalis L. (Family Cannabaceae) on Albino Wistar rats. The antipyretic & antiulcer activity of the ethanolic extract of the Trema orientalis L. leaves in three different concentrations (100, 200 and 300 mg/kg) were compared with standard Paracetamol & Pantoprazole, which was evaluated by employing Brewer’sYeast-induced pyrexia & ethanol-induced ulcer model. The Biochemical parameters like the volume of gastric juice secretion, pH, total acidity, ulcer index, percentage protection & lipid peroxidation were also studied.
MATERIALS AND METHOD: T.orientalis leaves was etracted with ethanol by soxhlet extraction method. The dried extract was used for further phytochemical and pharmacological analysis.The antipyretic effect was studied using Brewer.s yeast induced pyrexia. The Ethanol induced ulcer model was used to study the antiulcer effect
RESULT: The percentage yield of Ethanolic extract of T. orientalis leaves were 6.71%w/w respectively. The extract showed significant antipyretic and antiulcer effect when compared with standard paracetamol and pantoprazole.
CONCLUSION: The ethanolic extract of T.orientalis has significant antipyretic and antiulcer action
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