• AHMED ZEROUAL Department of Chemical Products, Laboratory of Material Engineering and Environment, Faculty of Sciences Dhar El Mahraz, B.P. 1796, Fez, Morocco.
  • NOUREDDINE ELOUTASSI Department of Chemical Products, Laboratory of Material Engineering and Environment, Faculty of Sciences Dhar El Mahraz, B.P. 1796, Fez, Morocco.
  • MAHDI CHAOUCH Department of Chemical Products, Laboratory of Material Engineering and Environment, Faculty of Sciences Dhar El Mahraz, B.P. 1796, Fez, Morocco.
  • ABDELLAH CHAQROUNE Department of Chemical Products, Laboratory of Material Engineering and Environment, Faculty of Sciences Dhar El Mahraz, B.P. 1796, Fez, Morocco.


Objective: Origanum compactum is one of the most important medicinal species in terms of ethnobotany in Morocco. It attracts the attention of several research works; however, its chemical composition under local conditions is not well documented. Here, we aimed at determining essential oil chemical composition, antibacterial, and antioxidant activities of organic extracts of O. compactum.

Methods: Antimicrobial activities were assessed against four strains (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicans). Antioxidant activities were estimated by radical 2,2-diphenyl-1-picrylhydrazyl scavenging activity. Polyphenols and flavonoids were determined. Chemical composition was screened using gas chromatography.

Results: Our results showed that yield extracts varied significantly among solvents and ranged from 10.30% (n-hexane) to 31.70% (methanolic). Methanolic extracts had the highest values of yield, polyphenols, and flavonoids, while n-hexane extracts showed the lowest values of yield and polyphenols. Regarding antimicrobial activities, E. coli showed the most important activity. Concerning antioxidant activities, n-hexane extracts had the most important activity. The phytochemical screening revealed 12 compounds. Among them, γ-Terpinene, o-Cymene, and carvacrol were the major compounds (around 73% of total chemical compounds).

Conclusion: It could be concluded that the studied plant might be a promising source of chemical compounds responsible for important biological activities.

Keywords: Origanum compactum, Antioxidant and antimicrobial activities, Chemical composition


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How to Cite
ZEROUAL, A., N. ELOUTASSI, M. CHAOUCH, and A. CHAQROUNE. “ANTIMICROBIAL, ANTIOXIDANT ACTIVITY, AND CHEMICAL COMPOSITION OF ORIGANUM COMPACTUM BENTH FROM TAOUNATE PROVINCE, NORTH MOROCCO”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 3, Jan. 2020, pp. 126-31, doi:10.22159/ajpcr.2020.v13i3.36319.
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