POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY EFFECT OF CUMINUM CYMINUM AND BORAGO OFFICINALIS IN RATS AND MICE
Objective: Our research aimed to study the potential therapeutic effect of Cuminum cyminum and Borago officinalis seed oil against inflammation induced by carrageenan as well as its central and peripheral analgesic effect.
Methods: The anti-inflammatory effect was determined by measuring the edema rate and inhibition rate using Plethysmometer. Writhing test and hot plate test were used to determine the peripheral and central analgesic effect, respectively.
Key Findings: Significant anti-inflammatory effects were witnessed for all the drugs at different dose levels in the results. Substantial analgesic effect against both peripheral and central pain induction was also incurred on administration of all doses of C. cyminum and B. officinalis seed oil.
Conclusion: The C. cyminum and B. officinalis seed oil has potent anti-inflammatory and analgesic effects.
2. Grieve M. A Modern Herbal. New York: Dover Publications; 1971. p. 119.
3. Foolad N, Brezinski EA, Chase EP, Armstrong AW. Effect of nutrient supplementation on atopic dermatitis in children: A systemic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol 2013;149:350-5.
4. Mankowska G, Bylka G. Genetic resources of Cannabis sativa L. At the institute of natural fibers and medicinal plants in Poznan. Herb Pol 2009;55:178-84.
5. Engler M, Engler M. Dietary borage oil alters plasma hepatic and vascular tissue fatty acids composition in spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids 1998;59:11-15.
6. Lee HS. Cuminaldehyde: Aldose reductase and ?-glucosidase inhibitor derived from Cuminum cyminum L. seeds. J Agric Food Chem 2005;53:2446-50.
7. Platel K, Srinivasan K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung 2000;44:42-6.
8. Topal U, Sasaki M, Goto M, Otles S. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. Int J Food Sci Nutr 2008;59:619-34.
9. Wanner J, Bail S, Jirovetz L, Buchbauer G, Schmidt E, Gochev V, et al. Chemical composition and antimicrobial activity of cumin oil (Cuminum cyminum, Apiaceae). Nat Prod Commun 2010;5:1355-8.
10. Juan W, Xitong Z, Bi Y, Miao R, Zhang Z, Su H. Anti-inflammatory effects of cumin essential oil by blocking JNK, ERK, and NF-?B signaling pathways in LPS-stimulated RAW 264.7 cells. Evid Based Complement Alternat Med 2015;2015:474-509.
11. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med 1962;111:544-7.
12. Khalifa NM, Al-Omar MA, Amr Ael-G, Baiuomy AR, Abdel-Rahman RF. SYNTHESIS and biological evaluation of some novel fused thiazolo[3,2a]pyrimidines as potential analgesic and anti-inflammatory agents. Bioorg Khim 2015;41:218-26.
13. Turner RA. Screening Methods in Pharmacology. New York: Academic Press; 1965. p. 158.
14. Olaleye SB, Farombi EO, Adewoye EA, Owoyele BV, Onasanwo SA, Elegbe RA. Analgesic and anti-inflammatory effects of kolaviron (a Garcinia kola seed extract). Afr J Biomed Res 2000;3:171.
15. Subhashis P, Somit D, Tapas KC, Soumen B. Anti-inflammatory and protective properties of aloe vera leaf crude gel in carrageenan induced acute inflammatory rat models. Int J Pharm Pharm Sci 2014;6:368-71.
16. Crunkhorn P, Meacock SC. Mediators of the inflammation induced in the rat paw by carrageenan. Br J Pharmacol 1971;42:392-402.
17. Bensreti MM, Sewell RD. Selective effects of dopaminergic modifiers on antinociception produced by different opioid receptor agonists. Pro Br Pharmacol Soc 1983;28:70.
18. Headley PM, Shaughnessy CT. Evidence for opiate and dopamine interaction in striatum. Br J Pharmacol 1985;86:700.
19. Wigdor S, Wilcox GL. Central and systemic morphine-induced antinociception in mice: Contribution descending serotonergic and noradrenergic pathways. J Pharmacol Exp Ther 1987;242:90.
20. Bentley GA, Newton SH, Starr J. Studies on the antinociceptive action of agonist drugs and their interaction with opioid mechanisms. Br J Pharmacol 1983;79:125.
21. Derardt R, Jongney S, Delevalcee F. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol 1980;51:17.
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