EVALUATION OF IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF AEGLE MARMELOS LEAF EXTRACTS

  • MUJAWAR SALMA BEGUM HUSSAIN Department of Biotechnology and Microbiology, Pavate Nagar, Karnatak University, Dharwad, Karnataka, India.
  • MURIGENDRA BASAYYA HIREMATH Department of Biotechnology and Microbiology, Pavate Nagar, Karnatak University, Dharwad, Karnataka, India.

Abstract

Objective: The present study aims to investigate preliminary phytochemicals to determine the total phenolic and flavonoid contents and to undergo in vitro antioxidant and anti-inflammatory activities of leaf extracts of Aegle marmelos.


Methods: Estimation of total phenols and flavonoids and in vitro antioxidant and anti-inflammatory activities of leaf extracts of A. marmelos was carried out using standard protocols.


Results: The highest amount of phenolic and flavonoid content was present in aqueous extract (92.08±0.91 mg/g gallic acid equivalent) and (52.73±0.51 mg/g QE), it also proved to have the most potent antioxidant activity at a concentration of 10 μg/ml (45.57±0.27%) with IC50 values 190 μg/ml. Ethanol extract exhibited the highest anti-inflammatory activity (88.16±0.25) at 100 μg/ml with IC50 values 34.59 μg/ml.


Conclusion: It can be concluded that the tested extracts hold significant antioxidant and anti-inflammatory activities. However, further investigation of purified compounds of A. marmelos will enable its medicinal use in the treatment of various disorders.

Keywords: Aegle marmelos, Phytochemicals, Antioxidant, Anti-inflammatory

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BEGUM HUSSAIN, M. S., and M. BASAYYA HIREMATH. “EVALUATION OF IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF AEGLE MARMELOS LEAF EXTRACTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 2, Jan. 2020, pp. 209-13, doi:10.22159/ajpcr.2020.v13i2.36870.
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