KETOPROFEN-CARBOXYMETHYL CHITOSAN MICROPARTICLES PREPARED BY IONIC CROSSLINKING - SPRAY DRYING : OPTIMIZATION AND EVALUATION
Objective: The aim of this research was to investigate the effect of two operating parameters (inlet temperature and pump speed) of laboratory
spray dryer to optimize the production of ketoprofen-carboxymethyl chitosan (CM chitosan) microparticles and the effect of carboxymethyl chitosan
concentration on microparticles characteristics.
Methods: Microparticles with various concentration of CM chitosan were prepared by ionic gelation with CaCl2, then dried by spray drying with
various inlet temperature and pump speed. The obtained microparticles were evaluation for particle size, drug entrapment efficiency and drug
Results: The results showed that inlet temperature at 100Â°C and pump speed at 9.0 ml/min was known to be the optimum condition since the drying
process was relatively faster and it could produce the most yield. The obtained CM chitosan microparticles have irregular and hollow shape with the
size of 1.1 â€“ 2.1 Î¼m. As carboxymethyl chitosan concentration increased, mean particle size and drug entrapment efficiency of the drugs increased.
In simulated intestinal fluid media pH 6.8, the release rate of ketoprofen from microparticles was delayed up to 0.43 times slower than ketoprofen
Conclusion: The optimal condition for spray drying in this study was at pump speed 9.0 ml/min with inlet temperature 100Â°C, since it gave the
most yield compare to other conditions. The size of ketoprofen-CM chitosan microparticles were between the range of 1.1 â€“ 2.1 Î¼m with high drug
entrapment. In general, microparticles of CM chitosan could delay ketoprofen release in simulated intestinal fluid media.
Keywords: Microparticles, Spray drying, Ketoprofen, Carboxymethyl chitosan.
2. Jayakumar R, Prabaharan M, Nair SV, Tokura S, Tamura H, Selvamurugan N. Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog Mater Sci 2010;55(7):675-709.
3. Mourya VK, Inamdar NN, Ashutosh T. Carboxymethyl chitosan and its applications. Adv Mater Lett 2010;1(1):11-33.
4. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release 2004;100(1):5-28.
5. Patil P, Daksha C, Milind W. A review on ionotropic gelation method: novel approach for controlled gastroretentive gelispheres. Int J Pharm Pharm Sci 2012;4(4):27-32.
6. Amaro MI, Tajber L, Corrigan OI, Healy AM. Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation. Int J Pharm 2011;421:99-109.
7. He P, Davis SS, Illum L. Chitosan microspheres prepared by spray drying. Int J Pharm 1999;187:53-65.
8. Del Gaudio P, Russo P, Rosaria Lauro M, Colombo P, Aquino RP. Encapsulation of ketoprofen and ketoprofen lysinate by prilling for controlled drug release. AAPS PharmSciTech 2009;10(4):1178-85.
9. Sweetman SC. Martindale the Complete Drug Reference. (36th ed). London: Pharmaceutical Press; 2009. p. 73-4.
10. Patel AS, Soni TG, Thakkar VT, Gandhi. TR. Effect of polymeric blend on the dissolution behavior of spray-dried microparticles. Int J Res Pharm Chem 2011;1(3):690-701.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.