THE ROLE OF ACTIVIN A AND FOLLISTATIN IN THE DIFFERENTIATION BETWEEN VIABLE INTRAUTERINE PREGNANCY FROM MISSED MISCARRIAGE AND ECTOPIC PREGNANCY

  • ESRAA HAMEED HUMADI AL-MAINI Department of Obstetrics and Gynecology, College of Medicine, Al-Mustansiriya University, Al-Yarmouk Teaching Hospital, Baghdad, Iraq. http://orcid.org/0000-0003-1324-5886
  • ISRAA TAILB ABD AL-KADIR Department of Obstetrics and Gynecology, Al-Yarmouk Teaching Hospital, Baghdad, Iraq. http://orcid.org/0000-0001-9242-3147
  • RAWNAQ ALI AL-SAADI Department of Obstetrics and Gynecology, Al-Yarmouk Teaching Hospital, Baghdad, Iraq.

Abstract

Objective: The objective of the study was to investigate the role of activin A and follistatin (FS) in the differentiation between viable intrauterine pregnancy from missed miscarriage and ectopic pregnancy (EP).


Study Design: This was a case–control study.


Setting: This study was conducted at the Department of Obstetrics and Gynecology at Al-Yarmouk Teaching Hospital, from February 2017 to October 2017.


Patients and Methods: The study included 90 pregnant women, aged from 21 to 40 years old in their the first trimester attending the outpatient and inpatient clinic with single fetal pregnancy with a gestational age range between 6th and 8th weeks, they were divided into three groups; Group A: Includes 30 cases with uncomplicated pregnancies in their first trimester, Group B: Includes 30 cases diagnosed as missed miscarriages, and Group C: Includes 30 cases diagnosed as EPs.


Results: There was no significant difference in the maternal age and body mass index between the three groups, β-human chorionic gonadotropin, activin A, FS, and their ratio were significantly higher in the healthy intrauterine pregnancy compared to missed miscarriage and EP. Activin A and activin A/FS ratio had an excellent ability to discriminate EP from healthy intrauterine pregnancy, while FS alone had good ability to discriminate between EP and intrauterine pregnancy. Activin A had fair ability to discriminate missed miscarriage from intra healthy uterine pregnancy, while both FS and activin A/FS ratio had poor ability to differentiate missed miscarriage and intrauterine pregnancy.


Conclusion: Activin A can be used with high accuracy as a biomarker for EP and missed miscarriage, FS alone, and activin A/FS ratio is a possible biomarker, but it offers lower accuracy compared to activin A alone.

Keywords: Activin A, Follistatin, Viable intrauterine pregnancy, Missed miscarriage, Ectopic pregnancy

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ESRAA HAMEED HUMADI AL-MAINI, ISRAA TAILB ABD AL-KADIR, and RAWNAQ ALI AL-SAADI. “THE ROLE OF ACTIVIN A AND FOLLISTATIN IN THE DIFFERENTIATION BETWEEN VIABLE INTRAUTERINE PREGNANCY FROM MISSED MISCARRIAGE AND ECTOPIC PREGNANCY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Nov. 2019, pp. 197-02, doi:10.22159/ajpcr.2019.v12i12.36259.
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