PHYTOCHEMISTRY SCREENING AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN KARO TRADITIONAL OIL, AN INDONESIAN TRADITIONAL HERBAL MEDICINE

  • NOVA PRIMADINA Department of Airlangga University, Surabaya, Indonesia.
  • ACHMAD BASORI Department of Pharmacology, Airlangga University, Surabaya, Indonesia.
  • DAVID S PERDANAKUSUMA Department of Plastic Surgery, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia.

Abstract

Objective: The purpose of this research was to observe the bioactive compounds of Karo traditional oil by phytochemistry screening and gas chromatography-mass spectrometry (GC-MS) analysis. Alkaloid,


Results: Terpenoid and flavonoid compounds were found, and no polyphenol compound from phytochemistry screening and 16 constituents were identified from the GC-MS analysis, α-pinene was found as the major component (74.47%), delta-3-carene (9.62%), 1% of octane, dodecane, camphor, undecane, isodecane, sabinene, hexadecane, nonane, and <1% tridecane, cyclohexane, pentacosane, heptadecan, limonene, and camphene.


Conclusion: Karo traditional oil works as a potent anti-inflammation at the inflammation phase of the wound healing process by suppressing the pro-inflammatory cytokines and promote anti-inflammatory cytokines.

Keywords: Traditional medicine, Indonesia traditional medicine, Phytochemistry screening, Gas chromatography-mass spectrometry, Karo oil, Karo traditional oil, Wound healing

Author Biography

DAVID S PERDANAKUSUMA, Department of Plastic Surgery, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia.
  • Lecturer of Plastic Surgery Department of Airlangga University - dr.Soetomo Hospital Surabaya – Indonesia
  • Vice dean of Medical Faculty, Airlangga University

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PRIMADINA, N., A. BASORI, and D. S PERDANAKUSUMA. “PHYTOCHEMISTRY SCREENING AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN KARO TRADITIONAL OIL, AN INDONESIAN TRADITIONAL HERBAL MEDICINE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 2, Jan. 2020, pp. 204-8, doi:10.22159/ajpcr.2020.v13i2.36736.
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