• Vikas P Patil
  • Amarjitsing Premsinh Rajput
  • Pankaj M Chaudhari
  • Swapnil P Chaudhari
  • Dheeraj T Baviskar


Introduction: - Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder that may affect many tissues and organs – skin, blood vessels, heart, lungs and muscles. But principally attacks the joints, producing a non-supportive proliferative sinusitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. Rhumapar tablet is a marketed polyherbal formulation believed to have the potential for providing relief to rheumatoid arthritis (RA) patients.

Objective: - Investigations have been carried out using rats as experimental models, to assess the anti inflammatory and anti arthritic potential of Rhumapar tablet. In-vitro anti-oxidant study has been carried out using different in-vitro models.

Result:- The results obtained demonstrate that Rhumapar tablet can significantly and dose-dependently inhibit carrageenan-induced rat paw oedema (the inhibition at 3 hour was greater than at 1 hour after induction of oedema).Tablet can also significantly inhibit granuloma formation in cotton pellet induced granuloma model. It also showed significant anti-arthritic activity in Freund's complete adjuvant (FCA) induced arthritis. The responses were statistically significant when they were compared with the control.

Conclusion: - It has been indicated that formulation possesses anti- inflammatory and anti-arthritic activities that are probably mediated through inhibition of prostanoid synthesis and free radical scavenging effect.

Keywords: Rhumapar tablet, Rheumatoid arthritis, Anti-inflammatory activity, Anti-arthritic activity, Anti-oxidant activity.


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How to Cite

Patil, V. P., A. P. Rajput, P. M. Chaudhari, S. P. Chaudhari, and D. T. Baviskar. “PHARMACOLOGICAL EVALUATION OF MARKETED POLYHERBAL FORMULATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 8, Sept. 2013, pp. 80-85,