Objective: The aim of this study is to prepare oral controlled release of mucoadhesive alginate microbeads encapsulating fluvastatin by gastro retention technology.


Methods: The mucoadhesive microbeads containing fluvastatin were produced by using emulsification internal gelation technique. The effect of different variables like sodium alginate concentration and its combination with other hydrophilic polymers, the effect of various curing agents on particle size, entrapment efficiency and in-vitro studies were evaluated.


Results: There was no marked change in drug entrapment efficiency, and dissolution studies occurs during the stability studies of fluvastatin. The in-vitro results gives data that improvement in the controlled release of the drug from microbeads compared with marketed tablet. So in this regards, to minimize the frequency of drug administration to reduce side effects. The optimum condition for preparation of stable alginate beads and produce controlled release manner was occurs at higher concentration of combined polymer mixture in equal ratios i.e 3% w/v. Infrared spectroscopic study (FTIR) confirmed the no incompatibility between drug and other excipients. X-ray diffraction study (XRD) and differential scanning colorymetry (DSC) were provide evidence that successful entrapment of drug into the alginates microbeads and drug converted into amorphous nature. The efficiency of mucoadhesion strength of microbeads determined by wash-off study


Conclusion: The kinetic modeling of the release data indicates drug release from the microbeads follow anomalous transport mechanism and super case-II transport mechanism. Drug release is function of pH dependent and controlled drug release depends upon type and concentration of polymer blend and curing agents. The release kinetics of drug from the alginate beads followed zero order.

Keywords: Fluvastatin, Emulsification internal gelation, Sodium alginate, HPMC 50cps, In-vitro wash off study and Swelling index.

Keywords: Keywords: Fluvastatin, Emulsification internal gelation, Sodium alginate, HPMC 50cps, In-vitro wash off study and Swelling index.

Author Biography



dept of pharmacy


1. Sounfeng L, Daggy BP, Mirchandani HL, Chein YW. Effect of HPMC and carbopol on the release and floating properties of gastric floating drug delivery systems using factorial design. Int J Pharm 2003;253: 13-22.
2. Arora S, Ali J, Ahuja A, Khar R K and Baboota S. Floating Drug Delivery Systems: A Review. AAPS PharmSciTech 2005;6: 372-90.
3. Chien YW, Shoufeng Li, Lin S, Daggy BP. Effect of formulation variables on the floating properties of gastric floating drug delivery system. Drug Dev Ind Pharm 2002; 28: 783-79.
4. Toda T, Eliasson E, Ask B, Inotsume N, Rane A. Basic Clin Pharmacol Toxicol 2009;105: 327-32
5. Sirbu C, Tomuta I, Achim M, Rus LL, Vonica L, Dinte E. Quantitative characterization of powder blends for tablets with indapamide by near infrared spectroscopy and chemometry. Farmacia 2014;62;1: 48-57.
6. Funami T, Fang Y, Noda S, Ishihara S. Nakauma M, Draget KI. Rheological properties of sodium alginate in an aqueous system during gelation in relation to super molecular structures and Ca2+ binding. Food Hydrocoll 2009;23: 1746-55.
7. Tokumara Tadakaz, Machida Yoshiharn. Preparation of amoxicillin antragastric buoyant sustained release tablets and dissolution characteristics. J Controlled Release. 2006;110: 581- 86.
8. Chavanpatil D M, Jain P, Choudhari S, Shear R, Vavia RP. Novel sustained release, swellable and bioadhesive gastro retentive drug delivery system for ofloxacin. Int J Pharm 2006;316: 86-92.
9. Nur AO, Zhang JS. Captopril floating and /or bioadhesive tablets: design and release kinetics. Drug Dev Ind Pharm 2000;26: 965-69.
10. Piyakulawat P, Praphairaksit N, Chantarsiri N and Muangsin N. Preparation and evaluation of chitosan/carragenan beads for controlled release of sodium diclofenac. AAPS Pharm SciTech 8: 120-130.
11. Venkata ramana reddy K. The role of needle in formulation of pH sensitive swellable microbeads prepared with hydrophilic polymers for atorvastatin and their characterization studies. Int J App Pharm 2017;9: 20-30.
12. Peppas NA. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv 1985;60: 110-11.
13. Shweta pawar. Formulation and evaluation of garlic powder loaded floating matrix tablet. Int J Pharm Pharm Sci 2019;11: 17-21.
15 Views | Downloads
How to Cite
REDDY, V. R. “FABRICATION AND EVALUATION OF ORAL CONTROLLED RELEASE OF MUCOADHESIVE ALGINATE MICROBEADS CONTAINING FLUVASTATIN SODIUM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Oct. 2019, https://innovareacademics.in/journals/index.php/ajpcr/article/view/35991.
Original Article(s)